Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ—Global Registry for Emerging Fungal Infections

Jon Salmanton-García; Philipp Koehler; Anupma Kindo; Iker Falces-Romero; Julio García-Rodríguez; Zdeněk Ráčil; Sharon C.A. Chen; Nikolai Klimko; Guillaume Desoubeaux; George R. Thompson; Miguel Ángel Benítez-Peñuela; José Yesid Rodríguez; Donald C. Sheppard; Martin Hoenigl; Yohann Le Govic; Hamid Badali; John W. Baddley; Jagdish Chander; Paul R. Ingram; Diana L. Pakstis; Sibylle C. Mellinghoff; Serkan Atıcı; Simone Cesaro; Arunaloke Chakrabarti; Damien Dupont; Gloria M. González; Lóránt Hatvani; Raoul Herbrecht; Galina Klyasova; Cornelia Lass-Flörl; Mihai Mareș; Kathleen Mullane; Donald C. Vinh; Hilmar Wisplinghoff; Michaela Lackner; Oliver A. Cornely; Danila Seidel; Barbara D. Alexander; María Almagro-Molto; Eduardo Álvarez-Duarte; Martha Avilés-Robles; Aleksandra Barać; Vanda Chrenková; Patricia Cornejo-Juárez; Nicole Desbois-Nogard; Mario Fernández-Ruiz; Luis Figueira; Jesús García-Martínez; Sandra Gräber; Barbara Graf; Georg Haerter; Shariq Haider; Pamela Hartman; Melina Heinemann; Aamer Ikram; Frédéric Janvier; Jeffrey D. Jenks; Carol Kauffman; Robert Krause; Me Linh Luong; Shruti Malik; Vincent Marconi; Rodrigo Martino; Sanjay R. Mehta; Lisa Meintker; Andrea Mocná; Michele I. Morris; Alessandro C. Pasqualotto; Atul Patel; Olaf Penack; Nicolas Pichon; Mathias W. Pletz; Carlos Seas; Uluhan Sili; Monica Slavin; Kenji Uno; Jose A. Vazquez; Thomas Weber; Barbora Weinbergerova; Deniz Yilmaz-Karapinar; Seda Yilmaz-Semerci; Jin Yu

doi:10.1016/j.jinf.2020.08.015

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope^Ⓡ—Global Registry for Emerging Fungal Infections

Jon Salmanton-García
, Philipp Koehler
, Anupma Kindo
, Iker Falces-Romero
, Julio García-Rodríguez
, Zdeněk Ráčil
, Sharon C.A. Chen
, Nikolai Klimko
, Guillaume Desoubeaux
, George R. Thompson
, Miguel Ángel Benítez-Peñuela
, José Yesid Rodríguez
, Donald C. Sheppard
, Martin Hoenigl
, Yohann Le Govic
, Hamid Badali
, John W. Baddley
, Jagdish Chander
, Paul R. Ingram
, Diana L. Pakstis

Sibylle C. Mellinghoff, Serkan Atıcı, Simone Cesaro, Arunaloke Chakrabarti, Damien Dupont, Gloria M. González, Lóránt Hatvani, Raoul Herbrecht, Galina Klyasova, Cornelia Lass-Flörl, Mihai Mareș, Kathleen Mullane, Donald C. Vinh, Hilmar Wisplinghoff, Michaela Lackner, Oliver A. Cornely, Danila Seidel, Barbara D. Alexander, María Almagro-Molto, Eduardo Álvarez-Duarte, Martha Avilés-Robles, Aleksandra Barać, Vanda Chrenková, Patricia Cornejo-Juárez, Nicole Desbois-Nogard, Mario Fernández-Ruiz, Luis Figueira, Jesús García-Martínez, Sandra Gräber, Barbara Graf, Georg Haerter, Shariq Haider, Pamela Hartman, Melina Heinemann, Aamer Ikram, Frédéric Janvier, Jeffrey D. Jenks, Carol Kauffman, Robert Krause, Me Linh Luong, Shruti Malik, Vincent Marconi, Rodrigo Martino, Sanjay R. Mehta, Lisa Meintker, Andrea Mocná, Michele I. Morris, Alessandro C. Pasqualotto, Atul Patel, Olaf Penack, Nicolas Pichon, Mathias W. Pletz, Carlos Seas, Uluhan Sili, Monica Slavin, Kenji Uno, Jose A. Vazquez, Thomas Weber, Barbora Weinbergerova, Deniz Yilmaz-Karapinar, Seda Yilmaz-Semerci, Jin Yu

School of Medicine

University of Cologne
University of Cologne
Sri Ramachandra Institute for Higher Education and Research
University Hospital La Paz
Masaryk University
University Hospital Brno
Institute of Hematology and Blood Transfusion
Westmead Hospital
University of Sydney
Mechnikov North-Western State Medical University
CHU de Tours
Université de Tours
University of California Davis Medical Center
Médicos Clinic LTDA
Research Institute - McGill University Health Centre
University of California la Jolla
Department of Medicine
Medical University of Graz
University Hospital Center
Mazandaran University of Medical Sciences
University of Alabama at Birmingham
US Department of Veterans Affairs
University of Maryland School of Medicine
Government Medical College and Hospital
Royal Perth Hospital
University of Western Australia
University of Pittsburgh School of Medicine
Okan University School of Medicine
Azienda Ospedaliera Universitaria Integrata Verona
Post Graduate Institute of Medical Education and Research
Hospices Civils de Lyon
Université Claude Bernard Lyon 1
Universidad Autonóma de Nuevo León
MTA-SZTE “Lendület” Mycobiome Research Group
University of Szeged Faculty of Science and Informatics
Hôpitaux Universitaires de Strasbourg and Université de Strasbourg
National Research Center for Hematology
Medical University Innsbruck
Ion Ionescu de la Brad University
University of Chicago
Wisplinghoff Laboratories
Witten/Herdecke University
German Centre for Infection Research (DZIF)
University of Cologne

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScope^Ⓡ registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScope^Ⓡ. Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens.

Original language	English
Pages (from-to)	802-815
Number of pages	14
Journal	Journal of Infection
Volume	81
Issue number	5
DOIs	https://doi.org/10.1016/j.jinf.2020.08.015
State	Published - Nov 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Invasive fungal infections
Mold
Rare
Registry
Yeast

Access to Document

10.1016/j.jinf.2020.08.015

Cite this

Salmanton-García, J., Koehler, P., Kindo, A., Falces-Romero, I., García-Rodríguez, J., Ráčil, Z., Chen, S. C. A., Klimko, N., Desoubeaux, G., Thompson, G. R., Benítez-Peñuela, M. Á., Rodríguez, J. Y., Sheppard, D. C., Hoenigl, M., Le Govic, Y., Badali, H., Baddley, J. W., Chander, J., Ingram, P. R., ... Yu, J. (2020). Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope^Ⓡ—Global Registry for Emerging Fungal Infections. Journal of Infection, 81(5), 802-815. https://doi.org/10.1016/j.jinf.2020.08.015

@article{88a24c02b02042e4b941a2d58d305607,

title = "Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ—Global Registry for Emerging Fungal Infections",

abstract = "Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScopeⓇ registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScopeⓇ. Dematiaceae (35.5\%), Hypocreales (23.1\%), Mucorales (11.8\%), and Saccharomycetales (11.3\%) caused most IFI. Most patients had an underlying malignancy (38.7\%) with acute leukemia accounting for 50\% of cancers. Dissemination was observed in 26.9\% of the patients. Complete or partial clinical response rate was 68.3\%, being highest in Eurotiales (82.4\%) and in Agaricales (80.0\%). Overall mortality rate was 29.3\%, ranging from 11.8\% in Eurotiales to 50.0\% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens.",

keywords = "Invasive fungal infections, Mold, Rare, Registry, Yeast",

author = "Jon Salmanton-Garc{\'i}a and Philipp Koehler and Anupma Kindo and Iker Falces-Romero and Julio Garc{\'i}a-Rodr{\'i}guez and Zden{\v e}k R{\'a}{\v c}il and Chen, \{Sharon C.A.\} and Nikolai Klimko and Guillaume Desoubeaux and Thompson, \{George R.\} and Ben{\'i}tez-Pe{\~n}uela, \{Miguel {\'A}ngel\} and Rodr{\'i}guez, \{Jos{\'e} Yesid\} and Sheppard, \{Donald C.\} and Martin Hoenigl and \{Le Govic\}, Yohann and Hamid Badali and Baddley, \{John W.\} and Jagdish Chander and Ingram, \{Paul R.\} and Pakstis, \{Diana L.\} and Mellinghoff, \{Sibylle C.\} and Serkan Atıcı and Simone Cesaro and Arunaloke Chakrabarti and Damien Dupont and Gonz{\'a}lez, \{Gloria M.\} and L{\'o}r{\'a}nt Hatvani and Raoul Herbrecht and Galina Klyasova and Cornelia Lass-Fl{\"o}rl and Mihai Mareș and Kathleen Mullane and Vinh, \{Donald C.\} and Hilmar Wisplinghoff and Michaela Lackner and Cornely, \{Oliver A.\} and Danila Seidel and Alexander, \{Barbara D.\} and Mar{\'i}a Almagro-Molto and Eduardo {\'A}lvarez-Duarte and Martha Avil{\'e}s-Robles and Aleksandra Bara{\'c} and Vanda Chrenkov{\'a} and Patricia Cornejo-Ju{\'a}rez and Nicole Desbois-Nogard and Mario Fern{\'a}ndez-Ruiz and Luis Figueira and Jes{\'u}s Garc{\'i}a-Mart{\'i}nez and Sandra Gr{\"a}ber and Barbara Graf and Georg Haerter and Shariq Haider and Pamela Hartman and Melina Heinemann and Aamer Ikram and Fr{\'e}d{\'e}ric Janvier and Jenks, \{Jeffrey D.\} and Carol Kauffman and Robert Krause and Luong, \{Me Linh\} and Shruti Malik and Vincent Marconi and Rodrigo Martino and Mehta, \{Sanjay R.\} and Lisa Meintker and Andrea Mocn{\'a} and Morris, \{Michele I.\} and Pasqualotto, \{Alessandro C.\} and Atul Patel and Olaf Penack and Nicolas Pichon and Pletz, \{Mathias W.\} and Carlos Seas and Uluhan Sili and Monica Slavin and Kenji Uno and Vazquez, \{Jose A.\} and Thomas Weber and Barbora Weinbergerova and Deniz Yilmaz-Karapinar and Seda Yilmaz-Semerci and Jin Yu",

note = "Publisher Copyright: {\textcopyright} 2020 The British Infection Association",

year = "2020",

month = nov,

doi = "10.1016/j.jinf.2020.08.015",

language = "Ingl{\'e}s",

volume = "81",

pages = "802--815",

journal = "Journal of Infection",

issn = "0163-4453",

number = "5",

}

Salmanton-García, J, Koehler, P, Kindo, A, Falces-Romero, I, García-Rodríguez, J, Ráčil, Z, Chen, SCA, Klimko, N, Desoubeaux, G, Thompson, GR, Benítez-Peñuela, MÁ, Rodríguez, JY, Sheppard, DC, Hoenigl, M, Le Govic, Y, Badali, H, Baddley, JW, Chander, J, Ingram, PR, Pakstis, DL, Mellinghoff, SC, Atıcı, S, Cesaro, S, Chakrabarti, A, Dupont, D, González, GM, Hatvani, L, Herbrecht, R, Klyasova, G, Lass-Flörl, C, Mareș, M, Mullane, K, Vinh, DC, Wisplinghoff, H, Lackner, M, Cornely, OA, Seidel, D, Alexander, BD, Almagro-Molto, M, Álvarez-Duarte, E, Avilés-Robles, M, Barać, A, Chrenková, V, Cornejo-Juárez, P, Desbois-Nogard, N, Fernández-Ruiz, M, Figueira, L, García-Martínez, J, Gräber, S, Graf, B, Haerter, G, Haider, S, Hartman, P, Heinemann, M, Ikram, A, Janvier, F, Jenks, JD, Kauffman, C, Krause, R, Luong, ML, Malik, S, Marconi, V, Martino, R, Mehta, SR, Meintker, L, Mocná, A, Morris, MI, Pasqualotto, AC, Patel, A, Penack, O, Pichon, N, Pletz, MW, Seas, C, Sili, U, Slavin, M, Uno, K, Vazquez, JA, Weber, T, Weinbergerova, B, Yilmaz-Karapinar, D, Yilmaz-Semerci, S & Yu, J 2020, 'Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope^Ⓡ—Global Registry for Emerging Fungal Infections', Journal of Infection, vol. 81, no. 5, pp. 802-815. https://doi.org/10.1016/j.jinf.2020.08.015

TY - JOUR

T1 - Needles in a haystack

T2 - Extremely rare invasive fungal infections reported in FungiScopeⓇ—Global Registry for Emerging Fungal Infections

AU - Salmanton-García, Jon

AU - Koehler, Philipp

AU - Kindo, Anupma

AU - Falces-Romero, Iker

AU - García-Rodríguez, Julio

AU - Ráčil, Zdeněk

AU - Chen, Sharon C.A.

AU - Klimko, Nikolai

AU - Desoubeaux, Guillaume

AU - Thompson, George R.

AU - Benítez-Peñuela, Miguel Ángel

AU - Rodríguez, José Yesid

AU - Sheppard, Donald C.

AU - Hoenigl, Martin

AU - Le Govic, Yohann

AU - Badali, Hamid

AU - Baddley, John W.

AU - Chander, Jagdish

AU - Ingram, Paul R.

AU - Pakstis, Diana L.

AU - Mellinghoff, Sibylle C.

AU - Atıcı, Serkan

AU - Cesaro, Simone

AU - Chakrabarti, Arunaloke

AU - Dupont, Damien

AU - González, Gloria M.

AU - Hatvani, Lóránt

AU - Herbrecht, Raoul

AU - Klyasova, Galina

AU - Lass-Flörl, Cornelia

AU - Mareș, Mihai

AU - Mullane, Kathleen

AU - Vinh, Donald C.

AU - Wisplinghoff, Hilmar

AU - Lackner, Michaela

AU - Cornely, Oliver A.

AU - Seidel, Danila

AU - Alexander, Barbara D.

AU - Almagro-Molto, María

AU - Álvarez-Duarte, Eduardo

AU - Avilés-Robles, Martha

AU - Barać, Aleksandra

AU - Chrenková, Vanda

AU - Cornejo-Juárez, Patricia

AU - Desbois-Nogard, Nicole

AU - Fernández-Ruiz, Mario

AU - Figueira, Luis

AU - García-Martínez, Jesús

AU - Gräber, Sandra

AU - Graf, Barbara

AU - Haerter, Georg

AU - Haider, Shariq

AU - Hartman, Pamela

AU - Heinemann, Melina

AU - Ikram, Aamer

AU - Janvier, Frédéric

AU - Jenks, Jeffrey D.

AU - Kauffman, Carol

AU - Krause, Robert

AU - Luong, Me Linh

AU - Malik, Shruti

AU - Marconi, Vincent

AU - Martino, Rodrigo

AU - Mehta, Sanjay R.

AU - Meintker, Lisa

AU - Mocná, Andrea

AU - Morris, Michele I.

AU - Pasqualotto, Alessandro C.

AU - Patel, Atul

AU - Penack, Olaf

AU - Pichon, Nicolas

AU - Pletz, Mathias W.

AU - Seas, Carlos

AU - Sili, Uluhan

AU - Slavin, Monica

AU - Uno, Kenji

AU - Vazquez, Jose A.

AU - Weber, Thomas

AU - Weinbergerova, Barbora

AU - Yilmaz-Karapinar, Deniz

AU - Yilmaz-Semerci, Seda

AU - Yu, Jin

PY - 2020/11

Y1 - 2020/11

N2 - Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScopeⓇ registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScopeⓇ. Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens.

AB - Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScopeⓇ registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScopeⓇ. Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens.

KW - Invasive fungal infections

KW - Mold

KW - Rare

KW - Registry

KW - Yeast

UR - https://www.scopus.com/pages/publications/85091481893

U2 - 10.1016/j.jinf.2020.08.015

DO - 10.1016/j.jinf.2020.08.015

M3 - Artículo

C2 - 32798532

AN - SCOPUS:85091481893

SN - 0163-4453

VL - 81

SP - 802

EP - 815

JO - Journal of Infection

JF - Journal of Infection

IS - 5

ER -