Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission

Alexandra Schwarz; Jenny Ancca Juarez; Jean Richards; Bruno Rath; Victor Quispe Machaca; Yagahira E. Castro; Edith S. Málaga; Katelyn Levy; Robert H. Gilman; Caryn Bern; Manuela Verastegui; Michael Z. Levy

doi:10.1016/j.ijpara.2011.02.001

Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission

Alexandra Schwarz
, Jenny Ancca Juarez
, Jean Richards
, Bruno Rath
, Victor Quispe Machaca
, Yagahira E. Castro
, Edith S. Málaga
, Katelyn Levy
, Robert H. Gilman
, Caryn Bern
, Manuela Verastegui
, Michael Z. Levy

Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic
Universidad Peruana Cayetano Heredia
Asociación Benéfica PRISMA
Perelman School of Medicine at University of Pennsylvania
Johns Hopkins Bloomberg School of Public Health
Centers for Disease Control and Prevention

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequeña, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease.

Original language	English
Pages (from-to)	591-594
Number of pages	4
Journal	International Journal for Parasitology
Volume	41
Issue number	6
DOIs	https://doi.org/10.1016/j.ijpara.2011.02.001
State	Published - May 2011
Externally published	Yes

Keywords

Antibody response
Impregnated net
Saliva
Sentinel guinea pig
Triatoma infestans

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10.1016/j.ijpara.2011.02.001

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Schwarz, A., Juarez, J. A., Richards, J., Rath, B., Machaca, V. Q., Castro, Y. E., Málaga, E. S., Levy, K., Gilman, R. H., Bern, C., Verastegui, M., & Levy, M. Z. (2011). Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission. International Journal for Parasitology, 41(6), 591-594. https://doi.org/10.1016/j.ijpara.2011.02.001

@article{d8348d1830d04320ac96517d26d9ba39,

title = "Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission",

abstract = "Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Queque{\~n}a, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease.",

keywords = "Antibody response, Impregnated net, Saliva, Sentinel guinea pig, Triatoma infestans",

author = "Alexandra Schwarz and Juarez, \{Jenny Ancca\} and Jean Richards and Bruno Rath and Machaca, \{Victor Quispe\} and Castro, \{Yagahira E.\} and M{\'a}laga, \{Edith S.\} and Katelyn Levy and Gilman, \{Robert H.\} and Caryn Bern and Manuela Verastegui and Levy, \{Michael Z.\}",

year = "2011",

month = may,

doi = "10.1016/j.ijpara.2011.02.001",

language = "Ingl{\'e}s",

volume = "41",

pages = "591--594",

journal = "International Journal for Parasitology",

issn = "0020-7519",

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Schwarz, A, Juarez, JA, Richards, J, Rath, B, Machaca, VQ, Castro, YE, Málaga, ES, Levy, K, Gilman, RH, Bern, C, Verastegui, M & Levy, MZ 2011, 'Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission', International Journal for Parasitology, vol. 41, no. 6, pp. 591-594. https://doi.org/10.1016/j.ijpara.2011.02.001

TY - JOUR

T1 - Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission

AU - Schwarz, Alexandra

AU - Juarez, Jenny Ancca

AU - Richards, Jean

AU - Rath, Bruno

AU - Machaca, Victor Quispe

AU - Castro, Yagahira E.

AU - Málaga, Edith S.

AU - Levy, Katelyn

AU - Gilman, Robert H.

AU - Bern, Caryn

AU - Verastegui, Manuela

AU - Levy, Michael Z.

PY - 2011/5

Y1 - 2011/5

N2 - Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequeña, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease.

AB - Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequeña, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease.

KW - Antibody response

KW - Impregnated net

KW - Saliva

KW - Sentinel guinea pig

KW - Triatoma infestans

UR - https://www.scopus.com/pages/publications/79954850719

U2 - 10.1016/j.ijpara.2011.02.001

DO - 10.1016/j.ijpara.2011.02.001

M3 - Artículo

C2 - 21426907

AN - SCOPUS:79954850719

SN - 0020-7519

VL - 41

SP - 591

EP - 594

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 6

ER -

Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission

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Keywords

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