Cordiosides A and B, two new 19-hydroxy-29-norlanostane glycosides isolated from the flowers of Cordia lutea

Inés Y. Castro Dionicio; Nicolas Fabre; Nathalie Saffon-Merceron; Michel Sauvain; Denis Castillo; Valérie Jullian

doi:10.1016/j.phytol.2022.08.015

Cordiosides A and B, two new 19-hydroxy-29-norlanostane glycosides isolated from the flowers of Cordia lutea

Inés Y. Castro Dionicio
, Nicolas Fabre
, Nathalie Saffon-Merceron
, Michel Sauvain
, Denis Castillo
, Valérie Jullian

School of Science and Engineering

Université de Toulouse
Universidad Peruana Cayetano Heredia
Institut de Chimie de Toulouse

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We present here the isolation and structural characterization of two undescribed mono-glycosylated triterpenes with a 19-hydroxy-29-norlanostane core. These compounds (1-2) were isolated from an ethanolic extract of the dried flowers of Cordia lutea, a widely used Peruvian traditional medicine. Their structures were determined by examination of their NMR and MS data. For compound 1, its structure was confirmed by single crystal X-ray structural analyses. 1 showed moderate activity against Helicobacter pylori (MIC = 15.6 µg/mL), and was not active against Escherichia coli, Pseudomonas aeruginosa or Staphylococcus aureus (MIC > 125 µg/mL).

Original language	English
Pages (from-to)	40-44
Number of pages	5
Journal	Phytochemistry Letters
Volume	52
DOIs	https://doi.org/10.1016/j.phytol.2022.08.015
State	Published - Dec 2022

Keywords

19-Hydroxy-29-norlanostane
Antibacterial
Boraginaceae
Cordia lutea
Helicobacter pylori
Peruvian traditional medicine

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10.1016/j.phytol.2022.08.015

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title = "Cordiosides A and B, two new 19-hydroxy-29-norlanostane glycosides isolated from the flowers of Cordia lutea",

abstract = "We present here the isolation and structural characterization of two undescribed mono-glycosylated triterpenes with a 19-hydroxy-29-norlanostane core. These compounds (1-2) were isolated from an ethanolic extract of the dried flowers of Cordia lutea, a widely used Peruvian traditional medicine. Their structures were determined by examination of their NMR and MS data. For compound 1, its structure was confirmed by single crystal X-ray structural analyses. 1 showed moderate activity against Helicobacter pylori (MIC = 15.6 µg/mL), and was not active against Escherichia coli, Pseudomonas aeruginosa or Staphylococcus aureus (MIC > 125 µg/mL).",

keywords = "19-Hydroxy-29-norlanostane, Antibacterial, Boraginaceae, Cordia lutea, Helicobacter pylori, Peruvian traditional medicine",

author = "\{Castro Dionicio\}, \{In{\'e}s Y.\} and Nicolas Fabre and Nathalie Saffon-Merceron and Michel Sauvain and Denis Castillo and Val{\'e}rie Jullian",

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year = "2022",

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doi = "10.1016/j.phytol.2022.08.015",

language = "Ingl{\'e}s",

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journal = "Phytochemistry Letters",

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TY - JOUR

T1 - Cordiosides A and B, two new 19-hydroxy-29-norlanostane glycosides isolated from the flowers of Cordia lutea

AU - Castro Dionicio, Inés Y.

AU - Fabre, Nicolas

AU - Saffon-Merceron, Nathalie

AU - Sauvain, Michel

AU - Castillo, Denis

AU - Jullian, Valérie

PY - 2022/12

Y1 - 2022/12

N2 - We present here the isolation and structural characterization of two undescribed mono-glycosylated triterpenes with a 19-hydroxy-29-norlanostane core. These compounds (1-2) were isolated from an ethanolic extract of the dried flowers of Cordia lutea, a widely used Peruvian traditional medicine. Their structures were determined by examination of their NMR and MS data. For compound 1, its structure was confirmed by single crystal X-ray structural analyses. 1 showed moderate activity against Helicobacter pylori (MIC = 15.6 µg/mL), and was not active against Escherichia coli, Pseudomonas aeruginosa or Staphylococcus aureus (MIC > 125 µg/mL).

AB - We present here the isolation and structural characterization of two undescribed mono-glycosylated triterpenes with a 19-hydroxy-29-norlanostane core. These compounds (1-2) were isolated from an ethanolic extract of the dried flowers of Cordia lutea, a widely used Peruvian traditional medicine. Their structures were determined by examination of their NMR and MS data. For compound 1, its structure was confirmed by single crystal X-ray structural analyses. 1 showed moderate activity against Helicobacter pylori (MIC = 15.6 µg/mL), and was not active against Escherichia coli, Pseudomonas aeruginosa or Staphylococcus aureus (MIC > 125 µg/mL).

KW - 19-Hydroxy-29-norlanostane

KW - Antibacterial

KW - Boraginaceae

KW - Cordia lutea

KW - Helicobacter pylori

KW - Peruvian traditional medicine

UR - https://www.scopus.com/pages/publications/85138032140

U2 - 10.1016/j.phytol.2022.08.015

DO - 10.1016/j.phytol.2022.08.015

M3 - Artículo

AN - SCOPUS:85138032140

SN - 1874-3900

VL - 52

SP - 40

EP - 44

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Cordiosides A and B, two new 19-hydroxy-29-norlanostane glycosides isolated from the flowers of Cordia lutea

Abstract

Keywords

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