TY - JOUR
T1 - Rio Mamore Hantavirus Endemicity, Peruvian Amazon, 2020
AU - Piche-Ovares, Marta
AU - Paquita García, Maria
AU - Moreira-Soto, Andres
AU - Figueroa-Romero, Maribel Dana
AU - Merino-Sarmiento, Nancy Susy
AU - Marcelo-Ñique, Adolfo Ismael
AU - Málaga-Trillo, Edward
AU - Manosalva, Dora Esther Valencia
AU - Gatty-Nogueira, Miladi
AU - Sanchez, César Augusto Cabezas
AU - Drexler, Jan Felix
N1 - Publisher Copyright:
© 2024 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2024/12
Y1 - 2024/12
N2 - To explore hantavirus infection patterns in Latin America, we conducted molecular and serologic hantavirus investigations among 3,400 febrile patients from Peru during 2020–2021. Reverse transcription PCR indicated that a patient from Loreto, in the Peruvian Amazon, was positive for Rio Mamore hantavirus (serum, 3.8 × 103 copies/mL). High genomic sequence identity of 87.0%–94.8% and phylogenetic common ancestry with a rodent-associated Rio Mamore hantavirus from Loreto in 1996 indicated endemicity. In 832 samples from Loreto, hantavirus incidence based on IgM ELISA of pooled Sin Nombre (SNV) and Andes virus (ANDV) nucleoproteins and immunofluorescence assay–based end-point titration using SNV/ANDV/ Hantaan/Puumala/Saarema/Dobrava/Seoul hantaviruses was 0.5%. Across 3 ecologically distinct departments in Peru, SNV/ANDV IgG ELISA/IFA–based reactivity was 1.7%, suggesting circulation of antigenically distinct New World hantaviruses. Testing for arboviruses, nonendemic pathogens, and antigen-free ELISA corroborated nonspecific reactivity in 2 IgG and several IgM ELISA–positive serum samples. Hantavirus diagnostics and surveillance should be strengthened in Peru and across Latin America..
AB - To explore hantavirus infection patterns in Latin America, we conducted molecular and serologic hantavirus investigations among 3,400 febrile patients from Peru during 2020–2021. Reverse transcription PCR indicated that a patient from Loreto, in the Peruvian Amazon, was positive for Rio Mamore hantavirus (serum, 3.8 × 103 copies/mL). High genomic sequence identity of 87.0%–94.8% and phylogenetic common ancestry with a rodent-associated Rio Mamore hantavirus from Loreto in 1996 indicated endemicity. In 832 samples from Loreto, hantavirus incidence based on IgM ELISA of pooled Sin Nombre (SNV) and Andes virus (ANDV) nucleoproteins and immunofluorescence assay–based end-point titration using SNV/ANDV/ Hantaan/Puumala/Saarema/Dobrava/Seoul hantaviruses was 0.5%. Across 3 ecologically distinct departments in Peru, SNV/ANDV IgG ELISA/IFA–based reactivity was 1.7%, suggesting circulation of antigenically distinct New World hantaviruses. Testing for arboviruses, nonendemic pathogens, and antigen-free ELISA corroborated nonspecific reactivity in 2 IgG and several IgM ELISA–positive serum samples. Hantavirus diagnostics and surveillance should be strengthened in Peru and across Latin America..
UR - https://www.scopus.com/pages/publications/85210364148
U2 - 10.3201/eid3012.240249
DO - 10.3201/eid3012.240249
M3 - Artículo
C2 - 39592268
AN - SCOPUS:85210364148
SN - 1080-6040
VL - 30
SP - 2532
EP - 2543
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 12
ER -