Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum

V. Muñoz; Michel Sauvain; P. Mollinedo; J. Callapa; I. Rojas; A. Gimenez; A. Valentin; M. Mallié

doi:10.1055/s-2006-960808

Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum

V. Muñoz
, Michel Sauvain
, P. Mollinedo
, J. Callapa
, I. Rojas
, A. Gimenez
, A. Valentin
, M. Mallié

Inst. Boliviano de Biol. de Altura
Institut de recherche pour le développement (IRD)
Universidad Nacional Mayor de San Andrés
Université de Montpellier

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

(-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).

Original language	English
Pages (from-to)	448-449
Number of pages	2
Journal	Planta medica
Volume	65
Issue number	5
DOIs	https://doi.org/10.1055/s-2006-960808
State	Published - 1999
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1055/s-2006-960808

Cite this

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title = "Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum",

abstract = "(-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).",

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T1 - Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum

AU - Muñoz, V.

AU - Sauvain, Michel

AU - Mollinedo, P.

AU - Callapa, J.

AU - Rojas, I.

AU - Gimenez, A.

AU - Valentin, A.

AU - Mallié, M.

PY - 1999

Y1 - 1999

N2 - (-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).

AB - (-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).

UR - https://www.scopus.com/pages/publications/0032994522

U2 - 10.1055/s-2006-960808

DO - 10.1055/s-2006-960808

M3 - Artículo

C2 - 10418333

AN - SCOPUS:0032994522

SN - 0032-0943

VL - 65

SP - 448

EP - 449

JO - Planta medica

JF - Planta medica

IS - 5

ER -

Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum

Abstract

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