Secretory Immunoglobulin A Against Type-III Secretion System Proteins of Pseudomonas aeruginosa in Human Colostrum

Luis Cabrera-Sosa; David Durand; Theresa J. Ochoa

doi:10.1097/INF.0000000000004892

Secretory Immunoglobulin A Against Type-III Secretion System Proteins of Pseudomonas aeruginosa in Human Colostrum

Luis Cabrera-Sosa
, David Durand
, Theresa J. Ochoa

Instituto de Medicina Tropical
Universidad Peruana Cayetano Heredia, Facultad de Medicina Alberto Hurtado

Research output: Contribution to journal › Article › peer-review

Abstract

We determined secretory Immunoglobulin A (sIgA) against type-III secretion system proteins (ExoS, ExoT, PopB and PopB) of Pseudomonas aeruginosa in colostrum of 150 Peruvian women using Western blot. We found 142 (94.7%) samples with at least one sIgA. The presence of sIgA against all 4 proteins was the most common profile (43%). These antibodies may protect newborns from P. aeruginosa infections.

Original language	English
Pages (from-to)	e437-e439
Journal	Pediatric Infectious Disease Journal
Volume	44
Issue number	12
DOIs	https://doi.org/10.1097/INF.0000000000004892
State	Published - Nov 2025
Externally published	Yes

Keywords

Pseudomonas aeruginosa
colostrum
secretory immunoglobulin A
type 3 secretion system

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10.1097/INF.0000000000004892

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abstract = "We determined secretory Immunoglobulin A (sIgA) against type-III secretion system proteins (ExoS, ExoT, PopB and PopB) of Pseudomonas aeruginosa in colostrum of 150 Peruvian women using Western blot. We found 142 (94.7\%) samples with at least one sIgA. The presence of sIgA against all 4 proteins was the most common profile (43\%). These antibodies may protect newborns from P. aeruginosa infections.",

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AB - We determined secretory Immunoglobulin A (sIgA) against type-III secretion system proteins (ExoS, ExoT, PopB and PopB) of Pseudomonas aeruginosa in colostrum of 150 Peruvian women using Western blot. We found 142 (94.7%) samples with at least one sIgA. The presence of sIgA against all 4 proteins was the most common profile (43%). These antibodies may protect newborns from P. aeruginosa infections.

KW - Pseudomonas aeruginosa

KW - colostrum

KW - secretory immunoglobulin A

KW - type 3 secretion system

UR - https://www.scopus.com/pages/publications/105015071673

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ER -

Secretory Immunoglobulin A Against Type-III Secretion System Proteins of Pseudomonas aeruginosa in Human Colostrum

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Keywords

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