Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum

José C. Aponte; Zhuang Jin; Abraham J. Vaisberg; Denis Castillo; Edith Málaga; Walter H. Lewis; Michel Sauvain; Robert H. Gilman; Gerald B. Hammond

doi:10.1055/s-0030-1270960

Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum

José C. Aponte
, Zhuang Jin
, Abraham J. Vaisberg
, Denis Castillo
, Edith Málaga
, Walter H. Lewis
, Michel Sauvain
, Robert H. Gilman
, Gerald B. Hammond

School of Science and Engineering

University of Louisville
Brown University
Universidad Peruana Cayetano Heredia
Washington University School of Medicine
Université de Toulouse
Universidad Peruana Cayetano Heredia, Facultad de Medicina Alberto Hurtado
Johns Hopkins Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

An anticancer-bioassay guided isolation of the ethanol extract and fractions of two plants from the Peruvian rainforest, Mikania decora and Cremastosperma microcarpum, led to the characterization of one abundant diterpene, ent-pimara-8(14),15-dien-19-oic acid (1), three thymol derivatives, 10-acetoxy-8,9-dehydro-6-methoxythymol butyrate (2), 10-acetoxy-8,9-epoxy-6- methoxythymol isobutyrate (3), and acetylschizoginol (4), as well as one neolignan, (±)-trans-dehydrodiisoeugenol (5). Only the latter was isolated from C. microcarpum. These compounds exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 3 and 4 were also investigated for their in vitro antileishmanial and trypanocidal activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes.

Original language	English
Pages (from-to)	1597-1599
Number of pages	3
Journal	Planta medica
Volume	77
Issue number	14
DOIs	https://doi.org/10.1055/s-0030-1270960
State	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Compositae
Cremastosperma microcarpum Annonaceae
Mikania decora
anticancer
antileishmania
trypanoside

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10.1055/s-0030-1270960

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title = "Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum",

abstract = "An anticancer-bioassay guided isolation of the ethanol extract and fractions of two plants from the Peruvian rainforest, Mikania decora and Cremastosperma microcarpum, led to the characterization of one abundant diterpene, ent-pimara-8(14),15-dien-19-oic acid (1), three thymol derivatives, 10-acetoxy-8,9-dehydro-6-methoxythymol butyrate (2), 10-acetoxy-8,9-epoxy-6- methoxythymol isobutyrate (3), and acetylschizoginol (4), as well as one neolignan, (±)-trans-dehydrodiisoeugenol (5). Only the latter was isolated from C. microcarpum. These compounds exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 3 and 4 were also investigated for their in vitro antileishmanial and trypanocidal activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes.",

keywords = "Compositae, Cremastosperma microcarpum Annonaceae, Mikania decora, anticancer, antileishmania, trypanoside",

author = "Aponte, \{Jos{\'e} C.\} and Zhuang Jin and Vaisberg, \{Abraham J.\} and Denis Castillo and Edith M{\'a}laga and Lewis, \{Walter H.\} and Michel Sauvain and Gilman, \{Robert H.\} and Hammond, \{Gerald B.\}",

year = "2011",

doi = "10.1055/s-0030-1270960",

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pages = "1597--1599",

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T1 - Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum

AU - Aponte, José C.

AU - Jin, Zhuang

AU - Vaisberg, Abraham J.

AU - Castillo, Denis

AU - Málaga, Edith

AU - Lewis, Walter H.

AU - Sauvain, Michel

AU - Gilman, Robert H.

AU - Hammond, Gerald B.

PY - 2011

Y1 - 2011

N2 - An anticancer-bioassay guided isolation of the ethanol extract and fractions of two plants from the Peruvian rainforest, Mikania decora and Cremastosperma microcarpum, led to the characterization of one abundant diterpene, ent-pimara-8(14),15-dien-19-oic acid (1), three thymol derivatives, 10-acetoxy-8,9-dehydro-6-methoxythymol butyrate (2), 10-acetoxy-8,9-epoxy-6- methoxythymol isobutyrate (3), and acetylschizoginol (4), as well as one neolignan, (±)-trans-dehydrodiisoeugenol (5). Only the latter was isolated from C. microcarpum. These compounds exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 3 and 4 were also investigated for their in vitro antileishmanial and trypanocidal activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes.

AB - An anticancer-bioassay guided isolation of the ethanol extract and fractions of two plants from the Peruvian rainforest, Mikania decora and Cremastosperma microcarpum, led to the characterization of one abundant diterpene, ent-pimara-8(14),15-dien-19-oic acid (1), three thymol derivatives, 10-acetoxy-8,9-dehydro-6-methoxythymol butyrate (2), 10-acetoxy-8,9-epoxy-6- methoxythymol isobutyrate (3), and acetylschizoginol (4), as well as one neolignan, (±)-trans-dehydrodiisoeugenol (5). Only the latter was isolated from C. microcarpum. These compounds exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 3 and 4 were also investigated for their in vitro antileishmanial and trypanocidal activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes.

KW - Compositae

KW - Cremastosperma microcarpum Annonaceae

KW - Mikania decora

KW - anticancer

KW - antileishmania

KW - trypanoside

UR - https://www.scopus.com/pages/publications/80053310631

U2 - 10.1055/s-0030-1270960

DO - 10.1055/s-0030-1270960

M3 - Artículo

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AN - SCOPUS:80053310631

SN - 0032-0943

VL - 77

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JF - Planta medica

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ER -

Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum

Abstract

UN SDGs

Keywords

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