EFECTOS HEMATOLOGICOS DEL VENENO DE LOXOSCELES LAETA EN RATONES ALBINOS

O. Moran; A. Zavaleta; R. Castro de la Mata

EFECTOS HEMATOLOGICOS DEL VENENO DE LOXOSCELES LAETA EN RATONES ALBINOS

Translated title of the contribution: Hematological effects of Loxosceles-laeta venom in albino mice

O. Moran
, A. Zavaleta
, R. Castro de la Mata

Universidad Peruana Cayetano Heredia

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Following subcutaneous injection of Loxosceles-laeta venom in mice, both the hematocrit and the hemoglobin concentration increased in the peripheral blood. Hemolysis was not detected. Total blood-volume and plasma-volume decreased; fixed globular-volume remained constant. Autopsy showed a generalized edema and ascites, without modifications in total body-weight. These results have shown that mice have a different kind of toxic manifestation compared with those presented in humans. This fact questions the use of mice in assays of protective activity of hyperimmune sera.

Translated title of the contribution	Hematological effects of Loxosceles-laeta venom in albino mice
Original language	Spanish
Pages (from-to)	20-23
Number of pages	4
Journal	Boletin Chileno de Parasitologia
Volume	36
Issue number	1-2
State	Published - 1981

Cite this

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title = "EFECTOS HEMATOLOGICOS DEL VENENO DE LOXOSCELES LAETA EN RATONES ALBINOS",

abstract = "Following subcutaneous injection of Loxosceles-laeta venom in mice, both the hematocrit and the hemoglobin concentration increased in the peripheral blood. Hemolysis was not detected. Total blood-volume and plasma-volume decreased; fixed globular-volume remained constant. Autopsy showed a generalized edema and ascites, without modifications in total body-weight. These results have shown that mice have a different kind of toxic manifestation compared with those presented in humans. This fact questions the use of mice in assays of protective activity of hyperimmune sera.",

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year = "1981",

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T1 - EFECTOS HEMATOLOGICOS DEL VENENO DE LOXOSCELES LAETA EN RATONES ALBINOS

AU - Moran, O.

AU - Zavaleta, A.

AU - Castro de la Mata, R.

PY - 1981

Y1 - 1981

N2 - Following subcutaneous injection of Loxosceles-laeta venom in mice, both the hematocrit and the hemoglobin concentration increased in the peripheral blood. Hemolysis was not detected. Total blood-volume and plasma-volume decreased; fixed globular-volume remained constant. Autopsy showed a generalized edema and ascites, without modifications in total body-weight. These results have shown that mice have a different kind of toxic manifestation compared with those presented in humans. This fact questions the use of mice in assays of protective activity of hyperimmune sera.

AB - Following subcutaneous injection of Loxosceles-laeta venom in mice, both the hematocrit and the hemoglobin concentration increased in the peripheral blood. Hemolysis was not detected. Total blood-volume and plasma-volume decreased; fixed globular-volume remained constant. Autopsy showed a generalized edema and ascites, without modifications in total body-weight. These results have shown that mice have a different kind of toxic manifestation compared with those presented in humans. This fact questions the use of mice in assays of protective activity of hyperimmune sera.

UR - https://www.scopus.com/pages/publications/0019396227

M3 - Artículo

C2 - 7344709

AN - SCOPUS:0019396227

SN - 0365-9402

VL - 36

SP - 20

EP - 23

JO - Boletin Chileno de Parasitologia

JF - Boletin Chileno de Parasitologia

IS - 1-2

ER -

EFECTOS HEMATOLOGICOS DEL VENENO DE LOXOSCELES LAETA EN RATONES ALBINOS

Abstract

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