CLINICAL AND MICROBIOLOGICAL CHAR ACTERISTICS OF PEDIATRIC PATIENTS HOSPITALIZED FOR PNEUMOCOCCAL PNEUMONIA BEFORE AND AFTER THE INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINES

Carolina Allison Gomez Vasquez; Brayan E. Gonzales; Roger A. Hernández; Francisco Campos; Eduardo Chaparro; Olguita Del Águila; María E. Castillo; Andrés Saenz; Isabel Reyes; Theresa J. Ochoa

doi:10.17843/rpmesp.2025.421.13847

CLINICAL AND MICROBIOLOGICAL CHAR ACTERISTICS OF PEDIATRIC PATIENTS HOSPITALIZED FOR PNEUMOCOCCAL PNEUMONIA BEFORE AND AFTER THE INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINES

Carolina Allison Gomez Vasquez
, Brayan E. Gonzales
, Roger A. Hernández
, Francisco Campos
, Eduardo Chaparro
, Olguita Del Águila
, María E. Castillo
, Andrés Saenz
, Isabel Reyes
, Theresa J. Ochoa

School of Medicine

Universidad Peruana Cayetano Heredia
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt
Hospital Nacional Cayetano Heredia
San Bartolomé National Teaching Hospital for Mothers and Children
Hospital Nacionale Edgardo Rebagliati
Instituto Nacional de Salud Del Niño
Hospital Nacional Daniel Alcides Carrion
Hospital de Emergencias Pediátricas

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The clinical and microbiological characteristics of pneumococcal pneumonia in children hospitalized in Lima were analyzed, before and after the introduction of pneumococcal conjugate vaccines (PCV). We reviewed cases that occurred between 2006-2019, in the pre-PCV7 (2006-2008), post-PCV7 (2009-2011) and post-PCV13 (2016-2019) periods. Of 128 patients with positive cultures (92 blood and 36 pleural fluid), most were infants in the pre-PCV7 (77.1%) and post-PCV7 (43.3%) studies, while in the post-PCV13 study they were mostly preschoolers (62%). We found an increase in complicated pneumonia cases from 14.6% to 72% and an increase in serotype 19A (6.3% to 68%). The most frequent sequence type was ST320 (31 isolates). Resistance to penicillin and ceftriaxone was low (6% and 2%, respectively), although higher in empyema (21.4% and 14.3%, respectively). Resistance to azithromycin increased from 27% to 92%. Penicillin remains the antibiotic of choice for the treatment of uncomplicated pneumococcal pneumonia in Lima.

Translated title of the contribution	Características clínicas y microbiológicas de pacientes pediátricos hospitalizados por neumonía neumocócica antes y después de la introducción de las vacunas conjugadas neumocócicas
Original language	English
Pages (from-to)	63-69
Number of pages	7
Journal	Revista Peruana de Medicina Experimental y Salud Publica
Volume	42
Issue number	1
DOIs	https://doi.org/10.17843/rpmesp.2025.421.13847
State	Published - 1 Jan 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Children
Empyema
Lima
Pneumococcal Pneumonia
Pneumococcal Vaccines

Access to Document

10.17843/rpmesp.2025.421.13847

Cite this

Gomez Vasquez, C. A., Gonzales, B. E., Hernández, R. A., Campos, F., Chaparro, E., Del Águila, O., Castillo, M. E., Saenz, A., Reyes, I., & Ochoa, T. J. (2025). CLINICAL AND MICROBIOLOGICAL CHAR ACTERISTICS OF PEDIATRIC PATIENTS HOSPITALIZED FOR PNEUMOCOCCAL PNEUMONIA BEFORE AND AFTER THE INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINES. Revista Peruana de Medicina Experimental y Salud Publica, 42(1), 63-69. https://doi.org/10.17843/rpmesp.2025.421.13847

@article{7e3c847331fc44f9be07e60da1e90325,

title = "CLINICAL AND MICROBIOLOGICAL CHAR ACTERISTICS OF PEDIATRIC PATIENTS HOSPITALIZED FOR PNEUMOCOCCAL PNEUMONIA BEFORE AND AFTER THE INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINES",

abstract = "The clinical and microbiological characteristics of pneumococcal pneumonia in children hospitalized in Lima were analyzed, before and after the introduction of pneumococcal conjugate vaccines (PCV). We reviewed cases that occurred between 2006-2019, in the pre-PCV7 (2006-2008), post-PCV7 (2009-2011) and post-PCV13 (2016-2019) periods. Of 128 patients with positive cultures (92 blood and 36 pleural fluid), most were infants in the pre-PCV7 (77.1\%) and post-PCV7 (43.3\%) studies, while in the post-PCV13 study they were mostly preschoolers (62\%). We found an increase in complicated pneumonia cases from 14.6\% to 72\% and an increase in serotype 19A (6.3\% to 68\%). The most frequent sequence type was ST320 (31 isolates). Resistance to penicillin and ceftriaxone was low (6\% and 2\%, respectively), although higher in empyema (21.4\% and 14.3\%, respectively). Resistance to azithromycin increased from 27\% to 92\%. Penicillin remains the antibiotic of choice for the treatment of uncomplicated pneumococcal pneumonia in Lima.",

keywords = "Children, Empyema, Lima, Pneumococcal Pneumonia, Pneumococcal Vaccines",

author = "\{Gomez Vasquez\}, \{Carolina Allison\} and Gonzales, \{Brayan E.\} and Hern{\'a}ndez, \{Roger A.\} and Francisco Campos and Eduardo Chaparro and \{Del {\'A}guila\}, Olguita and Castillo, \{Mar{\'i}a E.\} and Andr{\'e}s Saenz and Isabel Reyes and Ochoa, \{Theresa J.\}",

note = "Publisher Copyright: {\textcopyright} 2025, Revista Peruana de Medicina Experimental y Salud P{\'u}blica.",

year = "2025",

month = jan,

day = "1",

doi = "10.17843/rpmesp.2025.421.13847",

language = "Ingl{\'e}s",

volume = "42",

pages = "63--69",

journal = "Revista Peruana de Medicina Experimental y Salud Publica",

issn = "1726-4634",

number = "1",

}

Gomez Vasquez, CA, Gonzales, BE, Hernández, RA, Campos, F, Chaparro, E, Del Águila, O, Castillo, ME, Saenz, A, Reyes, I & Ochoa, TJ 2025, 'CLINICAL AND MICROBIOLOGICAL CHAR ACTERISTICS OF PEDIATRIC PATIENTS HOSPITALIZED FOR PNEUMOCOCCAL PNEUMONIA BEFORE AND AFTER THE INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINES', Revista Peruana de Medicina Experimental y Salud Publica, vol. 42, no. 1, pp. 63-69. https://doi.org/10.17843/rpmesp.2025.421.13847

CLINICAL AND MICROBIOLOGICAL CHAR ACTERISTICS OF PEDIATRIC PATIENTS HOSPITALIZED FOR PNEUMOCOCCAL PNEUMONIA BEFORE AND AFTER THE INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINES. / Gomez Vasquez, Carolina Allison; Gonzales, Brayan E.; Hernández, Roger A. et al.
In: Revista Peruana de Medicina Experimental y Salud Publica, Vol. 42, No. 1, 01.01.2025, p. 63-69.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - CLINICAL AND MICROBIOLOGICAL CHAR ACTERISTICS OF PEDIATRIC PATIENTS HOSPITALIZED FOR PNEUMOCOCCAL PNEUMONIA BEFORE AND AFTER THE INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINES

AU - Gomez Vasquez, Carolina Allison

AU - Gonzales, Brayan E.

AU - Hernández, Roger A.

AU - Campos, Francisco

AU - Chaparro, Eduardo

AU - Del Águila, Olguita

AU - Castillo, María E.

AU - Saenz, Andrés

AU - Reyes, Isabel

AU - Ochoa, Theresa J.

PY - 2025/1/1

Y1 - 2025/1/1

N2 - The clinical and microbiological characteristics of pneumococcal pneumonia in children hospitalized in Lima were analyzed, before and after the introduction of pneumococcal conjugate vaccines (PCV). We reviewed cases that occurred between 2006-2019, in the pre-PCV7 (2006-2008), post-PCV7 (2009-2011) and post-PCV13 (2016-2019) periods. Of 128 patients with positive cultures (92 blood and 36 pleural fluid), most were infants in the pre-PCV7 (77.1%) and post-PCV7 (43.3%) studies, while in the post-PCV13 study they were mostly preschoolers (62%). We found an increase in complicated pneumonia cases from 14.6% to 72% and an increase in serotype 19A (6.3% to 68%). The most frequent sequence type was ST320 (31 isolates). Resistance to penicillin and ceftriaxone was low (6% and 2%, respectively), although higher in empyema (21.4% and 14.3%, respectively). Resistance to azithromycin increased from 27% to 92%. Penicillin remains the antibiotic of choice for the treatment of uncomplicated pneumococcal pneumonia in Lima.

AB - The clinical and microbiological characteristics of pneumococcal pneumonia in children hospitalized in Lima were analyzed, before and after the introduction of pneumococcal conjugate vaccines (PCV). We reviewed cases that occurred between 2006-2019, in the pre-PCV7 (2006-2008), post-PCV7 (2009-2011) and post-PCV13 (2016-2019) periods. Of 128 patients with positive cultures (92 blood and 36 pleural fluid), most were infants in the pre-PCV7 (77.1%) and post-PCV7 (43.3%) studies, while in the post-PCV13 study they were mostly preschoolers (62%). We found an increase in complicated pneumonia cases from 14.6% to 72% and an increase in serotype 19A (6.3% to 68%). The most frequent sequence type was ST320 (31 isolates). Resistance to penicillin and ceftriaxone was low (6% and 2%, respectively), although higher in empyema (21.4% and 14.3%, respectively). Resistance to azithromycin increased from 27% to 92%. Penicillin remains the antibiotic of choice for the treatment of uncomplicated pneumococcal pneumonia in Lima.

KW - Children

KW - Empyema

KW - Lima

KW - Pneumococcal Pneumonia

KW - Pneumococcal Vaccines

UR - https://www.scopus.com/pages/publications/105008529401

U2 - 10.17843/rpmesp.2025.421.13847

DO - 10.17843/rpmesp.2025.421.13847

M3 - Artículo

C2 - 40498936

AN - SCOPUS:105008529401

SN - 1726-4634

VL - 42

SP - 63

EP - 69

JO - Revista Peruana de Medicina Experimental y Salud Publica

JF - Revista Peruana de Medicina Experimental y Salud Publica

IS - 1

ER -

Gomez Vasquez CA, Gonzales BE, Hernández RA, Campos F, Chaparro E, Del Águila O et al. CLINICAL AND MICROBIOLOGICAL CHAR ACTERISTICS OF PEDIATRIC PATIENTS HOSPITALIZED FOR PNEUMOCOCCAL PNEUMONIA BEFORE AND AFTER THE INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINES. Revista Peruana de Medicina Experimental y Salud Publica. 2025 Jan 1;42(1):63-69. doi: 10.17843/rpmesp.2025.421.13847

CLINICAL AND MICROBIOLOGICAL CHAR ACTERISTICS OF PEDIATRIC PATIENTS HOSPITALIZED FOR PNEUMOCOCCAL PNEUMONIA BEFORE AND AFTER THE INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINES

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Cite this