Anti-infective and cytotoxic compounds present in Blepharodon nitidum

José C. Aponte; Yannick Estevez; Robert H. Gilman; Walter H. Lewis; Rosario Rojas; Michel Sauvain; Abraham J. Vaisberg; Gerald B. Hammond

doi:10.1055/s-2008-1034330

Anti-infective and cytotoxic compounds present in Blepharodon nitidum

José C. Aponte
, Yannick Estevez
, Robert H. Gilman
, Walter H. Lewis
, Rosario Rojas
, Michel Sauvain
, Abraham J. Vaisberg
, Gerald B. Hammond

School of Science and Engineering

University of Louisville
Université de Toulouse
Johns Hopkins Bloomberg School of Public Health
Universidad Peruana Cayetano Heredia
Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

Original language	English
Pages (from-to)	407-410
Number of pages	4
Journal	Planta medica
Volume	74
Issue number	4
DOIs	https://doi.org/10.1055/s-2008-1034330
State	Published - Mar 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-infective
Antileishmania
Asclepiadaceae
Blepharodon nitidum
Cytotoxic
Hydroperoxycycloartanes

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10.1055/s-2008-1034330

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title = "Anti-infective and cytotoxic compounds present in Blepharodon nitidum",

abstract = "A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.",

keywords = "Anti-infective, Antileishmania, Asclepiadaceae, Blepharodon nitidum, Cytotoxic, Hydroperoxycycloartanes",

author = "Aponte, \{Jos{\'e} C.\} and Yannick Estevez and Gilman, \{Robert H.\} and Lewis, \{Walter H.\} and Rosario Rojas and Michel Sauvain and Vaisberg, \{Abraham J.\} and Hammond, \{Gerald B.\}",

year = "2008",

month = mar,

doi = "10.1055/s-2008-1034330",

language = "Ingl{\'e}s",

volume = "74",

pages = "407--410",

journal = "Planta medica",

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TY - JOUR

T1 - Anti-infective and cytotoxic compounds present in Blepharodon nitidum

AU - Aponte, José C.

AU - Estevez, Yannick

AU - Gilman, Robert H.

AU - Lewis, Walter H.

AU - Rojas, Rosario

AU - Sauvain, Michel

AU - Vaisberg, Abraham J.

AU - Hammond, Gerald B.

PY - 2008/3

Y1 - 2008/3

N2 - A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

AB - A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

KW - Anti-infective

KW - Antileishmania

KW - Asclepiadaceae

KW - Blepharodon nitidum

KW - Cytotoxic

KW - Hydroperoxycycloartanes

UR - https://www.scopus.com/pages/publications/42549130281

U2 - 10.1055/s-2008-1034330

DO - 10.1055/s-2008-1034330

M3 - Artículo

C2 - 18484532

AN - SCOPUS:42549130281

SN - 0032-0943

VL - 74

SP - 407

EP - 410

JO - Planta medica

JF - Planta medica

IS - 4

ER -

Anti-infective and cytotoxic compounds present in Blepharodon nitidum

Abstract

UN SDGs

Keywords

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