In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

Gustavo Moura-Letts; Leon F. Villegas; Ana Marçalo; Abraham J. Vaisberg; Gerald B. Hammond

doi:10.1021/np0601152

In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

Gustavo Moura-Letts
, Leon F. Villegas
, Ana Marçalo
, Abraham J. Vaisberg
, Gerald B. Hammond

School of Science and Engineering

University of Louisville
Universidad Peruana Cayetano Heredia

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.

Original language	English
Pages (from-to)	978-979
Number of pages	2
Journal	Journal of Natural Products
Volume	69
Issue number	6
DOIs	https://doi.org/10.1021/np0601152
State	Published - Jun 2006

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title = "In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa",

abstract = "Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9\% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.",

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AU - Moura-Letts, Gustavo

AU - Villegas, Leon F.

AU - Marçalo, Ana

AU - Vaisberg, Abraham J.

AU - Hammond, Gerald B.

PY - 2006/6

Y1 - 2006/6

N2 - Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.

AB - Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.

UR - https://www.scopus.com/pages/publications/33746580850

U2 - 10.1021/np0601152

DO - 10.1021/np0601152

M3 - Artículo

C2 - 16792424

AN - SCOPUS:33746580850

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 6

ER -

In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

Abstract

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