Cytotoxic and anti-infective sesquiterpenes present in plagiochila disticha (Plagiochilaceae) and ambrosia peruviana (Asteraceae)

José C. Aponte; Han Yang; Abraham J. Vaisberg; Denis Castillo; Edith Málaga; Manuela Verástegui; Lavona K. Casson; Nicole Stivers; Paula J. Bates; Rosario Rojas; Irma Fernandez; Walter H. Lewis; César Sarasara; Michel Sauvain; Robert H. Gilman; Gerald B. Hammond

doi:10.1055/s-0029-1240681

Cytotoxic and anti-infective sesquiterpenes present in plagiochila disticha (Plagiochilaceae) and ambrosia peruviana (Asteraceae)

José C. Aponte
, Han Yang
, Abraham J. Vaisberg
, Denis Castillo
, Edith Málaga
, Manuela Verástegui
, Lavona K. Casson
, Nicole Stivers
, Paula J. Bates
, Rosario Rojas
, Irma Fernandez
, Walter H. Lewis
, César Sarasara
, Michel Sauvain
, Robert H. Gilman
, Gerald B. Hammond

University of Louisville
Universidad Peruana Cayetano Heredia
Washington University School of Medicine
Confederacion de Nacionalidades Amazónicas Del Perú
Université de Toulouse
Johns Hopkins Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, Plagiochila disticha and Ambrosia peruviana, led to the isolation and characterization of three ent-2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A (1), I (2), and R (3), as well as of two pseudoguaianolids, damsin (4) and confertin (5), which exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 1, 4, and 5 were also investigated for their in vitro antileishmanial, trypanocidal, and antituberculosis activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes, as well as against MDR and sensitive strains of Mycobacterium tuberculosis, respectively.

Original language	English
Pages (from-to)	705-707
Number of pages	3
Journal	Planta medica
Volume	76
Issue number	7
DOIs	https://doi.org/10.1055/s-0029-1240681
State	Published - 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Ambrosia peruviana
Antileishmania
Asteraceae
Cytotoxic
Plagiochila disticha
Plagiochilaceae
Trypanoside
Tuberculosis

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10.1055/s-0029-1240681

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Aponte, J. C., Yang, H., Vaisberg, A. J., Castillo, D., Málaga, E., Verástegui, M., Casson, L. K., Stivers, N., Bates, P. J., Rojas, R., Fernandez, I., Lewis, W. H., Sarasara, C., Sauvain, M., Gilman, R. H., & Hammond, G. B. (2010). Cytotoxic and anti-infective sesquiterpenes present in plagiochila disticha (Plagiochilaceae) and ambrosia peruviana (Asteraceae). Planta medica, 76(7), 705-707. https://doi.org/10.1055/s-0029-1240681

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title = "Cytotoxic and anti-infective sesquiterpenes present in plagiochila disticha (Plagiochilaceae) and ambrosia peruviana (Asteraceae)",

abstract = "A pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, Plagiochila disticha and Ambrosia peruviana, led to the isolation and characterization of three ent-2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A (1), I (2), and R (3), as well as of two pseudoguaianolids, damsin (4) and confertin (5), which exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 1, 4, and 5 were also investigated for their in vitro antileishmanial, trypanocidal, and antituberculosis activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes, as well as against MDR and sensitive strains of Mycobacterium tuberculosis, respectively.",

keywords = "Ambrosia peruviana, Antileishmania, Asteraceae, Cytotoxic, Plagiochila disticha, Plagiochilaceae, Trypanoside, Tuberculosis",

author = "Aponte, \{Jos{\'e} C.\} and Han Yang and Vaisberg, \{Abraham J.\} and Denis Castillo and Edith M{\'a}laga and Manuela Ver{\'a}stegui and Casson, \{Lavona K.\} and Nicole Stivers and Bates, \{Paula J.\} and Rosario Rojas and Irma Fernandez and Lewis, \{Walter H.\} and C{\'e}sar Sarasara and Michel Sauvain and Gilman, \{Robert H.\} and Hammond, \{Gerald B.\}",

year = "2010",

doi = "10.1055/s-0029-1240681",

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Aponte, JC, Yang, H, Vaisberg, AJ , Castillo, D, Málaga, E, Verástegui, M, Casson, LK, Stivers, N, Bates, PJ, Rojas, R, Fernandez, I, Lewis, WH, Sarasara, C, Sauvain, M, Gilman, RH & Hammond, GB 2010, 'Cytotoxic and anti-infective sesquiterpenes present in plagiochila disticha (Plagiochilaceae) and ambrosia peruviana (Asteraceae)', Planta medica, vol. 76, no. 7, pp. 705-707. https://doi.org/10.1055/s-0029-1240681

TY - JOUR

T1 - Cytotoxic and anti-infective sesquiterpenes present in plagiochila disticha (Plagiochilaceae) and ambrosia peruviana (Asteraceae)

AU - Aponte, José C.

AU - Yang, Han

AU - Vaisberg, Abraham J.

AU - Castillo, Denis

AU - Málaga, Edith

AU - Verástegui, Manuela

AU - Casson, Lavona K.

AU - Stivers, Nicole

AU - Bates, Paula J.

AU - Rojas, Rosario

AU - Fernandez, Irma

AU - Lewis, Walter H.

AU - Sarasara, César

AU - Sauvain, Michel

AU - Gilman, Robert H.

AU - Hammond, Gerald B.

PY - 2010

Y1 - 2010

N2 - A pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, Plagiochila disticha and Ambrosia peruviana, led to the isolation and characterization of three ent-2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A (1), I (2), and R (3), as well as of two pseudoguaianolids, damsin (4) and confertin (5), which exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 1, 4, and 5 were also investigated for their in vitro antileishmanial, trypanocidal, and antituberculosis activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes, as well as against MDR and sensitive strains of Mycobacterium tuberculosis, respectively.

AB - A pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, Plagiochila disticha and Ambrosia peruviana, led to the isolation and characterization of three ent-2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A (1), I (2), and R (3), as well as of two pseudoguaianolids, damsin (4) and confertin (5), which exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 1, 4, and 5 were also investigated for their in vitro antileishmanial, trypanocidal, and antituberculosis activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes, as well as against MDR and sensitive strains of Mycobacterium tuberculosis, respectively.

KW - Ambrosia peruviana

KW - Antileishmania

KW - Asteraceae

KW - Cytotoxic

KW - Plagiochila disticha

KW - Plagiochilaceae

KW - Trypanoside

KW - Tuberculosis

UR - https://www.scopus.com/pages/publications/77952076256

U2 - 10.1055/s-0029-1240681

DO - 10.1055/s-0029-1240681

M3 - Artículo

C2 - 19960415

AN - SCOPUS:77952076256

SN - 0032-0943

VL - 76

SP - 705

EP - 707

JO - Planta medica

JF - Planta medica

IS - 7

ER -

Cytotoxic and anti-infective sesquiterpenes present in plagiochila disticha (Plagiochilaceae) and ambrosia peruviana (Asteraceae)

Abstract

UN SDGs

Keywords

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