In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

José C. Aponte; Denis Castillo; Yannick Estevez; German Gonzalez; Jorge Arevalo; Gerald B. Hammond; Michel Sauvain

doi:10.1016/j.bmcl.2009.11.033

In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

José C. Aponte
, Denis Castillo
, Yannick Estevez
, German Gonzalez
, Jorge Arevalo
, Gerald B. Hammond
, Michel Sauvain

School of Science and Engineering

University of Louisville
Université de Toulouse
Université de Toulouse
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.

Original language	English
Pages (from-to)	100-103
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2009.11.033
State	Published - 1 Jan 2010

Keywords

Anti-Leishmanial drugs
Braziliensis
Chalcone
Leishmania amazonensis
Peruviana

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10.1016/j.bmcl.2009.11.033

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abstract = "The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.",

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AU - Aponte, José C.

AU - Castillo, Denis

AU - Estevez, Yannick

AU - Gonzalez, German

AU - Arevalo, Jorge

AU - Hammond, Gerald B.

AU - Sauvain, Michel

PY - 2010/1/1

Y1 - 2010/1/1

N2 - The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.

AB - The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.

KW - Anti-Leishmanial drugs

KW - Braziliensis

KW - Chalcone

KW - Leishmania amazonensis

KW - Peruviana

UR - https://www.scopus.com/pages/publications/72149098593

U2 - 10.1016/j.bmcl.2009.11.033

DO - 10.1016/j.bmcl.2009.11.033

M3 - Artículo

C2 - 19962891

AN - SCOPUS:72149098593

SN - 0960-894X

VL - 20

SP - 100

EP - 103

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

Abstract

Keywords

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