Pharmacological effects of a Peruvian scorpion (Hadruroides lunatus) venom

A. Zavaleta; J. Navarro; R. Castro De La Mata

doi:10.1016/0041-0101(81)90090-8

Pharmacological effects of a Peruvian scorpion (Hadruroides lunatus) venom

A. Zavaleta
, J. Navarro
, R. Castro De La Mata

Universidad Peruana Cayetano Heredia

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Hadruroides lunatus venom has a low lethality in mice (ld₅₀, 68 mg/kg i.p.) and in dogs induces a fall in blood pressure which is prevented by an antihistaminic. The venom liberates acetylcholine and potentiates acetylcholine and serotonin actions in the rat ileum. It does not affect rat phrenic nerve-diaphragm nor toad rectus abdominis isolated preparations, but increases basal tone of the isolated atrium of the rat.

Original language	English
Pages (from-to)	906-909
Number of pages	4
Journal	Toxicon
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/0041-0101(81)90090-8
State	Published - 1981

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title = "Pharmacological effects of a Peruvian scorpion (Hadruroides lunatus) venom",

abstract = "Hadruroides lunatus venom has a low lethality in mice (ld50, 68 mg/kg i.p.) and in dogs induces a fall in blood pressure which is prevented by an antihistaminic. The venom liberates acetylcholine and potentiates acetylcholine and serotonin actions in the rat ileum. It does not affect rat phrenic nerve-diaphragm nor toad rectus abdominis isolated preparations, but increases basal tone of the isolated atrium of the rat.",

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AU - Zavaleta, A.

AU - Navarro, J.

AU - Castro De La Mata, R.

PY - 1981

Y1 - 1981

N2 - Hadruroides lunatus venom has a low lethality in mice (ld50, 68 mg/kg i.p.) and in dogs induces a fall in blood pressure which is prevented by an antihistaminic. The venom liberates acetylcholine and potentiates acetylcholine and serotonin actions in the rat ileum. It does not affect rat phrenic nerve-diaphragm nor toad rectus abdominis isolated preparations, but increases basal tone of the isolated atrium of the rat.

AB - Hadruroides lunatus venom has a low lethality in mice (ld50, 68 mg/kg i.p.) and in dogs induces a fall in blood pressure which is prevented by an antihistaminic. The venom liberates acetylcholine and potentiates acetylcholine and serotonin actions in the rat ileum. It does not affect rat phrenic nerve-diaphragm nor toad rectus abdominis isolated preparations, but increases basal tone of the isolated atrium of the rat.

UR - https://www.scopus.com/pages/publications/0019810788

U2 - 10.1016/0041-0101(81)90090-8

DO - 10.1016/0041-0101(81)90090-8

M3 - Artículo

C2 - 7336455

AN - SCOPUS:0019810788

SN - 0041-0101

VL - 19

SP - 906

EP - 909

JO - Toxicon

JF - Toxicon

IS - 6

ER -

Pharmacological effects of a Peruvian scorpion (Hadruroides lunatus) venom

Abstract

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