Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Lymph Node TB Working Group, Peru

doi:10.1128/JCM.02227-15

Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Lymph Node TB Working Group, Peru

School of Medicine

St George's Hospital
Imperial College London
Johns Hopkins University
Universidad Peruana Cayetano Heredia
Barts Health NHS Trust
Hospital Nacional Dos de Mayo
Univ. Nacional Mayor de San Marcos
San Martin de Porres University
Hospital Nacional Daniel Alcides Carrion
Arzobispo Loayza Hospital
Wellcome Trust
London School of Hygiene and Tropical Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

Original language	English
Pages (from-to)	185-189
Number of pages	5
Journal	Journal of Clinical Microbiology
Volume	54
Issue number	1
DOIs	https://doi.org/10.1128/JCM.02227-15
State	Published - Jan 2016

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10.1128/JCM.02227-15

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title = "Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance",

abstract = "In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4\%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4\%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.",

author = "\{Lymph Node TB Working Group, Peru\} and Kirwan, \{Daniela E.\} and Cesar Ugarte-Gil and Gilman, \{Robert H.\} and Hasan Rizvi and Eduardo Ticona and Gonzalo Chavez and Cabrera, \{Jos{\'e} Luis\} and Matos, \{Eduardo D.\} and Evans, \{Carlton A.\} and Moore, \{David A.J.\} and Friedland, \{Jon S.\}",

year = "2016",

month = jan,

doi = "10.1128/JCM.02227-15",

language = "Ingl{\'e}s",

volume = "54",

pages = "185--189",

journal = "Journal of Clinical Microbiology",

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TY - JOUR

T1 - Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

AU - Lymph Node TB Working Group, Peru

AU - Kirwan, Daniela E.

AU - Ugarte-Gil, Cesar

AU - Gilman, Robert H.

AU - Rizvi, Hasan

AU - Ticona, Eduardo

AU - Chavez, Gonzalo

AU - Cabrera, José Luis

AU - Matos, Eduardo D.

AU - Evans, Carlton A.

AU - Moore, David A.J.

AU - Friedland, Jon S.

PY - 2016/1

Y1 - 2016/1

N2 - In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

AB - In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

UR - https://www.scopus.com/pages/publications/84954316860

U2 - 10.1128/JCM.02227-15

DO - 10.1128/JCM.02227-15

M3 - Artículo

C2 - 26511739

AN - SCOPUS:84954316860

SN - 0095-1137

VL - 54

SP - 185

EP - 189

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 1

ER -

Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Abstract

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