Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera

Rosario Rojas; Luz Caviedes; José C. Aponte; Abraham J. Vaisberg; Walter H. Lewis; Gerardo Lamas; César Sarasara; Robert H. Gilman; Gerald B. Hammond

doi:10.1021/np050554l

Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera

Rosario Rojas
, Luz Caviedes
, José C. Aponte
, Abraham J. Vaisberg
, Walter H. Lewis
, Gerardo Lamas
, César Sarasara
, Robert H. Gilman
, Gerald B. Hammond

School of Science and Engineering

Universidad Peruana Cayetano Heredia
University of Louisville
Washington University in St. Louis
Museo de Historia Natural, Lima
Confederacion de Nacionalidades Amazónicas Del Perú
Johns Hopkins Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).

Original language	English
Pages (from-to)	845-846
Number of pages	2
Journal	Journal of Natural Products
Volume	69
Issue number	5
DOIs	https://doi.org/10.1021/np050554l
State	Published - May 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1021/np050554l

Cite this

@article{01effa37660a4d8c81e579fee202f49f,

title = "Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera",

abstract = "An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).",

author = "Rosario Rojas and Luz Caviedes and Aponte, \{Jos{\'e} C.\} and Vaisberg, \{Abraham J.\} and Lewis, \{Walter H.\} and Gerardo Lamas and C{\'e}sar Sarasara and Gilman, \{Robert H.\} and Hammond, \{Gerald B.\}",

year = "2006",

month = may,

doi = "10.1021/np050554l",

language = "Ingl{\'e}s",

volume = "69",

pages = "845--846",

journal = "Journal of Natural Products",

issn = "0163-3864",

number = "5",

}

TY - JOUR

T1 - Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera

AU - Rojas, Rosario

AU - Caviedes, Luz

AU - Aponte, José C.

AU - Vaisberg, Abraham J.

AU - Lewis, Walter H.

AU - Lamas, Gerardo

AU - Sarasara, César

AU - Gilman, Robert H.

AU - Hammond, Gerald B.

PY - 2006/5

Y1 - 2006/5

N2 - An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).

AB - An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).

UR - https://www.scopus.com/pages/publications/33745785031

U2 - 10.1021/np050554l

DO - 10.1021/np050554l

M3 - Artículo

C2 - 16724857

AN - SCOPUS:33745785031

SN - 0163-3864

VL - 69

SP - 845

EP - 846

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this