High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses

Francisco C. Villafuerte; Tatum S. Simonson; Daniela Bermudez; Fabiola Leóon-Velarde

doi:10.1152/physiol.00029.2021

High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses

Francisco C. Villafuerte
, Tatum S. Simonson
, Daniela Bermudez
, Fabiola Leóon-Velarde

School of Science and Engineering

University of California
Universidad Peruana Cayetano Heredia

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

Erythrocytosis, or increased production of red blood cells, is one of the most well-documented physiological traits that varies within and among in high-altitude populations. Although a modest increase in blood O₂-carrying capacity may be beneficial for life in highland environments, erythrocytosis can also become excessive and lead to maladaptive syndromes such as chronic mountain sickness (CMS).

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Physiology
Volume	37
Issue number	4
DOIs	https://doi.org/10.1152/physiol.00029.2021
State	Published - Jul 2022

Keywords

chronic hypoxia
chronic mountain sickness
excessive erythrocytosis
high-altitude erythrocytosis

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10.1152/physiol.00029.2021

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abstract = "Erythrocytosis, or increased production of red blood cells, is one of the most well-documented physiological traits that varies within and among in high-altitude populations. Although a modest increase in blood O2-carrying capacity may be beneficial for life in highland environments, erythrocytosis can also become excessive and lead to maladaptive syndromes such as chronic mountain sickness (CMS).",

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AU - Villafuerte, Francisco C.

AU - Simonson, Tatum S.

AU - Bermudez, Daniela

AU - Leóon-Velarde, Fabiola

PY - 2022/7

Y1 - 2022/7

N2 - Erythrocytosis, or increased production of red blood cells, is one of the most well-documented physiological traits that varies within and among in high-altitude populations. Although a modest increase in blood O2-carrying capacity may be beneficial for life in highland environments, erythrocytosis can also become excessive and lead to maladaptive syndromes such as chronic mountain sickness (CMS).

AB - Erythrocytosis, or increased production of red blood cells, is one of the most well-documented physiological traits that varies within and among in high-altitude populations. Although a modest increase in blood O2-carrying capacity may be beneficial for life in highland environments, erythrocytosis can also become excessive and lead to maladaptive syndromes such as chronic mountain sickness (CMS).

KW - chronic hypoxia

KW - chronic mountain sickness

KW - excessive erythrocytosis

KW - high-altitude erythrocytosis

UR - https://www.scopus.com/pages/publications/85130413941

U2 - 10.1152/physiol.00029.2021

DO - 10.1152/physiol.00029.2021

M3 - Artículo de revisión

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ER -

High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses

Abstract

Keywords

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