TY - JOUR
T1 - Age of onset and lifetime projected risk of psychotic experiences
T2 - Cross-national data from the world mental health survey
AU - McGrath, John J.
AU - Saha, Sukanta
AU - Al-Hamzawi, Ali O.
AU - Alonso, Jordi
AU - Andrade, Laura
AU - Borges, Guilherme
AU - Bromet, Evelyn J.
AU - Browne, Mark Oakley
AU - Bruffaerts, Ronny
AU - Caldas De Almeida, Jose M.
AU - Fayyad, John
AU - Florescu, Silvia
AU - De Girolamo, Giovanni
AU - Gureje, Oye
AU - Hu, Chiyi
AU - De Jonge, Peter
AU - Kovess-Masfety, Viviane
AU - Lepine, Jean Pierre
AU - Lim, Carmen C.W.
AU - Navarro-Mateu, Fernando
AU - Piazza, Maria
AU - Sampson, Nancy
AU - Posada-Villa, José
AU - Kendler, Kenneth S.
AU - Kessler, Ronald C.
N1 - Publisher Copyright:
© The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
PY - 2016/7
Y1 - 2016/7
N2 - Background: Given the early age of onset (AOO) of psychotic disorders, it has been assumed that psychotic experiences (PEs) would have a similar early AOO. The aims of this study were to describe (a) the AOO distribution of PEs, (b) the projected lifetime risk of PEs, and (c) the associations of PE AOO with selected PE features. Methods: Data came from the WHO World Mental Health (WMH) surveys. A total of 31 261 adult respondents across 18 countries were assessed for lifetime prevalence of PE. Projected lifetime risk (at age 75 years) was estimated using a 2-part actuarial method. AOO distributions were described for the observed and projected estimates. We examined associations of AOO with PE type metric and annualized PE frequency. Results: Projected lifetime risk for PEs was 7.8% (SE = 0.3), slightly higher than lifetime prevalence (5.8%, SE = 0.2). The median (interquartile range; IQR) AOO based on projected lifetime estimates was 26 (17-41) years, indicating that PEs commence across a wide age range. The AOO distributions for PEs did not differ by sex. Early AOO was positively associated with number of PE types (F = 14.1, P < .001) but negatively associated with annualized PE frequency rates (F = 8.0, P < .001). Discussion: While most people with lifetime PEs have first onsets in adolescence or young adulthood, projected estimates indicate that nearly a quarter of first onsets occur after age 40 years. The extent to which late onset PEs are associated with (a) late onset mental disorders or (b) declining cognitive and/or sensory function need further research.
AB - Background: Given the early age of onset (AOO) of psychotic disorders, it has been assumed that psychotic experiences (PEs) would have a similar early AOO. The aims of this study were to describe (a) the AOO distribution of PEs, (b) the projected lifetime risk of PEs, and (c) the associations of PE AOO with selected PE features. Methods: Data came from the WHO World Mental Health (WMH) surveys. A total of 31 261 adult respondents across 18 countries were assessed for lifetime prevalence of PE. Projected lifetime risk (at age 75 years) was estimated using a 2-part actuarial method. AOO distributions were described for the observed and projected estimates. We examined associations of AOO with PE type metric and annualized PE frequency. Results: Projected lifetime risk for PEs was 7.8% (SE = 0.3), slightly higher than lifetime prevalence (5.8%, SE = 0.2). The median (interquartile range; IQR) AOO based on projected lifetime estimates was 26 (17-41) years, indicating that PEs commence across a wide age range. The AOO distributions for PEs did not differ by sex. Early AOO was positively associated with number of PE types (F = 14.1, P < .001) but negatively associated with annualized PE frequency rates (F = 8.0, P < .001). Discussion: While most people with lifetime PEs have first onsets in adolescence or young adulthood, projected estimates indicate that nearly a quarter of first onsets occur after age 40 years. The extent to which late onset PEs are associated with (a) late onset mental disorders or (b) declining cognitive and/or sensory function need further research.
KW - Age of onset
KW - Epidemiology
KW - Lifetime prevalence
KW - Psychotic experiences
KW - World Mental Health Survey
UR - https://www.scopus.com/pages/publications/84979279868
U2 - 10.1093/schbul/sbw011
DO - 10.1093/schbul/sbw011
M3 - Artículo
C2 - 27038468
AN - SCOPUS:84979279868
SN - 0586-7614
VL - 42
SP - 933
EP - 941
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 4
ER -