Physangulidines A, B, and C: Three new antiproliferative withanolides from Physalis angulata L.

Zhuang Jin; Mark S. Mashuta; Neal J. Stolowich; Abraham J. Vaisberg; Nicole S. Stivers; Paula J. Bates; Walter H. Lewis; Gerald B. Hammond

doi:10.1021/ol203498a

Physangulidines A, B, and C: Three new antiproliferative withanolides from Physalis angulata L.

Zhuang Jin
, Mark S. Mashuta
, Neal J. Stolowich
, Abraham J. Vaisberg
, Nicole S. Stivers
, Paula J. Bates
, Walter H. Lewis
, Gerald B. Hammond

School of Science and Engineering

University of Louisville
Washington University in St. Louis

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Bioassay-directed fractionation of the whole plant of Physalis angulata L. afforded three new antiproliferative withanolides with an unusual carbon framework: physangulidines A (1), B (2), and C (3). Structures of the three isomeric withanolides were determined by a combination of HRMS, NMR spectroscopic, and X-ray crystallographic methods. Each has shown significant antiproliferative activity against DU145 prostate cancer cells. Physangulidine A (1) was further tested against a wide range of additional cancer cell lines and found to exhibit significant antiproliferative activity.

Original language	English
Pages (from-to)	1230-1233
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	5
DOIs	https://doi.org/10.1021/ol203498a
State	Published - 2 Mar 2012

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title = "Physangulidines A, B, and C: Three new antiproliferative withanolides from Physalis angulata L.",

abstract = "Bioassay-directed fractionation of the whole plant of Physalis angulata L. afforded three new antiproliferative withanolides with an unusual carbon framework: physangulidines A (1), B (2), and C (3). Structures of the three isomeric withanolides were determined by a combination of HRMS, NMR spectroscopic, and X-ray crystallographic methods. Each has shown significant antiproliferative activity against DU145 prostate cancer cells. Physangulidine A (1) was further tested against a wide range of additional cancer cell lines and found to exhibit significant antiproliferative activity.",

author = "Zhuang Jin and Mashuta, \{Mark S.\} and Stolowich, \{Neal J.\} and Vaisberg, \{Abraham J.\} and Stivers, \{Nicole S.\} and Bates, \{Paula J.\} and Lewis, \{Walter H.\} and Hammond, \{Gerald B.\}",

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month = mar,

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doi = "10.1021/ol203498a",

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TY - JOUR

T1 - Physangulidines A, B, and C

T2 - Three new antiproliferative withanolides from Physalis angulata L.

AU - Jin, Zhuang

AU - Mashuta, Mark S.

AU - Stolowich, Neal J.

AU - Vaisberg, Abraham J.

AU - Stivers, Nicole S.

AU - Bates, Paula J.

AU - Lewis, Walter H.

AU - Hammond, Gerald B.

PY - 2012/3/2

Y1 - 2012/3/2

N2 - Bioassay-directed fractionation of the whole plant of Physalis angulata L. afforded three new antiproliferative withanolides with an unusual carbon framework: physangulidines A (1), B (2), and C (3). Structures of the three isomeric withanolides were determined by a combination of HRMS, NMR spectroscopic, and X-ray crystallographic methods. Each has shown significant antiproliferative activity against DU145 prostate cancer cells. Physangulidine A (1) was further tested against a wide range of additional cancer cell lines and found to exhibit significant antiproliferative activity.

AB - Bioassay-directed fractionation of the whole plant of Physalis angulata L. afforded three new antiproliferative withanolides with an unusual carbon framework: physangulidines A (1), B (2), and C (3). Structures of the three isomeric withanolides were determined by a combination of HRMS, NMR spectroscopic, and X-ray crystallographic methods. Each has shown significant antiproliferative activity against DU145 prostate cancer cells. Physangulidine A (1) was further tested against a wide range of additional cancer cell lines and found to exhibit significant antiproliferative activity.

UR - https://www.scopus.com/pages/publications/84857864013

U2 - 10.1021/ol203498a

DO - 10.1021/ol203498a

M3 - Artículo

C2 - 22329497

AN - SCOPUS:84857864013

SN - 1523-7060

VL - 14

SP - 1230

EP - 1233

JO - Organic Letters

JF - Organic Letters

IS - 5

ER -

Physangulidines A, B, and C: Three new antiproliferative withanolides from Physalis angulata L.

Abstract

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