One-carbon metabolism disturbances in affective disorders. A preliminary report

Renato D. Alarcon; Lelland C. Tolbert; John A. Monti; Donna A. Morere; William G. Walter-Ryan; Beverly Kemp; John R. Smythies

doi:10.1016/0165-0327(85)90060-6

One-carbon metabolism disturbances in affective disorders. A preliminary report

Renato D. Alarcon
, Lelland C. Tolbert
, John A. Monti
, Donna A. Morere
, William G. Walter-Ryan
, Beverly Kemp
, John R. Smythies

UAB Department of Psychiatry and Behavioral Neurobiology
University of Alabama at Birmingham

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Methionine adenosyltransferase (MAT) activity (V_max) and the relative amount of phosphatidylcholine (% PC) were measured in erythrocytes of up to 30 DSM-III diagnosed manic, 17 unipolar depressed patients, and 28 normal controls. Manic subjects had significantly higher and depressed subjects significantly lower MAT V_max than normals. The relative amount of PC was in the low range for the depressives, and in the high range for the manics. Depressive patients present, in these tests, similar abnormalities to those seen previously in schizophrenic patients. Clinical and diagnostic implications of these findings are discussed.

Original language	English
Pages (from-to)	297-301
Number of pages	5
Journal	Journal of Affective Disorders
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/0165-0327(85)90060-6
State	Published - Nov 1985
Externally published	Yes

Keywords

Mania - Methionine-adenosyl-transferase - One carbon metabolism - Phosphatidylcholine - Unipolar depression

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10.1016/0165-0327(85)90060-6

Cite this

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title = "One-carbon metabolism disturbances in affective disorders. A preliminary report",

abstract = "Methionine adenosyltransferase (MAT) activity (Vmax) and the relative amount of phosphatidylcholine (\% PC) were measured in erythrocytes of up to 30 DSM-III diagnosed manic, 17 unipolar depressed patients, and 28 normal controls. Manic subjects had significantly higher and depressed subjects significantly lower MAT Vmax than normals. The relative amount of PC was in the low range for the depressives, and in the high range for the manics. Depressive patients present, in these tests, similar abnormalities to those seen previously in schizophrenic patients. Clinical and diagnostic implications of these findings are discussed.",

keywords = "Mania - Methionine-adenosyl-transferase - One carbon metabolism - Phosphatidylcholine - Unipolar depression",

author = "Alarcon, \{Renato D.\} and Tolbert, \{Lelland C.\} and Monti, \{John A.\} and Morere, \{Donna A.\} and Walter-Ryan, \{William G.\} and Beverly Kemp and Smythies, \{John R.\}",

year = "1985",

month = nov,

doi = "10.1016/0165-0327(85)90060-6",

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journal = "Journal of Affective Disorders",

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T1 - One-carbon metabolism disturbances in affective disorders. A preliminary report

AU - Alarcon, Renato D.

AU - Tolbert, Lelland C.

AU - Monti, John A.

AU - Morere, Donna A.

AU - Walter-Ryan, William G.

AU - Kemp, Beverly

AU - Smythies, John R.

PY - 1985/11

Y1 - 1985/11

N2 - Methionine adenosyltransferase (MAT) activity (Vmax) and the relative amount of phosphatidylcholine (% PC) were measured in erythrocytes of up to 30 DSM-III diagnosed manic, 17 unipolar depressed patients, and 28 normal controls. Manic subjects had significantly higher and depressed subjects significantly lower MAT Vmax than normals. The relative amount of PC was in the low range for the depressives, and in the high range for the manics. Depressive patients present, in these tests, similar abnormalities to those seen previously in schizophrenic patients. Clinical and diagnostic implications of these findings are discussed.

AB - Methionine adenosyltransferase (MAT) activity (Vmax) and the relative amount of phosphatidylcholine (% PC) were measured in erythrocytes of up to 30 DSM-III diagnosed manic, 17 unipolar depressed patients, and 28 normal controls. Manic subjects had significantly higher and depressed subjects significantly lower MAT Vmax than normals. The relative amount of PC was in the low range for the depressives, and in the high range for the manics. Depressive patients present, in these tests, similar abnormalities to those seen previously in schizophrenic patients. Clinical and diagnostic implications of these findings are discussed.

KW - Mania - Methionine-adenosyl-transferase - One carbon metabolism - Phosphatidylcholine - Unipolar depression

UR - https://www.scopus.com/pages/publications/0022385928

U2 - 10.1016/0165-0327(85)90060-6

DO - 10.1016/0165-0327(85)90060-6

M3 - Artículo

C2 - 2934462

AN - SCOPUS:0022385928

SN - 0165-0327

VL - 9

SP - 297

EP - 301

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 3

ER -

One-carbon metabolism disturbances in affective disorders. A preliminary report

Abstract

Keywords

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