Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population

C. A. Taype; J. C. Castro; R. A. Accinelli; P. Herrera-Velit; M. A. Shaw; J. R. Espinoza

doi:10.1016/j.meegid.2006.01.002

Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population

C. A. Taype
, J. C. Castro
, R. A. Accinelli
, P. Herrera-Velit
, M. A. Shaw
, J. R. Espinoza

Faculty of Science and Philosophy
Faculty of Medicine
University of Leeds
Peruvian Institute of Nuclear Energy (IPEN)

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Polymorphism in SLC11A1 has been implicated in host susceptibility to tuberculosis. We have studied associations between INT4, D543N, and 3′UTR polymorphisms of SLC11A1 and different clinical forms of TB. Analysis used 507 patients with pulmonary TB, 123 with extra pulmonary TB and 513 controls. INT4 and D543N showed allelic association with pulmonary TB (P = 0.02 and 0.03 respectively). INT4-D543N-3′UTR haplotypes showed an association with pulmonary TB (P = 0.03). No association of SLC11A1 with miliary TB was observed, and a possible association of D543N to the pleural form (P = 0.08) was suggested. These results support association between SLC11A1 and TB, particularly to the common pulmonary form.

Original language	English
Pages (from-to)	361-367
Number of pages	7
Journal	Infection, Genetics and Evolution
Volume	6
Issue number	5
DOIs	https://doi.org/10.1016/j.meegid.2006.01.002
State	Published - Sep 2006
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Allelic association
Miliary
Pleural
Pulmonary
SLC11A1
Tuberculosis

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10.1016/j.meegid.2006.01.002

Cite this

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title = "Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population",

abstract = "Polymorphism in SLC11A1 has been implicated in host susceptibility to tuberculosis. We have studied associations between INT4, D543N, and 3′UTR polymorphisms of SLC11A1 and different clinical forms of TB. Analysis used 507 patients with pulmonary TB, 123 with extra pulmonary TB and 513 controls. INT4 and D543N showed allelic association with pulmonary TB (P = 0.02 and 0.03 respectively). INT4-D543N-3′UTR haplotypes showed an association with pulmonary TB (P = 0.03). No association of SLC11A1 with miliary TB was observed, and a possible association of D543N to the pleural form (P = 0.08) was suggested. These results support association between SLC11A1 and TB, particularly to the common pulmonary form.",

keywords = "Allelic association, Miliary, Pleural, Pulmonary, SLC11A1, Tuberculosis",

author = "Taype, \{C. A.\} and Castro, \{J. C.\} and Accinelli, \{R. A.\} and P. Herrera-Velit and Shaw, \{M. A.\} and Espinoza, \{J. R.\}",

year = "2006",

month = sep,

doi = "10.1016/j.meegid.2006.01.002",

language = "Ingl{\'e}s",

volume = "6",

pages = "361--367",

journal = "Infection, Genetics and Evolution",

issn = "1567-1348",

number = "5",

}

TY - JOUR

T1 - Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population

AU - Taype, C. A.

AU - Castro, J. C.

AU - Accinelli, R. A.

AU - Herrera-Velit, P.

AU - Shaw, M. A.

AU - Espinoza, J. R.

PY - 2006/9

Y1 - 2006/9

N2 - Polymorphism in SLC11A1 has been implicated in host susceptibility to tuberculosis. We have studied associations between INT4, D543N, and 3′UTR polymorphisms of SLC11A1 and different clinical forms of TB. Analysis used 507 patients with pulmonary TB, 123 with extra pulmonary TB and 513 controls. INT4 and D543N showed allelic association with pulmonary TB (P = 0.02 and 0.03 respectively). INT4-D543N-3′UTR haplotypes showed an association with pulmonary TB (P = 0.03). No association of SLC11A1 with miliary TB was observed, and a possible association of D543N to the pleural form (P = 0.08) was suggested. These results support association between SLC11A1 and TB, particularly to the common pulmonary form.

AB - Polymorphism in SLC11A1 has been implicated in host susceptibility to tuberculosis. We have studied associations between INT4, D543N, and 3′UTR polymorphisms of SLC11A1 and different clinical forms of TB. Analysis used 507 patients with pulmonary TB, 123 with extra pulmonary TB and 513 controls. INT4 and D543N showed allelic association with pulmonary TB (P = 0.02 and 0.03 respectively). INT4-D543N-3′UTR haplotypes showed an association with pulmonary TB (P = 0.03). No association of SLC11A1 with miliary TB was observed, and a possible association of D543N to the pleural form (P = 0.08) was suggested. These results support association between SLC11A1 and TB, particularly to the common pulmonary form.

KW - Allelic association

KW - Miliary

KW - Pleural

KW - Pulmonary

KW - SLC11A1

KW - Tuberculosis

UR - https://www.scopus.com/pages/publications/33745374953

U2 - 10.1016/j.meegid.2006.01.002

DO - 10.1016/j.meegid.2006.01.002

M3 - Artículo

C2 - 16461017

AN - SCOPUS:33745374953

SN - 1567-1348

VL - 6

SP - 361

EP - 367

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

IS - 5

ER -

Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population

Abstract

UN SDGs

Keywords

Access to Document

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