Neonatal tetanus in Peru: Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test

L. Vernacchio; G. Madico; M. Verastegui; F. Diaz; T. S. Collins; R. H. Gilman

doi:10.2105/AJPH.83.12.1754

Neonatal tetanus in Peru: Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test

L. Vernacchio
, G. Madico
, M. Verastegui
, F. Diaz
, T. S. Collins
, R. H. Gilman

Johns Hopkins Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We used a modified enzyme-linked immunosorbent assay (ELISA) to investigate tetanus immunity in 232 pregnant Peruvian women. One hundred forty-two (61.2%) had protective antitoxin titers (≥0.01 IU/mL). Protective titers correlated positively with the number of toxoid doses reported during the current pregnancy. A majority of women reporting no toxoid doses during the current pregnancy had at least one prenatal health care visit. We evaluated a toxoid skin test in 44 of the subjects, but it correlated poorly with the ELISA. The modified ELISA is a useful in vitro method for studying tetanus immunity in the developing world.

Original language	English
Pages (from-to)	1754-1756
Number of pages	3
Journal	American Journal of Public Health
Volume	83
Issue number	12
DOIs	https://doi.org/10.2105/AJPH.83.12.1754
State	Published - 1993
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.2105/AJPH.83.12.1754

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title = "Neonatal tetanus in Peru: Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test",

abstract = "We used a modified enzyme-linked immunosorbent assay (ELISA) to investigate tetanus immunity in 232 pregnant Peruvian women. One hundred forty-two (61.2\%) had protective antitoxin titers (≥0.01 IU/mL). Protective titers correlated positively with the number of toxoid doses reported during the current pregnancy. A majority of women reporting no toxoid doses during the current pregnancy had at least one prenatal health care visit. We evaluated a toxoid skin test in 44 of the subjects, but it correlated poorly with the ELISA. The modified ELISA is a useful in vitro method for studying tetanus immunity in the developing world.",

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T1 - Neonatal tetanus in Peru

T2 - Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test

AU - Vernacchio, L.

AU - Madico, G.

AU - Verastegui, M.

AU - Diaz, F.

AU - Collins, T. S.

AU - Gilman, R. H.

PY - 1993

Y1 - 1993

N2 - We used a modified enzyme-linked immunosorbent assay (ELISA) to investigate tetanus immunity in 232 pregnant Peruvian women. One hundred forty-two (61.2%) had protective antitoxin titers (≥0.01 IU/mL). Protective titers correlated positively with the number of toxoid doses reported during the current pregnancy. A majority of women reporting no toxoid doses during the current pregnancy had at least one prenatal health care visit. We evaluated a toxoid skin test in 44 of the subjects, but it correlated poorly with the ELISA. The modified ELISA is a useful in vitro method for studying tetanus immunity in the developing world.

AB - We used a modified enzyme-linked immunosorbent assay (ELISA) to investigate tetanus immunity in 232 pregnant Peruvian women. One hundred forty-two (61.2%) had protective antitoxin titers (≥0.01 IU/mL). Protective titers correlated positively with the number of toxoid doses reported during the current pregnancy. A majority of women reporting no toxoid doses during the current pregnancy had at least one prenatal health care visit. We evaluated a toxoid skin test in 44 of the subjects, but it correlated poorly with the ELISA. The modified ELISA is a useful in vitro method for studying tetanus immunity in the developing world.

UR - https://www.scopus.com/pages/publications/0027132108

U2 - 10.2105/AJPH.83.12.1754

DO - 10.2105/AJPH.83.12.1754

M3 - Artículo

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AN - SCOPUS:0027132108

SN - 0090-0036

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SP - 1754

EP - 1756

JO - American Journal of Public Health

JF - American Journal of Public Health

IS - 12

ER -

Neonatal tetanus in Peru: Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test

Abstract

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