In vitro antiproliferative activity of palladium(ii) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

Wilfredo Hernández; Abraham J. Vaisberg; Mabel Tobar; Melisa Álvarez; Jorge Manzur; Yuri Echevarría; Evgenia Spodine

doi:10.1039/c5nj02429c

In vitro antiproliferative activity of palladium(ii) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

Wilfredo Hernández
, Abraham J. Vaisberg
, Mabel Tobar
, Melisa Álvarez
, Jorge Manzur
, Yuri Echevarría
, Evgenia Spodine

School of Science and Engineering

Universidad de Lima
Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, CEDENNA
Centro Para El Desarrollo de la Nanociencia y la Nanotecnología (CEDENNA)
Universidad de Chile

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

This work reports the synthesis and characterization of palladium(ii) complexes Pd(L¹)₂ (1), Pd(L²)₂ (2), Pd(L³)₂ (3) and Pd(L⁴)₂ (4), where L¹H: 1-naphthaldehyde thiosemicarbazone; L²H: 4-phenyl-(1-naphthaldehyde)thiosemicarbazone; L³H: (2-hydroxy-1-naphthaldehyde)thiosemicarbazone; L⁴H: 4-phenyl-1-(2-hydroxy-1-naphthaldehyde)thiosemicarbazone. All four complexes show in vitro antiproliferative activity against the following human tumor cell lines: H460, DU145, MCF-7, M14, HT-29, K562, and HuTu 80. In particular Pd(L¹)₂ has the most potent activity for all the studied cell lines (IC₅₀ ∼ 1 μM), with the exception of H460. Pd(L²)₂ is a promising candidate as a pharmacological agent, since it presents a significant activity and is more innocuous than cisplatin against mouse fibroblast normal cells, 3T3. Pd(L⁴)₂ is the complex which exhibits the lowest activity against the same cell line (IC₅₀ ∼ 11 μM), being ten times lower than that of Pd(L¹)₂. These complexes were used to functionalize chitosan coated superparamagnetic magnetite nanoparticles with a metallic core of 11-13 nm, and the activity of these functionalized nanoparticles (NPs) against diverse human tumor cell lines was also tested. The nanoparticles functionalized with Pd(L¹)₂, Pd(L³)₂ and Pd(L⁴)₂ show antiproliferative activity against DU-145, while those with Pd(L²)₂, Pd(L³)₂ and Pd(L⁴)₂ against HuTu80.

Original language	English
Pages (from-to)	1853-1860
Number of pages	8
Journal	New Journal of Chemistry
Volume	40
Issue number	2
DOIs	https://doi.org/10.1039/c5nj02429c
State	Published - 1 Feb 2016

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@article{af3780a110994ab4b2eaae9268e14a96,

title = "In vitro antiproliferative activity of palladium(ii) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles",

abstract = "This work reports the synthesis and characterization of palladium(ii) complexes Pd(L1)2 (1), Pd(L2)2 (2), Pd(L3)2 (3) and Pd(L4)2 (4), where L1H: 1-naphthaldehyde thiosemicarbazone; L2H: 4-phenyl-(1-naphthaldehyde)thiosemicarbazone; L3H: (2-hydroxy-1-naphthaldehyde)thiosemicarbazone; L4H: 4-phenyl-1-(2-hydroxy-1-naphthaldehyde)thiosemicarbazone. All four complexes show in vitro antiproliferative activity against the following human tumor cell lines: H460, DU145, MCF-7, M14, HT-29, K562, and HuTu 80. In particular Pd(L1)2 has the most potent activity for all the studied cell lines (IC50 ∼ 1 μM), with the exception of H460. Pd(L2)2 is a promising candidate as a pharmacological agent, since it presents a significant activity and is more innocuous than cisplatin against mouse fibroblast normal cells, 3T3. Pd(L4)2 is the complex which exhibits the lowest activity against the same cell line (IC50 ∼ 11 μM), being ten times lower than that of Pd(L1)2. These complexes were used to functionalize chitosan coated superparamagnetic magnetite nanoparticles with a metallic core of 11-13 nm, and the activity of these functionalized nanoparticles (NPs) against diverse human tumor cell lines was also tested. The nanoparticles functionalized with Pd(L1)2, Pd(L3)2 and Pd(L4)2 show antiproliferative activity against DU-145, while those with Pd(L2)2, Pd(L3)2 and Pd(L4)2 against HuTu80.",

author = "Wilfredo Hern{\'a}ndez and Vaisberg, \{Abraham J.\} and Mabel Tobar and Melisa {\'A}lvarez and Jorge Manzur and Yuri Echevarr{\'i}a and Evgenia Spodine",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2016.",

year = "2016",

month = feb,

day = "1",

doi = "10.1039/c5nj02429c",

language = "Ingl{\'e}s",

volume = "40",

pages = "1853--1860",

journal = "New Journal of Chemistry",

issn = "1144-0546",

number = "2",

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TY - JOUR

T1 - In vitro antiproliferative activity of palladium(ii) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

AU - Hernández, Wilfredo

AU - Vaisberg, Abraham J.

AU - Tobar, Mabel

AU - Álvarez, Melisa

AU - Manzur, Jorge

AU - Echevarría, Yuri

AU - Spodine, Evgenia

PY - 2016/2/1

Y1 - 2016/2/1

N2 - This work reports the synthesis and characterization of palladium(ii) complexes Pd(L1)2 (1), Pd(L2)2 (2), Pd(L3)2 (3) and Pd(L4)2 (4), where L1H: 1-naphthaldehyde thiosemicarbazone; L2H: 4-phenyl-(1-naphthaldehyde)thiosemicarbazone; L3H: (2-hydroxy-1-naphthaldehyde)thiosemicarbazone; L4H: 4-phenyl-1-(2-hydroxy-1-naphthaldehyde)thiosemicarbazone. All four complexes show in vitro antiproliferative activity against the following human tumor cell lines: H460, DU145, MCF-7, M14, HT-29, K562, and HuTu 80. In particular Pd(L1)2 has the most potent activity for all the studied cell lines (IC50 ∼ 1 μM), with the exception of H460. Pd(L2)2 is a promising candidate as a pharmacological agent, since it presents a significant activity and is more innocuous than cisplatin against mouse fibroblast normal cells, 3T3. Pd(L4)2 is the complex which exhibits the lowest activity against the same cell line (IC50 ∼ 11 μM), being ten times lower than that of Pd(L1)2. These complexes were used to functionalize chitosan coated superparamagnetic magnetite nanoparticles with a metallic core of 11-13 nm, and the activity of these functionalized nanoparticles (NPs) against diverse human tumor cell lines was also tested. The nanoparticles functionalized with Pd(L1)2, Pd(L3)2 and Pd(L4)2 show antiproliferative activity against DU-145, while those with Pd(L2)2, Pd(L3)2 and Pd(L4)2 against HuTu80.

AB - This work reports the synthesis and characterization of palladium(ii) complexes Pd(L1)2 (1), Pd(L2)2 (2), Pd(L3)2 (3) and Pd(L4)2 (4), where L1H: 1-naphthaldehyde thiosemicarbazone; L2H: 4-phenyl-(1-naphthaldehyde)thiosemicarbazone; L3H: (2-hydroxy-1-naphthaldehyde)thiosemicarbazone; L4H: 4-phenyl-1-(2-hydroxy-1-naphthaldehyde)thiosemicarbazone. All four complexes show in vitro antiproliferative activity against the following human tumor cell lines: H460, DU145, MCF-7, M14, HT-29, K562, and HuTu 80. In particular Pd(L1)2 has the most potent activity for all the studied cell lines (IC50 ∼ 1 μM), with the exception of H460. Pd(L2)2 is a promising candidate as a pharmacological agent, since it presents a significant activity and is more innocuous than cisplatin against mouse fibroblast normal cells, 3T3. Pd(L4)2 is the complex which exhibits the lowest activity against the same cell line (IC50 ∼ 11 μM), being ten times lower than that of Pd(L1)2. These complexes were used to functionalize chitosan coated superparamagnetic magnetite nanoparticles with a metallic core of 11-13 nm, and the activity of these functionalized nanoparticles (NPs) against diverse human tumor cell lines was also tested. The nanoparticles functionalized with Pd(L1)2, Pd(L3)2 and Pd(L4)2 show antiproliferative activity against DU-145, while those with Pd(L2)2, Pd(L3)2 and Pd(L4)2 against HuTu80.

UR - https://www.scopus.com/pages/publications/84957899520

U2 - 10.1039/c5nj02429c

DO - 10.1039/c5nj02429c

M3 - Artículo

AN - SCOPUS:84957899520

SN - 1144-0546

VL - 40

SP - 1853

EP - 1860

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 2

ER -

In vitro antiproliferative activity of palladium(ii) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

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