CRISPRi-mediated repression of efflux pumps reveals Rv1258c as a key contributor to pyrazinamide resistance in Mycobacterium tuberculosis

Flores B. Carlos Alonso; Kiara Aricoche-Del Campo; Robert H. Gilman; Mirko Zimic; Patricia Sheen

doi:10.1016/j.tube.2025.102665

CRISPRi-mediated repression of efflux pumps reveals Rv1258c as a key contributor to pyrazinamide resistance in Mycobacterium tuberculosis

Flores B. Carlos Alonso
, Kiara Aricoche-Del Campo
, Robert H. Gilman
, Mirko Zimic
, Patricia Sheen

School of Science and Engineering

Universidad Peruana Cayetano Heredia
Johns Hopkins Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Original language	English
Article number	102665
Journal	Tuberculosis
Volume	154
DOIs	https://doi.org/10.1016/j.tube.2025.102665
State	Published - Sep 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.tube.2025.102665

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title = "CRISPRi-mediated repression of efflux pumps reveals Rv1258c as a key contributor to pyrazinamide resistance in Mycobacterium tuberculosis",

author = "\{Carlos Alonso\}, \{Flores B.\} and \{Aricoche-Del Campo\}, Kiara and Gilman, \{Robert H.\} and Mirko Zimic and Patricia Sheen",

year = "2025",

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doi = "10.1016/j.tube.2025.102665",

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T1 - CRISPRi-mediated repression of efflux pumps reveals Rv1258c as a key contributor to pyrazinamide resistance in Mycobacterium tuberculosis

AU - Carlos Alonso, Flores B.

AU - Aricoche-Del Campo, Kiara

AU - Gilman, Robert H.

AU - Zimic, Mirko

AU - Sheen, Patricia

PY - 2025/9

Y1 - 2025/9

UR - https://www.scopus.com/pages/publications/105008767616

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DO - 10.1016/j.tube.2025.102665

M3 - Artículo

C2 - 40570617

AN - SCOPUS:105008767616

SN - 1472-9792

VL - 154

JO - Tuberculosis

JF - Tuberculosis

M1 - 102665

ER -

CRISPRi-mediated repression of efflux pumps reveals Rv1258c as a key contributor to pyrazinamide resistance in Mycobacterium tuberculosis

UN SDGs

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