(+)-epi-α-bisbolol is the wound-healing principle of Peperomia galioides: Investigation of the in vivo wound-healing activity of related terpenoids

L. F. Villegas; A. Marçalo; J. Martin; I. D. Fernández; H. Maldonado; A. J. Vaisberg; G. B. Hammond

doi:10.1021/np0102859

(+)-epi-α-bisbolol is the wound-healing principle of Peperomia galioides: Investigation of the in vivo wound-healing activity of related terpenoids

L. F. Villegas
, A. Marçalo
, J. Martin
, I. D. Fernández
, H. Maldonado
, A. J. Vaisberg
, G. B. Hammond

School of Science and Engineering

Universidad Peruana Cayetano Heredia
Univ. of Massachusetts-Dartmouth

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-α-bisabolol (1) (ED₅₀ 155 μg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, α-bisabolol (2) and α-terpineol (3) (ED₅₀ of 228 and 240 mg/g mouse, respectively).

Original language	English
Pages (from-to)	1357-1359
Number of pages	3
Journal	Journal of Natural Products
Volume	64
Issue number	10
DOIs	https://doi.org/10.1021/np0102859
State	Published - 2001

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title = "(+)-epi-α-bisbolol is the wound-healing principle of Peperomia galioides: Investigation of the in vivo wound-healing activity of related terpenoids",

abstract = "Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-α-bisabolol (1) (ED50 155 μg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, α-bisabolol (2) and α-terpineol (3) (ED50 of 228 and 240 mg/g mouse, respectively).",

author = "Villegas, \{L. F.\} and A. Mar{\c c}alo and J. Martin and Fern{\'a}ndez, \{I. D.\} and H. Maldonado and Vaisberg, \{A. J.\} and Hammond, \{G. B.\}",

year = "2001",

doi = "10.1021/np0102859",

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volume = "64",

pages = "1357--1359",

journal = "Journal of Natural Products",

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T1 - (+)-epi-α-bisbolol is the wound-healing principle of Peperomia galioides

T2 - Investigation of the in vivo wound-healing activity of related terpenoids

AU - Villegas, L. F.

AU - Marçalo, A.

AU - Martin, J.

AU - Fernández, I. D.

AU - Maldonado, H.

AU - Vaisberg, A. J.

AU - Hammond, G. B.

PY - 2001

Y1 - 2001

N2 - Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-α-bisabolol (1) (ED50 155 μg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, α-bisabolol (2) and α-terpineol (3) (ED50 of 228 and 240 mg/g mouse, respectively).

AB - Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-α-bisabolol (1) (ED50 155 μg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, α-bisabolol (2) and α-terpineol (3) (ED50 of 228 and 240 mg/g mouse, respectively).

UR - https://www.scopus.com/pages/publications/0034752655

U2 - 10.1021/np0102859

DO - 10.1021/np0102859

M3 - Artículo

C2 - 11678668

AN - SCOPUS:0034752655

SN - 0163-3864

VL - 64

SP - 1357

EP - 1359

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

(+)-epi-α-bisbolol is the wound-healing principle of Peperomia galioides: Investigation of the in vivo wound-healing activity of related terpenoids

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