A novel antiprotozoal aminosteroid from Saracha punctata

C. Moretti; M. Sauvain; C. Lavaud; G. Massiot; J. A. Bravo; V. Muñoz

doi:10.1021/np9800654

A novel antiprotozoal aminosteroid from Saracha punctata

C. Moretti
, M. Sauvain
, C. Lavaud
, G. Massiot
, J. A. Bravo
, V. Muñoz

Unité de Recherche No. 45
Université de Reims Champagne-Ardenne
Universidad Nacional Mayor de San Andrés
Inst. Boliviano de Biol. de Altura

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC₅₀ of 25 nM.

Original language	English
Pages (from-to)	1390-1393
Number of pages	4
Journal	Journal of Natural Products
Volume	61
Issue number	11
DOIs	https://doi.org/10.1021/np9800654
State	Published - Nov 1998
Externally published	Yes

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title = "A novel antiprotozoal aminosteroid from Saracha punctata",

abstract = "A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100\% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50\% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.",

author = "C. Moretti and M. Sauvain and C. Lavaud and G. Massiot and Bravo, \{J. A.\} and V. Mu{\~n}oz",

year = "1998",

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doi = "10.1021/np9800654",

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volume = "61",

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T1 - A novel antiprotozoal aminosteroid from Saracha punctata

AU - Moretti, C.

AU - Sauvain, M.

AU - Lavaud, C.

AU - Massiot, G.

AU - Bravo, J. A.

AU - Muñoz, V.

PY - 1998/11

Y1 - 1998/11

N2 - A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.

AB - A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.

UR - https://www.scopus.com/pages/publications/0031791054

U2 - 10.1021/np9800654

DO - 10.1021/np9800654

M3 - Artículo

C2 - 9834160

AN - SCOPUS:0031791054

SN - 0163-3864

VL - 61

SP - 1390

EP - 1393

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

A novel antiprotozoal aminosteroid from Saracha punctata

Abstract

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