HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis

Chloé Loiseau; Daniela Brites; Miriam Reinhard; Kathrin Zürcher; Sonia Borrell; Marie Ballif; Lukas Fenner; Helen Cox; Liliana K. Rutaihwa; Robert J. Wilkinson; Marcel Yotebieng; E. Jane Carter; Alashle Abimiku; Olivier Marcy; Eduardo Gotuzzo; Anchalee Avihingsanon; Nicola Zetola; Basra Doulla; Erik C. Böttger; Matthias Egger; Sebastien Gagneux

doi:10.1128/AAC.00782-20

HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis

Chloé Loiseau
, Daniela Brites
, Miriam Reinhard
, Kathrin Zürcher
, Sonia Borrell
, Marie Ballif
, Lukas Fenner
, Helen Cox
, Liliana K. Rutaihwa
, Robert J. Wilkinson
, Marcel Yotebieng
, E. Jane Carter
, Alashle Abimiku
, Olivier Marcy
, Eduardo Gotuzzo
, Anchalee Avihingsanon
, Nicola Zetola
, Basra Doulla
, Erik C. Böttger
, Matthias Egger

Sebastien Gagneux

Swiss Tropical and Public Health Institute Swiss TPH
University of Basel
Universität Bern
University of Cape Town
Ifakara Health Institute
Imperial College London
Francis Crick Institute
Albert Einstein College of Medicine
Moi Teaching and Referral Hospital
Institute of Human Virology Nigeria
Centre de Prise en Charge de Recherche et de Formation
University of Bordeaux
Chulalongkorn University
University of Pennsylvania
Central Tuberculosis Reference Laboratory, Dar-es-Salaam
National Tuberculosis and Leprosy Programme
University of Zurich
Swiss National Center for Mycobacteria
Faculty of Health Sciences, University of Cape Town

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.

Original language	English
Article number	e00782
Journal	Antimicrobial Agents and Chemotherapy
Volume	64
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00782-20
State	Published - Oct 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Drug resistance
Fitness cost
HIV-TB coinfection
Mycobacterium tuberculosis
Rifampicin

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10.1128/AAC.00782-20

Cite this

Loiseau, C., Brites, D., Reinhard, M., Zürcher, K., Borrell, S., Ballif, M., Fenner, L., Cox, H., Rutaihwa, L. K., Wilkinson, R. J., Yotebieng, M., Jane Carter, E., Abimiku, A., Marcy, O., Gotuzzo, E., Avihingsanon, A., Zetola, N., Doulla, B., Böttger, E. C., ... Gagneux, S. (2020). HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy, 64(10), Article e00782. https://doi.org/10.1128/AAC.00782-20

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title = "HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis",

abstract = "We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.",

keywords = "Drug resistance, Fitness cost, HIV-TB coinfection, Mycobacterium tuberculosis, Rifampicin",

author = "Chlo{\'e} Loiseau and Daniela Brites and Miriam Reinhard and Kathrin Z{\"u}rcher and Sonia Borrell and Marie Ballif and Lukas Fenner and Helen Cox and Rutaihwa, \{Liliana K.\} and Wilkinson, \{Robert J.\} and Marcel Yotebieng and \{Jane Carter\}, E. and Alashle Abimiku and Olivier Marcy and Eduardo Gotuzzo and Anchalee Avihingsanon and Nicola Zetola and Basra Doulla and B{\"o}ttger, \{Erik C.\} and Matthias Egger and Sebastien Gagneux",

note = "Publisher Copyright: Copyright {\textcopyright} 2020 Loiseau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.",

year = "2020",

month = oct,

doi = "10.1128/AAC.00782-20",

language = "Ingl{\'e}s",

volume = "64",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

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Loiseau, C, Brites, D, Reinhard, M, Zürcher, K, Borrell, S, Ballif, M, Fenner, L, Cox, H, Rutaihwa, LK, Wilkinson, RJ, Yotebieng, M, Jane Carter, E, Abimiku, A, Marcy, O, Gotuzzo, E, Avihingsanon, A, Zetola, N, Doulla, B, Böttger, EC, Egger, M & Gagneux, S 2020, 'HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis', Antimicrobial Agents and Chemotherapy, vol. 64, no. 10, e00782. https://doi.org/10.1128/AAC.00782-20

TY - JOUR

T1 - HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis

AU - Loiseau, Chloé

AU - Brites, Daniela

AU - Reinhard, Miriam

AU - Zürcher, Kathrin

AU - Borrell, Sonia

AU - Ballif, Marie

AU - Fenner, Lukas

AU - Cox, Helen

AU - Rutaihwa, Liliana K.

AU - Wilkinson, Robert J.

AU - Yotebieng, Marcel

AU - Jane Carter, E.

AU - Abimiku, Alashle

AU - Marcy, Olivier

AU - Gotuzzo, Eduardo

AU - Avihingsanon, Anchalee

AU - Zetola, Nicola

AU - Doulla, Basra

AU - Böttger, Erik C.

AU - Egger, Matthias

AU - Gagneux, Sebastien

PY - 2020/10

Y1 - 2020/10

N2 - We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.

AB - We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.

KW - Drug resistance

KW - Fitness cost

KW - HIV-TB coinfection

KW - Mycobacterium tuberculosis

KW - Rifampicin

UR - https://www.scopus.com/pages/publications/85091470049

U2 - 10.1128/AAC.00782-20

DO - 10.1128/AAC.00782-20

M3 - Artículo

C2 - 32718966

AN - SCOPUS:85091470049

SN - 0066-4804

VL - 64

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 10

M1 - e00782

ER -

HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis

Abstract

UN SDGs

Keywords

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