Efecto de la maca roja (Lepidium meyenii) sobre los niveles de IFN-γ en ratas ovariectomizadas

Johanna Leiva-Revilla; Félix Guerra-Castañon; Paola Olcese-Mori; Ivan Lozada; Julio Rubio; Carla Gonzales; Gustavo F. Gonzales

Efecto de la maca roja (Lepidium meyenii) sobre los niveles de IFN-γ en ratas ovariectomizadas

Translated title of the contribution: Effect of red maca (Lepidium meyenii) on IFN-γ levels in ovariectomized rats

Johanna Leiva-Revilla
, Félix Guerra-Castañon
, Paola Olcese-Mori
, Ivan Lozada
, Julio Rubio
, Carla Gonzales
, Gustavo F. Gonzales

Universidad Peruana Cayetano Heredia

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objectives. Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX). Materials and methods. Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized rats (PO); Group 2: OVX rats; Group 3: OVX rats treated with 4 ug/kg estradiol; and Group 4, 5 and 6: OVX rats treated with red maca extracts with 2.15, 4.3 and 8.6 mg polyphenols/body weight kilogram, respectively. Results. OVX rats showed low levels of IFN-γ compared to PO rats. Estradiol and red maca reversed the effect of ovariectomy on the IFN-γ levels. A positive dose-response effect of red maca on IFN-γ levels was shown (r = 0.57, p <0.05). Conclusions. Red maca administration increases levels of IFN-γ in ovariectomized rats.

Translated title of the contribution	Effect of red maca (Lepidium meyenii) on IFN-γ levels in ovariectomized rats
Original language	Spanish
Pages (from-to)	683-688
Number of pages	6
Journal	Revista Peruana de Medicina Experimental y Salud Publica
Volume	31
Issue number	4
State	Published - 2014

Cite this

@article{3ad9f174878d44fe86966020d9f0e7d1,

title = "Efecto de la maca roja (Lepidium meyenii) sobre los niveles de IFN-γ en ratas ovariectomizadas",

abstract = "Objectives. Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX). Materials and methods. Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized rats (PO); Group 2: OVX rats; Group 3: OVX rats treated with 4 ug/kg estradiol; and Group 4, 5 and 6: OVX rats treated with red maca extracts with 2.15, 4.3 and 8.6 mg polyphenols/body weight kilogram, respectively. Results. OVX rats showed low levels of IFN-γ compared to PO rats. Estradiol and red maca reversed the effect of ovariectomy on the IFN-γ levels. A positive dose-response effect of red maca on IFN-γ levels was shown (r = 0.57, p <0.05). Conclusions. Red maca administration increases levels of IFN-γ in ovariectomized rats.",

keywords = "Estradiol (source: MeSH, NLM), Interferon-gamma, Maca, Ovariectomy",

author = "Johanna Leiva-Revilla and F{\'e}lix Guerra-Casta{\~n}on and Paola Olcese-Mori and Ivan Lozada and Julio Rubio and Carla Gonzales and Gonzales, \{Gustavo F.\}",

year = "2014",

language = "Espa{\~n}ol",

volume = "31",

pages = "683--688",

journal = "Revista Peruana de Medicina Experimental y Salud Publica",

issn = "1726-4634",

number = "4",

}

TY - JOUR

T1 - Efecto de la maca roja (Lepidium meyenii) sobre los niveles de IFN-γ en ratas ovariectomizadas

AU - Leiva-Revilla, Johanna

AU - Guerra-Castañon, Félix

AU - Olcese-Mori, Paola

AU - Lozada, Ivan

AU - Rubio, Julio

AU - Gonzales, Carla

AU - Gonzales, Gustavo F.

PY - 2014

Y1 - 2014

N2 - Objectives. Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX). Materials and methods. Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized rats (PO); Group 2: OVX rats; Group 3: OVX rats treated with 4 ug/kg estradiol; and Group 4, 5 and 6: OVX rats treated with red maca extracts with 2.15, 4.3 and 8.6 mg polyphenols/body weight kilogram, respectively. Results. OVX rats showed low levels of IFN-γ compared to PO rats. Estradiol and red maca reversed the effect of ovariectomy on the IFN-γ levels. A positive dose-response effect of red maca on IFN-γ levels was shown (r = 0.57, p <0.05). Conclusions. Red maca administration increases levels of IFN-γ in ovariectomized rats.

AB - Objectives. Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX). Materials and methods. Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized rats (PO); Group 2: OVX rats; Group 3: OVX rats treated with 4 ug/kg estradiol; and Group 4, 5 and 6: OVX rats treated with red maca extracts with 2.15, 4.3 and 8.6 mg polyphenols/body weight kilogram, respectively. Results. OVX rats showed low levels of IFN-γ compared to PO rats. Estradiol and red maca reversed the effect of ovariectomy on the IFN-γ levels. A positive dose-response effect of red maca on IFN-γ levels was shown (r = 0.57, p <0.05). Conclusions. Red maca administration increases levels of IFN-γ in ovariectomized rats.

KW - Estradiol (source: MeSH, NLM)

KW - Interferon-gamma

KW - Maca

KW - Ovariectomy

UR - https://www.scopus.com/pages/publications/84920997358

M3 - Artículo

C2 - 25597718

AN - SCOPUS:84920997358

SN - 1726-4634

VL - 31

SP - 683

EP - 688

JO - Revista Peruana de Medicina Experimental y Salud Publica

JF - Revista Peruana de Medicina Experimental y Salud Publica

IS - 4

ER -

Efecto de la maca roja (Lepidium meyenii) sobre los niveles de IFN-γ en ratas ovariectomizadas

Abstract

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