Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives

Belén Zarranz; Andrés Jaso; Lidia Moreira Lima; Ignacio Aldana; Antonio Monge; Séverine Maurel; Michel Sauvain

doi:10.1590/S1516-93322006000300005

Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives

Belén Zarranz
, Andrés Jaso
, Lidia Moreira Lima
, Ignacio Aldana
, Antonio Monge
, Séverine Maurel
, Michel Sauvain

University of Navarra
Universidade Federal do Rio de Janeiro
Université de Toulouse

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The in vitro antiplasmodial activity of some 3-trifluoromethyl-2- carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain (chloroquine-resistant) of P. falciparum and the most interesting compounds were then evaluated on MCF7 tumor cells in order to evaluate an index of selectivity. The 7-methyl (2b, 4b, 5b, 6b) and nonsubstituted (3c, 4c, 5c) quinoxaline 1,4-dioxide derivatives presented the best level of activity.

Original language	English
Pages (from-to)	357-361
Number of pages	5
Journal	Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences
Volume	42
Issue number	3
DOIs	https://doi.org/10.1590/S1516-93322006000300005
State	Published - 2006
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimalarial
Chloroquine
MCF7
Quinoxaline

Access to Document

10.1590/S1516-93322006000300005

Cite this

@article{f7ff048dda6a41c6b823dce2410673f5,

title = "Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives",

abstract = "The in vitro antiplasmodial activity of some 3-trifluoromethyl-2- carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain (chloroquine-resistant) of P. falciparum and the most interesting compounds were then evaluated on MCF7 tumor cells in order to evaluate an index of selectivity. The 7-methyl (2b, 4b, 5b, 6b) and nonsubstituted (3c, 4c, 5c) quinoxaline 1,4-dioxide derivatives presented the best level of activity.",

keywords = "Antimalarial, Chloroquine, MCF7, Quinoxaline",

author = "Bel{\'e}n Zarranz and Andr{\'e}s Jaso and Lima, \{Lidia Moreira\} and Ignacio Aldana and Antonio Monge and S{\'e}verine Maurel and Michel Sauvain",

year = "2006",

doi = "10.1590/S1516-93322006000300005",

language = "Ingl{\'e}s",

volume = "42",

pages = "357--361",

journal = "Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences",

issn = "1516-9332",

number = "3",

}

TY - JOUR

T1 - Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives

AU - Zarranz, Belén

AU - Jaso, Andrés

AU - Lima, Lidia Moreira

AU - Aldana, Ignacio

AU - Monge, Antonio

AU - Maurel, Séverine

AU - Sauvain, Michel

PY - 2006

Y1 - 2006

N2 - The in vitro antiplasmodial activity of some 3-trifluoromethyl-2- carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain (chloroquine-resistant) of P. falciparum and the most interesting compounds were then evaluated on MCF7 tumor cells in order to evaluate an index of selectivity. The 7-methyl (2b, 4b, 5b, 6b) and nonsubstituted (3c, 4c, 5c) quinoxaline 1,4-dioxide derivatives presented the best level of activity.

AB - The in vitro antiplasmodial activity of some 3-trifluoromethyl-2- carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain (chloroquine-resistant) of P. falciparum and the most interesting compounds were then evaluated on MCF7 tumor cells in order to evaluate an index of selectivity. The 7-methyl (2b, 4b, 5b, 6b) and nonsubstituted (3c, 4c, 5c) quinoxaline 1,4-dioxide derivatives presented the best level of activity.

KW - Antimalarial

KW - Chloroquine

KW - MCF7

KW - Quinoxaline

UR - https://www.scopus.com/pages/publications/33845483659

U2 - 10.1590/S1516-93322006000300005

DO - 10.1590/S1516-93322006000300005

M3 - Artículo

AN - SCOPUS:33845483659

SN - 1516-9332

VL - 42

SP - 357

EP - 361

JO - Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences

JF - Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences

IS - 3

ER -

Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this