Latent tuberculosis infection and non-infectious co-morbidities: Diabetes mellitus type 2, chronic kidney disease and rheumatoid arthritis

Cesar Ugarte-Gil; Rodrigo M. Carrillo-Larco; Daniela E. Kirwan

doi:10.1016/j.ijid.2019.02.018

Latent tuberculosis infection and non-infectious co-morbidities: Diabetes mellitus type 2, chronic kidney disease and rheumatoid arthritis

Cesar Ugarte-Gil
, Rodrigo M. Carrillo-Larco
, Daniela E. Kirwan

School of Medicine

London School of Hygiene and Tropical Medicine
Johns Hopkins Bloomberg School of Public Health
Imperial College London
Universidad Peruana Cayetano Heredia
St George's University of London

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable diseases that are relevant because of their associated morbidity, mortality and disability are type 2 diabetes mellitus, chronic kidney disease and rheumatoid arthritis. There is some evidence that patients with these conditions are at increased risk of acquiring latent tuberculosis infection (LTBI) and of this progressing to active disease. Unfortunately, evidence on accurate testing and effective prophylactic treatment in these populations is lacking. This review discusses current evidence and recommendations for management of LTBI in these patients.

Original language	English
Pages (from-to)	S29-S31
Journal	International Journal of Infectious Diseases
Volume	80
DOIs	https://doi.org/10.1016/j.ijid.2019.02.018
State	Published - Mar 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chronic kidney disease and Rheumatoid arthritis
Diabetes mellitus type 2
Tuberculosis

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10.1016/j.ijid.2019.02.018

Cite this

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title = "Latent tuberculosis infection and non-infectious co-morbidities: Diabetes mellitus type 2, chronic kidney disease and rheumatoid arthritis",

abstract = "The prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable diseases that are relevant because of their associated morbidity, mortality and disability are type 2 diabetes mellitus, chronic kidney disease and rheumatoid arthritis. There is some evidence that patients with these conditions are at increased risk of acquiring latent tuberculosis infection (LTBI) and of this progressing to active disease. Unfortunately, evidence on accurate testing and effective prophylactic treatment in these populations is lacking. This review discusses current evidence and recommendations for management of LTBI in these patients.",

keywords = "Chronic kidney disease and Rheumatoid arthritis, Diabetes mellitus type 2, Tuberculosis",

author = "Cesar Ugarte-Gil and Carrillo-Larco, \{Rodrigo M.\} and Kirwan, \{Daniela E.\}",

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year = "2019",

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doi = "10.1016/j.ijid.2019.02.018",

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T2 - Diabetes mellitus type 2, chronic kidney disease and rheumatoid arthritis

AU - Ugarte-Gil, Cesar

AU - Carrillo-Larco, Rodrigo M.

AU - Kirwan, Daniela E.

PY - 2019/3

Y1 - 2019/3

N2 - The prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable diseases that are relevant because of their associated morbidity, mortality and disability are type 2 diabetes mellitus, chronic kidney disease and rheumatoid arthritis. There is some evidence that patients with these conditions are at increased risk of acquiring latent tuberculosis infection (LTBI) and of this progressing to active disease. Unfortunately, evidence on accurate testing and effective prophylactic treatment in these populations is lacking. This review discusses current evidence and recommendations for management of LTBI in these patients.

AB - The prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable diseases that are relevant because of their associated morbidity, mortality and disability are type 2 diabetes mellitus, chronic kidney disease and rheumatoid arthritis. There is some evidence that patients with these conditions are at increased risk of acquiring latent tuberculosis infection (LTBI) and of this progressing to active disease. Unfortunately, evidence on accurate testing and effective prophylactic treatment in these populations is lacking. This review discusses current evidence and recommendations for management of LTBI in these patients.

KW - Chronic kidney disease and Rheumatoid arthritis

KW - Diabetes mellitus type 2

KW - Tuberculosis

UR - https://www.scopus.com/pages/publications/85062173537

U2 - 10.1016/j.ijid.2019.02.018

DO - 10.1016/j.ijid.2019.02.018

M3 - Artículo

C2 - 30802622

AN - SCOPUS:85062173537

SN - 1201-9712

VL - 80

SP - S29-S31

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Latent tuberculosis infection and non-infectious co-morbidities: Diabetes mellitus type 2, chronic kidney disease and rheumatoid arthritis

Abstract

UN SDGs

Keywords

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