A scoping review of cost-effectiveness of screening and treatment for latent tuberculosis infection in migrants from high-incidence countries

COHEMI Project Study Group

doi:10.1186/s12913-015-1045-3

A scoping review of cost-effectiveness of screening and treatment for latent tuberculosis infection in migrants from high-incidence countries

COHEMI Project Study Group

University of Florence
Istituto di Ricerche Farmacologiche Mario Negri
Azienda Ospedaliero-Universitaria Careggi
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt
University of Brescia
SacroCuore-Don Calabria Hospital
Ivo de Carneri Foundation
Universitat de Barcelona
University of Amsterdam
Hospital for Tropical Diseases
Centre for Community Epidemiology and Tropical Medicine
Universidad Peruana Cayetano Heredia
Colectivo de EstudiosAplicados y Desarrollo Social
Taller de Educacion y Comunicacion TEKO-GUARANÌ
University of Catania

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Background: In low-incidence countries, most tuberculosis (TB) cases occur among migrants and are caused by reactivation of latent tuberculosis infection (LTBI) acquired in the country of origin. Diagnosis and treatment of LTBI are rarely implemented to reduce the burden of TB in immigrants, partly because the cost-effectiveness profile of this intervention is uncertain. The objective of this research is to perform a review of the literature to assess the cost-effectiveness of LTBI diagnosis and treatment strategies in migrants. Methods: Scoping review of economic evaluations on LTBI screening strategies for migrants was carried out in Medline. Results: Nine studies met the inclusion criteria. LTBI screening was cost-effective according to seven studies. Findings of four studies support interferon gamma release assay as the most cost-effective test for LTBI screening in migrants. Two studies found that LTBI screening is cost-effective only if carried out in immigrants who are contacts of active TB cases. Discussion and Conclusions: Our findings support the cost-effectiveness of LTBI diagnostic and treatment strategies in migrants especially if they are focused on young subjects from high incidence countries. These strategies could represent and adjunctive and synergistic tool to achieve the ambitious aim of TB elimination.

Original language	English
Article number	412
Journal	BMC Health Services Research
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s12913-015-1045-3
State	Published - 24 Sep 2015

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SDG 3 Good Health and Well-being

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10.1186/s12913-015-1045-3

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title = "A scoping review of cost-effectiveness of screening and treatment for latent tuberculosis infection in migrants from high-incidence countries",

abstract = "Background: In low-incidence countries, most tuberculosis (TB) cases occur among migrants and are caused by reactivation of latent tuberculosis infection (LTBI) acquired in the country of origin. Diagnosis and treatment of LTBI are rarely implemented to reduce the burden of TB in immigrants, partly because the cost-effectiveness profile of this intervention is uncertain. The objective of this research is to perform a review of the literature to assess the cost-effectiveness of LTBI diagnosis and treatment strategies in migrants. Methods: Scoping review of economic evaluations on LTBI screening strategies for migrants was carried out in Medline. Results: Nine studies met the inclusion criteria. LTBI screening was cost-effective according to seven studies. Findings of four studies support interferon gamma release assay as the most cost-effective test for LTBI screening in migrants. Two studies found that LTBI screening is cost-effective only if carried out in immigrants who are contacts of active TB cases. Discussion and Conclusions: Our findings support the cost-effectiveness of LTBI diagnostic and treatment strategies in migrants especially if they are focused on young subjects from high incidence countries. These strategies could represent and adjunctive and synergistic tool to achieve the ambitious aim of TB elimination.",

author = "\{COHEMI Project Study Group\} and Lorenzo Zammarchi and Gianluigi Casadei and Marianne Strohmeyer and Filippo Bartalesi and Carola Liendo and Alberto Matteelli and Maurizio Bonati and Eduardo Gotuzzo and Alessandro Bartoloni and Chiara Pandolfini and Francesca Severino and Valeria Confalonieri and Gianni Tognoni and Zeno Bisoffi and Dora Buonfrate and Andrea Angheben and Marco Albonico and Jose Mu{\~n}oz and Ana Requena-Mendez and Maria Roura and Laia Ventura and Robert Pool and Christopher Pell and Anita Hardon and Peter Chiodini and Juan Moreira and Mariella Anselmi and Roberto Semp{\'e}rtegui and Mena, \{Maria Alejandra\} and Garcia, \{H{\'e}ctor H.\} and Javier Bustos and Saul Santiva{\~n}ez and Faustino Torrico and Daniel Lozano and Cabrera, \{Teresa Hinojosa\} and Mor{\'o}n, \{Javier Ochoa\} and Ignacio AbaporiCuellar and Suarez, \{Jaime Amor{\'o}s\} and Guido ChumirayRojas and Alessandra Nicoletti and Elisa Bruno",

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TY - JOUR

T1 - A scoping review of cost-effectiveness of screening and treatment for latent tuberculosis infection in migrants from high-incidence countries

AU - COHEMI Project Study Group

AU - Zammarchi, Lorenzo

AU - Casadei, Gianluigi

AU - Strohmeyer, Marianne

AU - Bartalesi, Filippo

AU - Liendo, Carola

AU - Matteelli, Alberto

AU - Bonati, Maurizio

AU - Gotuzzo, Eduardo

AU - Bartoloni, Alessandro

AU - Pandolfini, Chiara

AU - Severino, Francesca

AU - Confalonieri, Valeria

AU - Tognoni, Gianni

AU - Bisoffi, Zeno

AU - Buonfrate, Dora

AU - Angheben, Andrea

AU - Albonico, Marco

AU - Muñoz, Jose

AU - Requena-Mendez, Ana

AU - Roura, Maria

AU - Ventura, Laia

AU - Pool, Robert

AU - Pell, Christopher

AU - Hardon, Anita

AU - Chiodini, Peter

AU - Moreira, Juan

AU - Anselmi, Mariella

AU - Sempértegui, Roberto

AU - Mena, Maria Alejandra

AU - Garcia, Héctor H.

AU - Bustos, Javier

AU - Santivañez, Saul

AU - Torrico, Faustino

AU - Lozano, Daniel

AU - Cabrera, Teresa Hinojosa

AU - Morón, Javier Ochoa

AU - AbaporiCuellar, Ignacio

AU - Suarez, Jaime Amorós

AU - ChumirayRojas, Guido

AU - Nicoletti, Alessandra

AU - Bruno, Elisa

PY - 2015/9/24

Y1 - 2015/9/24

N2 - Background: In low-incidence countries, most tuberculosis (TB) cases occur among migrants and are caused by reactivation of latent tuberculosis infection (LTBI) acquired in the country of origin. Diagnosis and treatment of LTBI are rarely implemented to reduce the burden of TB in immigrants, partly because the cost-effectiveness profile of this intervention is uncertain. The objective of this research is to perform a review of the literature to assess the cost-effectiveness of LTBI diagnosis and treatment strategies in migrants. Methods: Scoping review of economic evaluations on LTBI screening strategies for migrants was carried out in Medline. Results: Nine studies met the inclusion criteria. LTBI screening was cost-effective according to seven studies. Findings of four studies support interferon gamma release assay as the most cost-effective test for LTBI screening in migrants. Two studies found that LTBI screening is cost-effective only if carried out in immigrants who are contacts of active TB cases. Discussion and Conclusions: Our findings support the cost-effectiveness of LTBI diagnostic and treatment strategies in migrants especially if they are focused on young subjects from high incidence countries. These strategies could represent and adjunctive and synergistic tool to achieve the ambitious aim of TB elimination.

AB - Background: In low-incidence countries, most tuberculosis (TB) cases occur among migrants and are caused by reactivation of latent tuberculosis infection (LTBI) acquired in the country of origin. Diagnosis and treatment of LTBI are rarely implemented to reduce the burden of TB in immigrants, partly because the cost-effectiveness profile of this intervention is uncertain. The objective of this research is to perform a review of the literature to assess the cost-effectiveness of LTBI diagnosis and treatment strategies in migrants. Methods: Scoping review of economic evaluations on LTBI screening strategies for migrants was carried out in Medline. Results: Nine studies met the inclusion criteria. LTBI screening was cost-effective according to seven studies. Findings of four studies support interferon gamma release assay as the most cost-effective test for LTBI screening in migrants. Two studies found that LTBI screening is cost-effective only if carried out in immigrants who are contacts of active TB cases. Discussion and Conclusions: Our findings support the cost-effectiveness of LTBI diagnostic and treatment strategies in migrants especially if they are focused on young subjects from high incidence countries. These strategies could represent and adjunctive and synergistic tool to achieve the ambitious aim of TB elimination.

UR - https://www.scopus.com/pages/publications/84942156014

U2 - 10.1186/s12913-015-1045-3

DO - 10.1186/s12913-015-1045-3

M3 - Artículo de revisión

C2 - 26399233

AN - SCOPUS:84942156014

SN - 1472-6963

VL - 15

JO - BMC Health Services Research

JF - BMC Health Services Research

IS - 1

M1 - 412

ER -

A scoping review of cost-effectiveness of screening and treatment for latent tuberculosis infection in migrants from high-incidence countries

Abstract

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