Safety, immunogenicity, and excretion pattern of single-dose live oral cholera vaccine CVD 103-HgR in Peruvian adults of high and low socioeconomic levels

E. Gotuzzo; B. Butron; C. Seas; M. Penny; R. Ruiz; G. Losonsky; C. F. Lanata; S. S. Wasserman; E. Salazar; J. B. Kaper; S. Cryz; M. M. Levine

Safety, immunogenicity, and excretion pattern of single-dose live oral cholera vaccine CVD 103-HgR in Peruvian adults of high and low socioeconomic levels

E. Gotuzzo
, B. Butron
, C. Seas
, M. Penny
, R. Ruiz
, G. Losonsky
, C. F. Lanata
, S. S. Wasserman
, E. Salazar
, J. B. Kaper
, S. Cryz
, M. M. Levine

Universidad Peruana Cayetano Heredia

Research output: Contribution to journal › Comment/debate

106 Scopus citations

Abstract

Groups of 122 Peruvian adults of low socioeconomic level (SEL) and 125 of high SEL received a randomly allocated 5 x 10⁹- or 5 x 10⁸-CFU dose of CVD 103-HgR live oral cholera vaccine or a placebo. The vaccine was well tolerated. Vibriocidal seroconversions occurred in 78% of high-SEL and 72% of low-SEL subjects who ingested the high dose and in 78 and 49%, respectively, of those who received the low dose.

Original language	English
Pages (from-to)	3994-3997
Number of pages	4
Journal	Infection and Immunity
Volume	61
Issue number	9
State	Published - 1993

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

@article{e75ad2d412ca418d84785089ad65285e,

title = "Safety, immunogenicity, and excretion pattern of single-dose live oral cholera vaccine CVD 103-HgR in Peruvian adults of high and low socioeconomic levels",

abstract = "Groups of 122 Peruvian adults of low socioeconomic level (SEL) and 125 of high SEL received a randomly allocated 5 x 109- or 5 x 108-CFU dose of CVD 103-HgR live oral cholera vaccine or a placebo. The vaccine was well tolerated. Vibriocidal seroconversions occurred in 78\% of high-SEL and 72\% of low-SEL subjects who ingested the high dose and in 78 and 49\%, respectively, of those who received the low dose.",

author = "E. Gotuzzo and B. Butron and C. Seas and M. Penny and R. Ruiz and G. Losonsky and Lanata, \{C. F.\} and Wasserman, \{S. S.\} and E. Salazar and Kaper, \{J. B.\} and S. Cryz and Levine, \{M. M.\}",

year = "1993",

language = "Ingl{\'e}s",

volume = "61",

pages = "3994--3997",

journal = "Infection and Immunity",

issn = "0019-9567",

number = "9",

}

TY - JOUR

T1 - Safety, immunogenicity, and excretion pattern of single-dose live oral cholera vaccine CVD 103-HgR in Peruvian adults of high and low socioeconomic levels

AU - Gotuzzo, E.

AU - Butron, B.

AU - Seas, C.

AU - Penny, M.

AU - Ruiz, R.

AU - Losonsky, G.

AU - Lanata, C. F.

AU - Wasserman, S. S.

AU - Salazar, E.

AU - Kaper, J. B.

AU - Cryz, S.

AU - Levine, M. M.

PY - 1993

Y1 - 1993

N2 - Groups of 122 Peruvian adults of low socioeconomic level (SEL) and 125 of high SEL received a randomly allocated 5 x 109- or 5 x 108-CFU dose of CVD 103-HgR live oral cholera vaccine or a placebo. The vaccine was well tolerated. Vibriocidal seroconversions occurred in 78% of high-SEL and 72% of low-SEL subjects who ingested the high dose and in 78 and 49%, respectively, of those who received the low dose.

AB - Groups of 122 Peruvian adults of low socioeconomic level (SEL) and 125 of high SEL received a randomly allocated 5 x 109- or 5 x 108-CFU dose of CVD 103-HgR live oral cholera vaccine or a placebo. The vaccine was well tolerated. Vibriocidal seroconversions occurred in 78% of high-SEL and 72% of low-SEL subjects who ingested the high dose and in 78 and 49%, respectively, of those who received the low dose.

UR - https://www.scopus.com/pages/publications/0027304310

M3 - Comentario/Debate

C2 - 8359923

AN - SCOPUS:0027304310

SN - 0019-9567

VL - 61

SP - 3994

EP - 3997

JO - Infection and Immunity

JF - Infection and Immunity

IS - 9

ER -

Safety, immunogenicity, and excretion pattern of single-dose live oral cholera vaccine CVD 103-HgR in Peruvian adults of high and low socioeconomic levels

Abstract

UN SDGs

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