Antimalarial activity of alkaloids from Pogonopus tubulosus

Michel Sauvain; Christian Moretti; José Antonio Bravo; Jorgia Callapa; Victoria Muñoz; Enma Ruiz; Bernard Richard; Louisette Le Men-Olivier

doi:10.1002/(SICI)1099-1573(199605)10:3<198::AID-PTR798>3.0.CO;2-Z

Antimalarial activity of alkaloids from Pogonopus tubulosus

Michel Sauvain
, Christian Moretti
, José Antonio Bravo
, Jorgia Callapa
, Victoria Muñoz
, Enma Ruiz
, Bernard Richard
, Louisette Le Men-Olivier

Inst. Francais Rech. Sci. pour le D.
Inst. Boliviano de Biol. de Altura
LEGOS, UMR 5566, IRD

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The antimalarial activity of the Bolivian medicinal plant Pogonopus tubulosus (D.C.) Schumann was evaluated by in vitro testing on trophozoite stages of resistant and sensitive strains of Plasmodium falciparum and by in vivo tests on P. berghei send P. vinckei pefteri in mice. The bark of this medicinal plant yielded three alkaloids: tubulosine, psychotrine, cephaeline. Tubulosine showed an interesting activity in vitro with an IC₅₀ of 0.006 μg/ mL against the sensitive strain of P. falciparum and an IC₅₀ of 0.011 μg/mL against the resistant strain of P. falciparum. This compound had good in vivo antimalarial activity with an ED₅₀ of 0.05 mg/kg/day on P. vinckei petteri strain and an ED₅₀ of 0.45 mg/kg/day on P. berghei.

Original language	English
Pages (from-to)	198-201
Number of pages	4
Journal	Phytotherapy Research
Volume	10
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1099-1573(199605)10:3<198::AID-PTR798>3.0.CO;2-Z
State	Published - May 1996
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimalarial
Cephaeline
P. berghei
P. vinckei
Plasmodium falciparum
Pogonopus tubulosus
Psychotrine
Tublosine

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10.1002/(SICI)1099-1573(199605)10:3<198::AID-PTR798>3.0.CO;2-Z

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title = "Antimalarial activity of alkaloids from Pogonopus tubulosus",

abstract = "The antimalarial activity of the Bolivian medicinal plant Pogonopus tubulosus (D.C.) Schumann was evaluated by in vitro testing on trophozoite stages of resistant and sensitive strains of Plasmodium falciparum and by in vivo tests on P. berghei send P. vinckei pefteri in mice. The bark of this medicinal plant yielded three alkaloids: tubulosine, psychotrine, cephaeline. Tubulosine showed an interesting activity in vitro with an IC50 of 0.006 μg/ mL against the sensitive strain of P. falciparum and an IC50 of 0.011 μg/mL against the resistant strain of P. falciparum. This compound had good in vivo antimalarial activity with an ED50 of 0.05 mg/kg/day on P. vinckei petteri strain and an ED50 of 0.45 mg/kg/day on P. berghei.",

keywords = "Antimalarial, Cephaeline, P. berghei, P. vinckei, Plasmodium falciparum, Pogonopus tubulosus, Psychotrine, Tublosine",

author = "Michel Sauvain and Christian Moretti and Bravo, \{Jos{\'e} Antonio\} and Jorgia Callapa and Victoria Mu{\~n}oz and Enma Ruiz and Bernard Richard and \{Le Men-Olivier\}, Louisette",

year = "1996",

month = may,

doi = "10.1002/(SICI)1099-1573(199605)10:3<198::AID-PTR798>3.0.CO;2-Z",

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T1 - Antimalarial activity of alkaloids from Pogonopus tubulosus

AU - Sauvain, Michel

AU - Moretti, Christian

AU - Bravo, José Antonio

AU - Callapa, Jorgia

AU - Muñoz, Victoria

AU - Ruiz, Enma

AU - Richard, Bernard

AU - Le Men-Olivier, Louisette

PY - 1996/5

Y1 - 1996/5

N2 - The antimalarial activity of the Bolivian medicinal plant Pogonopus tubulosus (D.C.) Schumann was evaluated by in vitro testing on trophozoite stages of resistant and sensitive strains of Plasmodium falciparum and by in vivo tests on P. berghei send P. vinckei pefteri in mice. The bark of this medicinal plant yielded three alkaloids: tubulosine, psychotrine, cephaeline. Tubulosine showed an interesting activity in vitro with an IC50 of 0.006 μg/ mL against the sensitive strain of P. falciparum and an IC50 of 0.011 μg/mL against the resistant strain of P. falciparum. This compound had good in vivo antimalarial activity with an ED50 of 0.05 mg/kg/day on P. vinckei petteri strain and an ED50 of 0.45 mg/kg/day on P. berghei.

AB - The antimalarial activity of the Bolivian medicinal plant Pogonopus tubulosus (D.C.) Schumann was evaluated by in vitro testing on trophozoite stages of resistant and sensitive strains of Plasmodium falciparum and by in vivo tests on P. berghei send P. vinckei pefteri in mice. The bark of this medicinal plant yielded three alkaloids: tubulosine, psychotrine, cephaeline. Tubulosine showed an interesting activity in vitro with an IC50 of 0.006 μg/ mL against the sensitive strain of P. falciparum and an IC50 of 0.011 μg/mL against the resistant strain of P. falciparum. This compound had good in vivo antimalarial activity with an ED50 of 0.05 mg/kg/day on P. vinckei petteri strain and an ED50 of 0.45 mg/kg/day on P. berghei.

KW - Antimalarial

KW - Cephaeline

KW - P. berghei

KW - P. vinckei

KW - Plasmodium falciparum

KW - Pogonopus tubulosus

KW - Psychotrine

KW - Tublosine

UR - https://www.scopus.com/pages/publications/0029884092

U2 - 10.1002/(SICI)1099-1573(199605)10:3<198::AID-PTR798>3.0.CO;2-Z

DO - 10.1002/(SICI)1099-1573(199605)10:3<198::AID-PTR798>3.0.CO;2-Z

M3 - Artículo

AN - SCOPUS:0029884092

SN - 0951-418X

VL - 10

SP - 198

EP - 201

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 3

ER -

Antimalarial activity of alkaloids from Pogonopus tubulosus

Abstract

UN SDGs

Keywords

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