Foxp3+ regulatory T cells in antiretroviral-naive HIV patients

Martin Montes; Dorothy E. Lewis; Cesar Sanchez; Diego Lopez De Castilla; Edward A. Graviss; Carlos Seas; Eduardo Gotuzzo; A. Clinton White

doi:10.1097/01.aids.0000238415.98194.38

Foxp3+ regulatory T cells in antiretroviral-naive HIV patients

Martin Montes
, Dorothy E. Lewis
, Cesar Sanchez
, Diego Lopez De Castilla
, Edward A. Graviss
, Carlos Seas
, Eduardo Gotuzzo
, A. Clinton White

Baylor College of Medicine
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

We characterized regulatory T cells from antiretroviral-naive HIV patients by flow cytometry. The proportion of CD4 cells positive for CD25 and Foxp3 was increased, mainly in those with CD4 cell counts less than 200 cells/μl. The total number of Foxp3-positive cells correlated with the CD4 cell count. Further studies are needed on whether Foxp3-positive cell numbers or function explain the susceptibility to autoimmune and inflammatory diseases seen in some patients with advanced HIV.

Original language	English
Pages (from-to)	1669-1671
Number of pages	3
Journal	AIDS
Volume	20
Issue number	12
DOIs	https://doi.org/10.1097/01.aids.0000238415.98194.38
State	Published - Aug 2006

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SDG 3 Good Health and Well-being

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10.1097/01.aids.0000238415.98194.38

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abstract = "We characterized regulatory T cells from antiretroviral-naive HIV patients by flow cytometry. The proportion of CD4 cells positive for CD25 and Foxp3 was increased, mainly in those with CD4 cell counts less than 200 cells/μl. The total number of Foxp3-positive cells correlated with the CD4 cell count. Further studies are needed on whether Foxp3-positive cell numbers or function explain the susceptibility to autoimmune and inflammatory diseases seen in some patients with advanced HIV.",

author = "Martin Montes and Lewis, \{Dorothy E.\} and Cesar Sanchez and \{De Castilla\}, \{Diego Lopez\} and Graviss, \{Edward A.\} and Carlos Seas and Eduardo Gotuzzo and White, \{A. Clinton\}",

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AU - Montes, Martin

AU - Lewis, Dorothy E.

AU - Sanchez, Cesar

AU - De Castilla, Diego Lopez

AU - Graviss, Edward A.

AU - Seas, Carlos

AU - Gotuzzo, Eduardo

AU - White, A. Clinton

PY - 2006/8

Y1 - 2006/8

N2 - We characterized regulatory T cells from antiretroviral-naive HIV patients by flow cytometry. The proportion of CD4 cells positive for CD25 and Foxp3 was increased, mainly in those with CD4 cell counts less than 200 cells/μl. The total number of Foxp3-positive cells correlated with the CD4 cell count. Further studies are needed on whether Foxp3-positive cell numbers or function explain the susceptibility to autoimmune and inflammatory diseases seen in some patients with advanced HIV.

AB - We characterized regulatory T cells from antiretroviral-naive HIV patients by flow cytometry. The proportion of CD4 cells positive for CD25 and Foxp3 was increased, mainly in those with CD4 cell counts less than 200 cells/μl. The total number of Foxp3-positive cells correlated with the CD4 cell count. Further studies are needed on whether Foxp3-positive cell numbers or function explain the susceptibility to autoimmune and inflammatory diseases seen in some patients with advanced HIV.

UR - https://www.scopus.com/pages/publications/33746675679

U2 - 10.1097/01.aids.0000238415.98194.38

DO - 10.1097/01.aids.0000238415.98194.38

M3 - Artículo

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JO - AIDS

JF - AIDS

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ER -

Foxp3+ regulatory T cells in antiretroviral-naive HIV patients

Abstract

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