TY - JOUR
T1 - Recent HIV infection and annualized HIV incidence rates among sexual and gender minorities in Brazil and Peru (ImPrEP seroincidence study)
T2 - a cross-sectional, multicenter study
AU - ImPrEP Seroincidence Study Group
AU - Torres, Thiago S.
AU - Teixeira, Sylvia L.M.
AU - Hoagland, Brenda
AU - Konda, Kelika A.
AU - Derrico, Monica
AU - Moreira, Ronaldo I.
AU - Guanira, Juan V.
AU - Benedetti, Marcos
AU - Nazer, Sandro
AU - Calvo, Gino M.
AU - Vargas, Silver
AU - Benites, Carlos
AU - Bigolin, Álisson
AU - Alonso Neto, José Boullosa
AU - Farias, Alessandro
AU - Guimarães Lacerda, Marcos Vinícius
AU - Raenck Silva, Daila Alena
AU - Paz, Leidijany Costa
AU - Madruga, José Valdez
AU - Salvatierra Flores, Hector Javier
AU - Boluarte, Ginjaylan Prada
AU - Osco Tamayo, Cesar Vidal
AU - Castro Antezana, Hardy Teresa
AU - Pimenta, M. Cristina
AU - Bórquez, Annick
AU - Luz, Paula M.
AU - Grinsztejn, Beatriz
AU - Szwarcwald, Celia Landmann
AU - Cáceres, Carlos F.
AU - Veloso, Valdilea G.
AU - Kristic, Tania
AU - Rocha, Carla
AU - da Silva Santos, Willian
AU - Lovreto Santana, Ana Paula
AU - Lima, Renato
AU - Souza, Carolina
AU - Oliva, Talita Andrade
AU - Valões, Mônica dos Santos
AU - Olivetto, Jennifer
AU - Mota, Gabriel Lima
AU - Cano, Aline Barnabé
AU - Trefiglio, Roberta
AU - Coutinho, Carolina
AU - Elorreaga, Oliver
AU - Gutierrez, Ximena
AU - Olivos, Fernando
AU - Caviedes, Damaris
AU - Adriazola, Daniella
AU - Juárez, Eduardo
AU - Mariño, Gabriela
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/12
Y1 - 2023/12
N2 - Background: HIV incidence estimation is critical for monitoring the HIV epidemic dynamics and the effectiveness of public health prevention interventions. We aimed to identify sexual and gender minorities (SGM) with recent HIV infections, factors associated with recent HIV infection, and to estimate annualised HIV incidence rates. Methods: Cross-sectional multicentre study in HIV testing services in Brazil and Peru (15 cities). Inclusion criteria: 18+ years, SGM assigned male at birth, not using pre-/post-exposure prophylaxis. We identified recent HIV infection using the Maxim HIV-1 LAg-Avidity EIA assay as part of a recent infection testing algorithm (RITA). Annualized HIV incidence was calculated using the UNAIDS/WHO incidence estimator tool. Multivariable logistic regression models were used to estimate factors associated with recent HIV infection. Trial registration: NCT05674682. Findings: From 31-Jan-2021 to 29-May-2022, 6899 individuals participated [Brazil: 4586 (66.5%); Peru: 2313 (33.5%)]; 5946 (86.2%) cisgender men, 751 (10.9%) transgender women and 202 (2.9%) non-binary/gender diverse. Median age was 27 (IQR: 23–34) years. HIV prevalence was 11.4% (N = 784/6899); 137 (2.0%) SGM were identified with recent HIV infection. The overall annualized HIV incidence rate was 3.88% (95% CI: 2.86–4.87); Brazil: 2.62% (95% CI: 1.78–3.43); Peru: 6.69% (95% CI: 4.62–8.69). Participants aged 18–24 years had higher odds of recent HIV infection compared to those aged 30+ years in both countries. Interpretation: Our results highlight the significant burden of HIV epidemic among SGM in large urban centres of Brazil and Peru. Public health policies and interventions to increase access to effective HIV prevention methods such as PrEP are urgently needed in Latin America. Funding: Unitaid, WHO ( Switzerland), Ministry of Health from Brazil and Peru.
AB - Background: HIV incidence estimation is critical for monitoring the HIV epidemic dynamics and the effectiveness of public health prevention interventions. We aimed to identify sexual and gender minorities (SGM) with recent HIV infections, factors associated with recent HIV infection, and to estimate annualised HIV incidence rates. Methods: Cross-sectional multicentre study in HIV testing services in Brazil and Peru (15 cities). Inclusion criteria: 18+ years, SGM assigned male at birth, not using pre-/post-exposure prophylaxis. We identified recent HIV infection using the Maxim HIV-1 LAg-Avidity EIA assay as part of a recent infection testing algorithm (RITA). Annualized HIV incidence was calculated using the UNAIDS/WHO incidence estimator tool. Multivariable logistic regression models were used to estimate factors associated with recent HIV infection. Trial registration: NCT05674682. Findings: From 31-Jan-2021 to 29-May-2022, 6899 individuals participated [Brazil: 4586 (66.5%); Peru: 2313 (33.5%)]; 5946 (86.2%) cisgender men, 751 (10.9%) transgender women and 202 (2.9%) non-binary/gender diverse. Median age was 27 (IQR: 23–34) years. HIV prevalence was 11.4% (N = 784/6899); 137 (2.0%) SGM were identified with recent HIV infection. The overall annualized HIV incidence rate was 3.88% (95% CI: 2.86–4.87); Brazil: 2.62% (95% CI: 1.78–3.43); Peru: 6.69% (95% CI: 4.62–8.69). Participants aged 18–24 years had higher odds of recent HIV infection compared to those aged 30+ years in both countries. Interpretation: Our results highlight the significant burden of HIV epidemic among SGM in large urban centres of Brazil and Peru. Public health policies and interventions to increase access to effective HIV prevention methods such as PrEP are urgently needed in Latin America. Funding: Unitaid, WHO ( Switzerland), Ministry of Health from Brazil and Peru.
KW - HIV
KW - HIV incidence rate
KW - HIV recency
KW - HIV seroincidence
KW - Latin America
KW - Public health
KW - Sexual and gender minorities
UR - https://www.scopus.com/pages/publications/85178165091
U2 - 10.1016/j.lana.2023.100642
DO - 10.1016/j.lana.2023.100642
M3 - Artículo
AN - SCOPUS:85178165091
SN - 2667-193X
VL - 28
JO - The Lancet Regional Health - Americas
JF - The Lancet Regional Health - Americas
M1 - 100642
ER -
SDG 3 Good Health and Well-being
SDG 5 Gender Equality