Bioactive acridone alkaloids from Swinglea glutinosa

B. Weniger; B. H. Um; A. Valentin; A. Estrada; A. Lobstein; R. Anton; M. Maillé; M. Sauvain

doi:10.1021/np0005762

Bioactive acridone alkaloids from Swinglea glutinosa

B. Weniger
, B. H. Um
, A. Valentin
, A. Estrada
, A. Lobstein
, R. Anton
, M. Maillé
, M. Sauvain

Université de Strasbourg
Université de Montpellier
Universidad Del Valle
Institut de recherche pour le développement (IRD)

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated alkaloids were assessed in vitro against chloroquine-sensitive and -resistant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.

Original language	English
Pages (from-to)	1221-1223
Number of pages	3
Journal	Journal of Natural Products
Volume	64
Issue number	9
DOIs	https://doi.org/10.1021/np0005762
State	Published - 2001
Externally published	Yes

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10.1021/np0005762

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title = "Bioactive acridone alkaloids from Swinglea glutinosa",

abstract = "A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated alkaloids were assessed in vitro against chloroquine-sensitive and -resistant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.",

author = "B. Weniger and Um, \{B. H.\} and A. Valentin and A. Estrada and A. Lobstein and R. Anton and M. Maill{\'e} and M. Sauvain",

year = "2001",

doi = "10.1021/np0005762",

language = "Ingl{\'e}s",

volume = "64",

pages = "1221--1223",

journal = "Journal of Natural Products",

issn = "0163-3864",

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}

TY - JOUR

T1 - Bioactive acridone alkaloids from Swinglea glutinosa

AU - Weniger, B.

AU - Um, B. H.

AU - Valentin, A.

AU - Estrada, A.

AU - Lobstein, A.

AU - Anton, R.

AU - Maillé, M.

AU - Sauvain, M.

PY - 2001

Y1 - 2001

N2 - A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated alkaloids were assessed in vitro against chloroquine-sensitive and -resistant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.

AB - A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated alkaloids were assessed in vitro against chloroquine-sensitive and -resistant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.

UR - https://www.scopus.com/pages/publications/0034797649

U2 - 10.1021/np0005762

DO - 10.1021/np0005762

M3 - Artículo

C2 - 11575960

AN - SCOPUS:0034797649

SN - 0163-3864

VL - 64

SP - 1221

EP - 1223

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Bioactive acridone alkaloids from Swinglea glutinosa

Abstract

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