A new phthalide derivative from Peperomia nivalis

Pedro Vásquez-Ocmín; Mohamed Haddad; Alice Gadea; Valérie Jullian; Denis Castillo; Lucie Paloque; Juan Pablo Cerapio; Geneviève Bourdy; Michel Sauvain

doi:10.1080/14786419.2016.1219857

A new phthalide derivative from Peperomia nivalis

Pedro Vásquez-Ocmín
, Mohamed Haddad
, Alice Gadea
, Valérie Jullian
, Denis Castillo
, Lucie Paloque
, Juan Pablo Cerapio
, Geneviève Bourdy
, Michel Sauvain

School of Science and Engineering

Universidad Peruana Cayetano Heredia
Université de Toulouse
LCC (Laboratoire de Chimie de Coordination) UPR8241
Université de Toulouse

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

One new phthalide (1) was isolated from aerial parts of Peperomia nivalis, along with known compounds (2 and 3), reported in this species for the first time. The structure of the new compound was characterised on the basis of 1D (¹H and¹³C NMR), 2D (COSY, HMQC, HMBC and NOESY) NMR and high-resolution mass spectral (HRMS) data. Compound 2 was isolated from a natural source for the first time but previously synthesised. Compounds 1–3 were evaluated for their anti-Helicobacter pylori and anti-Plasmodium falciparum activities. Compound 1 showed moderate activities against H. pylori (MIC 47.5 μM) and the F32-Tanzania strain of P. falciparum (IC₅₀8.5 μM). Compounds 2 and 3 exhibited weak anti-H. pylori activity (MIC 241.3 and 237.6 μM, respectively) and were inactive against P. falciparum.

Original language	English
Pages (from-to)	138-142
Number of pages	5
Journal	Natural Product Research
Volume	31
Issue number	2
DOIs	https://doi.org/10.1080/14786419.2016.1219857
State	Published - 2017

Keywords

Helicobacter pylori
NMR
Peperomia nivalis
Plasmodium
phthalide
secondary metabolites

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10.1080/14786419.2016.1219857

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title = "A new phthalide derivative from Peperomia nivalis",

abstract = "One new phthalide (1) was isolated from aerial parts of Peperomia nivalis, along with known compounds (2 and 3), reported in this species for the first time. The structure of the new compound was characterised on the basis of 1D (1H and13C NMR), 2D (COSY, HMQC, HMBC and NOESY) NMR and high-resolution mass spectral (HRMS) data. Compound 2 was isolated from a natural source for the first time but previously synthesised. Compounds 1–3 were evaluated for their anti-Helicobacter pylori and anti-Plasmodium falciparum activities. Compound 1 showed moderate activities against H. pylori (MIC 47.5 μM) and the F32-Tanzania strain of P. falciparum (IC508.5 μM). Compounds 2 and 3 exhibited weak anti-H. pylori activity (MIC 241.3 and 237.6 μM, respectively) and were inactive against P. falciparum.",

keywords = "Helicobacter pylori, NMR, Peperomia nivalis, Plasmodium, phthalide, secondary metabolites",

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T1 - A new phthalide derivative from Peperomia nivalis

AU - Vásquez-Ocmín, Pedro

AU - Haddad, Mohamed

AU - Gadea, Alice

AU - Jullian, Valérie

AU - Castillo, Denis

AU - Paloque, Lucie

AU - Cerapio, Juan Pablo

AU - Bourdy, Geneviève

AU - Sauvain, Michel

PY - 2017

Y1 - 2017

N2 - One new phthalide (1) was isolated from aerial parts of Peperomia nivalis, along with known compounds (2 and 3), reported in this species for the first time. The structure of the new compound was characterised on the basis of 1D (1H and13C NMR), 2D (COSY, HMQC, HMBC and NOESY) NMR and high-resolution mass spectral (HRMS) data. Compound 2 was isolated from a natural source for the first time but previously synthesised. Compounds 1–3 were evaluated for their anti-Helicobacter pylori and anti-Plasmodium falciparum activities. Compound 1 showed moderate activities against H. pylori (MIC 47.5 μM) and the F32-Tanzania strain of P. falciparum (IC508.5 μM). Compounds 2 and 3 exhibited weak anti-H. pylori activity (MIC 241.3 and 237.6 μM, respectively) and were inactive against P. falciparum.

AB - One new phthalide (1) was isolated from aerial parts of Peperomia nivalis, along with known compounds (2 and 3), reported in this species for the first time. The structure of the new compound was characterised on the basis of 1D (1H and13C NMR), 2D (COSY, HMQC, HMBC and NOESY) NMR and high-resolution mass spectral (HRMS) data. Compound 2 was isolated from a natural source for the first time but previously synthesised. Compounds 1–3 were evaluated for their anti-Helicobacter pylori and anti-Plasmodium falciparum activities. Compound 1 showed moderate activities against H. pylori (MIC 47.5 μM) and the F32-Tanzania strain of P. falciparum (IC508.5 μM). Compounds 2 and 3 exhibited weak anti-H. pylori activity (MIC 241.3 and 237.6 μM, respectively) and were inactive against P. falciparum.

KW - Helicobacter pylori

KW - NMR

KW - Peperomia nivalis

KW - Plasmodium

KW - phthalide

KW - secondary metabolites

UR - https://www.scopus.com/pages/publications/84983541200

U2 - 10.1080/14786419.2016.1219857

DO - 10.1080/14786419.2016.1219857

M3 - Artículo

C2 - 27561759

AN - SCOPUS:84983541200

SN - 1478-6419

VL - 31

SP - 138

EP - 142

JO - Natural Product Research

JF - Natural Product Research

IS - 2

ER -

A new phthalide derivative from Peperomia nivalis

Abstract

Keywords

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