Meningoencephalitis Due to Free-Living Amoebas in the Tropics

Carlos Seas; Pedro Legua

doi:10.1007/s40475-022-00254-9

Meningoencephalitis Due to Free-Living Amoebas in the Tropics

Carlos Seas
, Pedro Legua

School of Medicine

Hospital Nacional Cayetano Heredia
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Purpose of Review: To asses recent advances in our understanding of the epidemiology, clinical presentation, diagnosis, and treatment of infections caused by free-living amoebas Recent Findings: The burden of disease by free-living amoebas is underestimated; global warming could increase incidence in future years. Early recognition of clinical syndromes may allow for prompt initiation of therapy and better disease outcome. Molecular tests allow for rapid identification of the amoeba. Treatment is based on successful clinical outcomes reported using repurposed drugs. The optimal regimen for each of the clinical syndromes is unknown. Summary: As global warming increases, clinicians will be challenged to diagnose and treat infections by free-living amoebas. Therefore, awareness of clinical syndromes, diagnostic tools, and therapeutic interventions is crucial.

Original language	English
Pages (from-to)	8-14
Number of pages	7
Journal	Current Tropical Medicine Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1007/s40475-022-00254-9
State	Published - Mar 2022

Keywords

Acanthamoeba
Balamuthia mandrillaris
Free-living amoebas
Granulomatous amebic encephalitis
Naegleria fowleri
Primary amebic meningoencephalitis

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10.1007/s40475-022-00254-9

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title = "Meningoencephalitis Due to Free-Living Amoebas in the Tropics",

abstract = "Purpose of Review: To asses recent advances in our understanding of the epidemiology, clinical presentation, diagnosis, and treatment of infections caused by free-living amoebas Recent Findings: The burden of disease by free-living amoebas is underestimated; global warming could increase incidence in future years. Early recognition of clinical syndromes may allow for prompt initiation of therapy and better disease outcome. Molecular tests allow for rapid identification of the amoeba. Treatment is based on successful clinical outcomes reported using repurposed drugs. The optimal regimen for each of the clinical syndromes is unknown. Summary: As global warming increases, clinicians will be challenged to diagnose and treat infections by free-living amoebas. Therefore, awareness of clinical syndromes, diagnostic tools, and therapeutic interventions is crucial.",

keywords = "Acanthamoeba, Balamuthia mandrillaris, Free-living amoebas, Granulomatous amebic encephalitis, Naegleria fowleri, Primary amebic meningoencephalitis",

author = "Carlos Seas and Pedro Legua",

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doi = "10.1007/s40475-022-00254-9",

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T1 - Meningoencephalitis Due to Free-Living Amoebas in the Tropics

AU - Seas, Carlos

AU - Legua, Pedro

PY - 2022/3

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N2 - Purpose of Review: To asses recent advances in our understanding of the epidemiology, clinical presentation, diagnosis, and treatment of infections caused by free-living amoebas Recent Findings: The burden of disease by free-living amoebas is underestimated; global warming could increase incidence in future years. Early recognition of clinical syndromes may allow for prompt initiation of therapy and better disease outcome. Molecular tests allow for rapid identification of the amoeba. Treatment is based on successful clinical outcomes reported using repurposed drugs. The optimal regimen for each of the clinical syndromes is unknown. Summary: As global warming increases, clinicians will be challenged to diagnose and treat infections by free-living amoebas. Therefore, awareness of clinical syndromes, diagnostic tools, and therapeutic interventions is crucial.

AB - Purpose of Review: To asses recent advances in our understanding of the epidemiology, clinical presentation, diagnosis, and treatment of infections caused by free-living amoebas Recent Findings: The burden of disease by free-living amoebas is underestimated; global warming could increase incidence in future years. Early recognition of clinical syndromes may allow for prompt initiation of therapy and better disease outcome. Molecular tests allow for rapid identification of the amoeba. Treatment is based on successful clinical outcomes reported using repurposed drugs. The optimal regimen for each of the clinical syndromes is unknown. Summary: As global warming increases, clinicians will be challenged to diagnose and treat infections by free-living amoebas. Therefore, awareness of clinical syndromes, diagnostic tools, and therapeutic interventions is crucial.

KW - Acanthamoeba

KW - Balamuthia mandrillaris

KW - Free-living amoebas

KW - Granulomatous amebic encephalitis

KW - Naegleria fowleri

KW - Primary amebic meningoencephalitis

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DO - 10.1007/s40475-022-00254-9

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JO - Current Tropical Medicine Reports

JF - Current Tropical Medicine Reports

IS - 1

ER -

Meningoencephalitis Due to Free-Living Amoebas in the Tropics

Abstract

Keywords

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