Procedimiento para la infusión de mitocondrias autólogas por la arteria carótida en el cerebro porcino

Miguel A. Orrego; Samuel Levy; Cory Kelly; Gianfranco Arroyo; Luz Toribio; Hector H. García; Melanie Walker

doi:10.17843/rpmesp.2021.382.7768

Procedimiento para la infusión de mitocondrias autólogas por la arteria carótida en el cerebro porcino

Translated title of the contribution: Procedure for autologous mitochondria infusion via the carotid artery into porcine brain

Miguel A. Orrego
, Samuel Levy
, Cory Kelly
, Gianfranco Arroyo
, Luz Toribio
, Hector H. García
, Melanie Walker

University of Washington
Universidad Peruana Cayetano Heredia
Instituto Nacional de Ciencias Neurológicas

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Mitochondria are complex organelles that play a critical role within the cell; mitochondrial dysfunction can result in significant cell damage or death. Previous studies have demonstrated the promising therapeutic effects of autologous mitochondria transplantation into ischemic cardiac tissue; however, few studies have examined the in vivo effects of mitochondria infusion into the brain. The aim of this study is to report a procedure for carotid infusion of autologous mitochondria into porcine brains. By using this infusion technique, we propose that a selective and minimally invasive administration is feasible and may provide benefits in the treatment of various central nervous system disorders.

Translated title of the contribution	Procedure for autologous mitochondria infusion via the carotid artery into porcine brain
Original language	Spanish
Pages (from-to)	345-351
Number of pages	7
Journal	Revista Peruana de Medicina Experimental y Salud Publica
Volume	38
Issue number	2
DOIs	https://doi.org/10.17843/rpmesp.2021.382.7768
State	Published - 1 Apr 2021

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10.17843/rpmesp.2021.382.7768

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title = "Procedimiento para la infusi{\'o}n de mitocondrias aut{\'o}logas por la arteria car{\'o}tida en el cerebro porcino",

abstract = "Mitochondria are complex organelles that play a critical role within the cell; mitochondrial dysfunction can result in significant cell damage or death. Previous studies have demonstrated the promising therapeutic effects of autologous mitochondria transplantation into ischemic cardiac tissue; however, few studies have examined the in vivo effects of mitochondria infusion into the brain. The aim of this study is to report a procedure for carotid infusion of autologous mitochondria into porcine brains. By using this infusion technique, we propose that a selective and minimally invasive administration is feasible and may provide benefits in the treatment of various central nervous system disorders.",

keywords = "Brain, Carotid, Infusion, Microcatheter, Mitocondria, Porcine",

author = "Orrego, \{Miguel A.\} and Samuel Levy and Cory Kelly and Gianfranco Arroyo and Luz Toribio and Garc{\'i}a, \{Hector H.\} and Melanie Walker",

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doi = "10.17843/rpmesp.2021.382.7768",

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T1 - Procedimiento para la infusión de mitocondrias autólogas por la arteria carótida en el cerebro porcino

AU - Orrego, Miguel A.

AU - Levy, Samuel

AU - Kelly, Cory

AU - Arroyo, Gianfranco

AU - Toribio, Luz

AU - García, Hector H.

AU - Walker, Melanie

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Mitochondria are complex organelles that play a critical role within the cell; mitochondrial dysfunction can result in significant cell damage or death. Previous studies have demonstrated the promising therapeutic effects of autologous mitochondria transplantation into ischemic cardiac tissue; however, few studies have examined the in vivo effects of mitochondria infusion into the brain. The aim of this study is to report a procedure for carotid infusion of autologous mitochondria into porcine brains. By using this infusion technique, we propose that a selective and minimally invasive administration is feasible and may provide benefits in the treatment of various central nervous system disorders.

AB - Mitochondria are complex organelles that play a critical role within the cell; mitochondrial dysfunction can result in significant cell damage or death. Previous studies have demonstrated the promising therapeutic effects of autologous mitochondria transplantation into ischemic cardiac tissue; however, few studies have examined the in vivo effects of mitochondria infusion into the brain. The aim of this study is to report a procedure for carotid infusion of autologous mitochondria into porcine brains. By using this infusion technique, we propose that a selective and minimally invasive administration is feasible and may provide benefits in the treatment of various central nervous system disorders.

KW - Brain

KW - Carotid

KW - Infusion

KW - Microcatheter

KW - Mitocondria

KW - Porcine

UR - https://www.scopus.com/pages/publications/85114017932

U2 - 10.17843/rpmesp.2021.382.7768

DO - 10.17843/rpmesp.2021.382.7768

M3 - Artículo

C2 - 34468586

AN - SCOPUS:85114017932

SN - 1726-4634

VL - 38

SP - 345

EP - 351

JO - Revista Peruana de Medicina Experimental y Salud Publica

JF - Revista Peruana de Medicina Experimental y Salud Publica

IS - 2

ER -

Procedimiento para la infusión de mitocondrias autólogas por la arteria carótida en el cerebro porcino

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