Evaluation of A PCR-Based Universal Heteroduplex Generator Assay As A Tool for Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis in Peru

Holger Mayta; Robert H. Gilman; Fanny Arenas; Teresa Valencia; Luz Caviedes; Sonia H. Montenegro; Eduardo Ticona; Jaime Ortiz; Rosa Chumpitaz; Carlton A. Evans; Diana L. Williams

doi:10.1128/JCM.41.12.5774-5777.2003

Evaluation of A PCR-Based Universal Heteroduplex Generator Assay As A Tool for Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis in Peru

Holger Mayta
, Robert H. Gilman
, Fanny Arenas
, Teresa Valencia
, Luz Caviedes
, Sonia H. Montenegro
, Eduardo Ticona
, Jaime Ortiz
, Rosa Chumpitaz
, Carlton A. Evans
, Diana L. Williams

School of Science and Engineering

Johns Hopkins Bloomberg School of Public Health
Universidad Peruana Cayetano Heredia
Asociación Benéfica PRISMA
Ochsner Medical Foundation
Hospital Nacional Dos de Mayo
Hospital María Auxiliadora
Imperial College London
U.S. Department of Health and Human Services

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Multidrug-resistant tuberculosis is an increasing health problem worldwide, especially in developing countries. The PCR-UHG-Rif assay, which detects mutations within the rpoB gene associated with rifampin resistance, was evaluated for its ability and reliability to detect and identify drug-resistant Mycobacterium tuberculosis in a developing country where tuberculosis is highly endemic.

Original language	English
Pages (from-to)	5774-5777
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	41
Issue number	12
DOIs	https://doi.org/10.1128/JCM.41.12.5774-5777.2003
State	Published - Dec 2003

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SDG 3 Good Health and Well-being

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10.1128/JCM.41.12.5774-5777.2003

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Mayta, H., Gilman, R. H., Arenas, F., Valencia, T., Caviedes, L., Montenegro, S. H., Ticona, E., Ortiz, J., Chumpitaz, R., Evans, C. A., & Williams, D. L. (2003). Evaluation of A PCR-Based Universal Heteroduplex Generator Assay As A Tool for Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis in Peru. Journal of Clinical Microbiology, 41(12), 5774-5777. https://doi.org/10.1128/JCM.41.12.5774-5777.2003

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abstract = "Multidrug-resistant tuberculosis is an increasing health problem worldwide, especially in developing countries. The PCR-UHG-Rif assay, which detects mutations within the rpoB gene associated with rifampin resistance, was evaluated for its ability and reliability to detect and identify drug-resistant Mycobacterium tuberculosis in a developing country where tuberculosis is highly endemic.",

author = "Holger Mayta and Gilman, \{Robert H.\} and Fanny Arenas and Teresa Valencia and Luz Caviedes and Montenegro, \{Sonia H.\} and Eduardo Ticona and Jaime Ortiz and Rosa Chumpitaz and Evans, \{Carlton A.\} and Williams, \{Diana L.\}",

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Mayta, H, Gilman, RH, Arenas, F, Valencia, T, Caviedes, L, Montenegro, SH, Ticona, E, Ortiz, J, Chumpitaz, R, Evans, CA & Williams, DL 2003, 'Evaluation of A PCR-Based Universal Heteroduplex Generator Assay As A Tool for Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis in Peru', Journal of Clinical Microbiology, vol. 41, no. 12, pp. 5774-5777. https://doi.org/10.1128/JCM.41.12.5774-5777.2003

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T1 - Evaluation of A PCR-Based Universal Heteroduplex Generator Assay As A Tool for Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis in Peru

AU - Mayta, Holger

AU - Gilman, Robert H.

AU - Arenas, Fanny

AU - Valencia, Teresa

AU - Caviedes, Luz

AU - Montenegro, Sonia H.

AU - Ticona, Eduardo

AU - Ortiz, Jaime

AU - Chumpitaz, Rosa

AU - Evans, Carlton A.

AU - Williams, Diana L.

PY - 2003/12

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AB - Multidrug-resistant tuberculosis is an increasing health problem worldwide, especially in developing countries. The PCR-UHG-Rif assay, which detects mutations within the rpoB gene associated with rifampin resistance, was evaluated for its ability and reliability to detect and identify drug-resistant Mycobacterium tuberculosis in a developing country where tuberculosis is highly endemic.

UR - https://www.scopus.com/pages/publications/10744223420

U2 - 10.1128/JCM.41.12.5774-5777.2003

DO - 10.1128/JCM.41.12.5774-5777.2003

M3 - Artículo

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AN - SCOPUS:10744223420

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ER -

Evaluation of A PCR-Based Universal Heteroduplex Generator Assay As A Tool for Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis in Peru

Abstract

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