Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

José C. Aponte; Abraham J. Vaisberg; Rosario Rojas; Luz Caviedes; Walter H. Lewis; Gerardo Lamas; César Sarasara; Robert H. Gilman; Gerald B. Hammond

doi:10.1021/np070560c

Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

José C. Aponte
, Abraham J. Vaisberg
, Rosario Rojas
, Luz Caviedes
, Walter H. Lewis
, Gerardo Lamas
, César Sarasara
, Robert H. Gilman
, Gerald B. Hammond

School of Science and Engineering

University of Louisville
Universidad Peruana Cayetano Heredia
Washington University in St. Louis
Museo de Historia Natural, Lima
Confederacion de Nacionalidades Amazónicas Del Perú
Johns Hopkins Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

Original language	English
Pages (from-to)	102-105
Number of pages	4
Journal	Journal of Natural Products
Volume	71
Issue number	1
DOIs	https://doi.org/10.1021/np070560c
State	Published - Jan 2008

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SDG 3 Good Health and Well-being

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10.1021/np070560c

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title = "Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants",

abstract = "The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.",

author = "Aponte, \{Jos{\'e} C.\} and Vaisberg, \{Abraham J.\} and Rosario Rojas and Luz Caviedes and Lewis, \{Walter H.\} and Gerardo Lamas and C{\'e}sar Sarasara and Gilman, \{Robert H.\} and Hammond, \{Gerald B.\}",

year = "2008",

month = jan,

doi = "10.1021/np070560c",

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volume = "71",

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T1 - Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

AU - Aponte, José C.

AU - Vaisberg, Abraham J.

AU - Rojas, Rosario

AU - Caviedes, Luz

AU - Lewis, Walter H.

AU - Lamas, Gerardo

AU - Sarasara, César

AU - Gilman, Robert H.

AU - Hammond, Gerald B.

PY - 2008/1

Y1 - 2008/1

N2 - The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

AB - The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

UR - https://www.scopus.com/pages/publications/39049164271

U2 - 10.1021/np070560c

DO - 10.1021/np070560c

M3 - Artículo

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AN - SCOPUS:39049164271

SN - 0163-3864

VL - 71

SP - 102

EP - 105

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 1

ER -

Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

Abstract

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