Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep

Cesar M. Gavidia; Armando E. Gonzalez; Luis Lopera; Cesar Jayashi; Roxana Angelats; Eduardo A. Barron; Berenice Ninaquispe; Lucia Villarreal; Hector H. Garcia; Manuela R. Verastegui; Robert H. Gilman

doi:10.4269/ajtmh.2009.80.367

Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep

Cesar M. Gavidia
, Armando E. Gonzalez
, Luis Lopera
, Cesar Jayashi
, Roxana Angelats
, Eduardo A. Barron
, Berenice Ninaquispe
, Lucia Villarreal
, Hector H. Garcia
, Manuela R. Verastegui
, Robert H. Gilman

Univ. Nacional Mayor de San Marcos
Johns Hopkins Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Cystic echinococosis (CE) is a public health problem caused by Echinococcus granulosus. We aimed to determine the efficacy of nitazoxanide (NTZ) and oxfendazole (OXF) against CE in naturally infected sheep. A total of 151 ewes were assigned to the following groups: 15 mg/kg of NTZ weekly for five weeks (NTZ5); two rounds of 15 mg/ kg of NTZ a day for five days (NTZ5×2) two weeks apart; 30 mg/kg of OXF a week for 11 weeks (OXF11); 30 mg/kg of OXF plus 15 mg/kg of NTZ a week for 11 weeks (OXF/NTZ); and the control group. OXF11 and OXF/NTZ decreased the number of fertile cysts, increased the number of degenerated cysts, and were more efficacious (49.6-61.2%) against lung cysts and liver cysts (91.8-100%) than any other treatment group. OXF might be an additional strategy for control programs and an optional treatment of human CE after it is licensed.

Original language	English
Pages (from-to)	367-372
Number of pages	6
Journal	American Journal of Tropical Medicine and Hygiene
Volume	80
Issue number	3
DOIs	https://doi.org/10.4269/ajtmh.2009.80.367
State	Published - Mar 2009

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Gavidia, C. M., Gonzalez, A. E., Lopera, L., Jayashi, C., Angelats, R., Barron, E. A., Ninaquispe, B., Villarreal, L., Garcia, H. H., Verastegui, M. R., & Gilman, R. H. (2009). Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep. American Journal of Tropical Medicine and Hygiene, 80(3), 367-372. https://doi.org/10.4269/ajtmh.2009.80.367

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title = "Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep",

abstract = "Cystic echinococosis (CE) is a public health problem caused by Echinococcus granulosus. We aimed to determine the efficacy of nitazoxanide (NTZ) and oxfendazole (OXF) against CE in naturally infected sheep. A total of 151 ewes were assigned to the following groups: 15 mg/kg of NTZ weekly for five weeks (NTZ5); two rounds of 15 mg/ kg of NTZ a day for five days (NTZ5×2) two weeks apart; 30 mg/kg of OXF a week for 11 weeks (OXF11); 30 mg/kg of OXF plus 15 mg/kg of NTZ a week for 11 weeks (OXF/NTZ); and the control group. OXF11 and OXF/NTZ decreased the number of fertile cysts, increased the number of degenerated cysts, and were more efficacious (49.6-61.2\%) against lung cysts and liver cysts (91.8-100\%) than any other treatment group. OXF might be an additional strategy for control programs and an optional treatment of human CE after it is licensed.",

author = "Gavidia, \{Cesar M.\} and Gonzalez, \{Armando E.\} and Luis Lopera and Cesar Jayashi and Roxana Angelats and Barron, \{Eduardo A.\} and Berenice Ninaquispe and Lucia Villarreal and Garcia, \{Hector H.\} and Verastegui, \{Manuela R.\} and Gilman, \{Robert H.\}",

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Gavidia, CM, Gonzalez, AE, Lopera, L, Jayashi, C, Angelats, R, Barron, EA, Ninaquispe, B, Villarreal, L, Garcia, HH , Verastegui, MR & Gilman, RH 2009, 'Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep', American Journal of Tropical Medicine and Hygiene, vol. 80, no. 3, pp. 367-372. https://doi.org/10.4269/ajtmh.2009.80.367

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T1 - Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep

AU - Gavidia, Cesar M.

AU - Gonzalez, Armando E.

AU - Lopera, Luis

AU - Jayashi, Cesar

AU - Angelats, Roxana

AU - Barron, Eduardo A.

AU - Ninaquispe, Berenice

AU - Villarreal, Lucia

AU - Garcia, Hector H.

AU - Verastegui, Manuela R.

AU - Gilman, Robert H.

PY - 2009/3

Y1 - 2009/3

N2 - Cystic echinococosis (CE) is a public health problem caused by Echinococcus granulosus. We aimed to determine the efficacy of nitazoxanide (NTZ) and oxfendazole (OXF) against CE in naturally infected sheep. A total of 151 ewes were assigned to the following groups: 15 mg/kg of NTZ weekly for five weeks (NTZ5); two rounds of 15 mg/ kg of NTZ a day for five days (NTZ5×2) two weeks apart; 30 mg/kg of OXF a week for 11 weeks (OXF11); 30 mg/kg of OXF plus 15 mg/kg of NTZ a week for 11 weeks (OXF/NTZ); and the control group. OXF11 and OXF/NTZ decreased the number of fertile cysts, increased the number of degenerated cysts, and were more efficacious (49.6-61.2%) against lung cysts and liver cysts (91.8-100%) than any other treatment group. OXF might be an additional strategy for control programs and an optional treatment of human CE after it is licensed.

AB - Cystic echinococosis (CE) is a public health problem caused by Echinococcus granulosus. We aimed to determine the efficacy of nitazoxanide (NTZ) and oxfendazole (OXF) against CE in naturally infected sheep. A total of 151 ewes were assigned to the following groups: 15 mg/kg of NTZ weekly for five weeks (NTZ5); two rounds of 15 mg/ kg of NTZ a day for five days (NTZ5×2) two weeks apart; 30 mg/kg of OXF a week for 11 weeks (OXF11); 30 mg/kg of OXF plus 15 mg/kg of NTZ a week for 11 weeks (OXF/NTZ); and the control group. OXF11 and OXF/NTZ decreased the number of fertile cysts, increased the number of degenerated cysts, and were more efficacious (49.6-61.2%) against lung cysts and liver cysts (91.8-100%) than any other treatment group. OXF might be an additional strategy for control programs and an optional treatment of human CE after it is licensed.

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DO - 10.4269/ajtmh.2009.80.367

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SN - 0002-9637

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ER -

Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep

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