Cytotoxic triterpene acids from the peruvian medicinal plant Polylepis racemosa

Catherine C. Neto; Abraham J. Vaisberg; Bing Nan Zhou; David G.I. Kingston; Gerald B. Hammond

doi:10.1055/s-2000-8583

Cytotoxic triterpene acids from the peruvian medicinal plant Polylepis racemosa

Catherine C. Neto
, Abraham J. Vaisberg
, Bing Nan Zhou
, David G.I. Kingston
, Gerald B. Hammond

School of Science and Engineering

Univ. of Massachusetts-Dartmouth
Department of Fish and Wildlife Conservation

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI₅₀ values of 6,9 and 8.3/μg/mL respectively.

Original language	English
Pages (from-to)	483-484
Number of pages	2
Journal	Planta medica
Volume	66
Issue number	5
DOIs	https://doi.org/10.1055/s-2000-8583
State	Published - 2000

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1055/s-2000-8583

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abstract = "Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6,9 and 8.3/μg/mL respectively.",

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AU - Neto, Catherine C.

AU - Vaisberg, Abraham J.

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AU - Kingston, David G.I.

AU - Hammond, Gerald B.

PY - 2000

Y1 - 2000

N2 - Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6,9 and 8.3/μg/mL respectively.

AB - Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6,9 and 8.3/μg/mL respectively.

UR - https://www.scopus.com/pages/publications/3242773879

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DO - 10.1055/s-2000-8583

M3 - Artículo

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AN - SCOPUS:3242773879

SN - 0032-0943

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JO - Planta medica

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ER -

Cytotoxic triterpene acids from the peruvian medicinal plant Polylepis racemosa

Abstract

UN SDGs

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