Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: Implications for pre-exposure prophylaxis adherence monitoring

Monica Gandhi; David V. Glidden; Albert Liu; Peter L. Anderson; Howard Horng; Patricia Defechereux; Juan V. Guanira; Beatriz Grinsztejn; Suwat Chariyalertsak; Linda Gail Bekker; Robert M. Grant

doi:10.1093/infdis/jiv239

Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: Implications for pre-exposure prophylaxis adherence monitoring

Monica Gandhi
, David V. Glidden
, Albert Liu
, Peter L. Anderson
, Howard Horng
, Patricia Defechereux
, Juan V. Guanira
, Beatriz Grinsztejn
, Suwat Chariyalertsak
, Linda Gail Bekker
, Robert M. Grant

University of California San Francisco
San Francisco Department of Public Health
University of Colorado Denver
University of California San Francisco Center for Tuberculosis
Gladstone Institutes
Investigaciones Medicas en Salud
Instituto Nacional de Infectologia Evandro Chagas (INI)
Chiang Mai University
University of Cape Town

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Self-reported adherence to pre-exposure prophylaxis (PrEP) has limitations, raising interest in pharmacologic monitoring. Drug concentrations in hair and dried blood spots (DBS) are used to assess long-term-exposure; hair shipment/storage occurs at room temperature. The iPrEx Open Label Extension collected DBS routinely, with opt-in hair collection; concentrations were measured with liquid chromatography/tandem mass spectrometry. In 806 hair-DBS pairs, tenofovir (TFV) hair levels and TFV diphosphate (DP) in DBS were strongly correlated (Spearman coefficient r = 0.734; P <. 001), as were hair TFV/DBS emtricitabine (FTC) triphosphate (TP) (r = 0.781; P <. 001); hair FTC/DBS TFV-DP (r = 0.74; P <. 001); hair FTC/DBS FTC-TP (r = 0.587; P <. 001). Drug detectability was generally concordant by matrix. Hair TFV/FTC concentrations correlate strongly with DBS levels, which are predictive of PrEP outcomes.

Original language	English
Pages (from-to)	1402-1406
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	212
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jiv239
State	Published - 1 Nov 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 5 Gender Equality

Keywords

HIV prevention
PrEP
adherence
dried blood spot (DBS) concentrations
hair concentrations
iPrEx Open Label Extension (OLE)
pharmacologic monitoring
pre-exposure prophylaxis
tenofovir/emtricitabine

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Gandhi, M., Glidden, D. V., Liu, A., Anderson, P. L., Horng, H., Defechereux, P., Guanira, J. V., Grinsztejn, B., Chariyalertsak, S., Bekker, L. G., & Grant, R. M. (2015). Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: Implications for pre-exposure prophylaxis adherence monitoring. Journal of Infectious Diseases, 212(9), 1402-1406. https://doi.org/10.1093/infdis/jiv239

Gandhi, Monica ; Glidden, David V. ; Liu, Albert et al. / Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension : Implications for pre-exposure prophylaxis adherence monitoring. In: Journal of Infectious Diseases. 2015 ; Vol. 212, No. 9. pp. 1402-1406.

@article{4f70ed366c66436cb8bd13bff7debd96,

title = "Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: Implications for pre-exposure prophylaxis adherence monitoring",

abstract = "Self-reported adherence to pre-exposure prophylaxis (PrEP) has limitations, raising interest in pharmacologic monitoring. Drug concentrations in hair and dried blood spots (DBS) are used to assess long-term-exposure; hair shipment/storage occurs at room temperature. The iPrEx Open Label Extension collected DBS routinely, with opt-in hair collection; concentrations were measured with liquid chromatography/tandem mass spectrometry. In 806 hair-DBS pairs, tenofovir (TFV) hair levels and TFV diphosphate (DP) in DBS were strongly correlated (Spearman coefficient r = 0.734; P <. 001), as were hair TFV/DBS emtricitabine (FTC) triphosphate (TP) (r = 0.781; P <. 001); hair FTC/DBS TFV-DP (r = 0.74; P <. 001); hair FTC/DBS FTC-TP (r = 0.587; P <. 001). Drug detectability was generally concordant by matrix. Hair TFV/FTC concentrations correlate strongly with DBS levels, which are predictive of PrEP outcomes.",

keywords = "HIV prevention, PrEP, adherence, dried blood spot (DBS) concentrations, hair concentrations, iPrEx Open Label Extension (OLE), pharmacologic monitoring, pre-exposure prophylaxis, tenofovir/emtricitabine",

author = "Monica Gandhi and Glidden, \{David V.\} and Albert Liu and Anderson, \{Peter L.\} and Howard Horng and Patricia Defechereux and Guanira, \{Juan V.\} and Beatriz Grinsztejn and Suwat Chariyalertsak and Bekker, \{Linda Gail\} and Grant, \{Robert M.\}",

note = "Publisher Copyright: {\textcopyright} The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.",

year = "2015",

month = nov,

day = "1",

doi = "10.1093/infdis/jiv239",

language = "Ingl{\'e}s",

volume = "212",

pages = "1402--1406",

journal = "Journal of Infectious Diseases",

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Gandhi, M, Glidden, DV, Liu, A, Anderson, PL, Horng, H, Defechereux, P, Guanira, JV, Grinsztejn, B, Chariyalertsak, S, Bekker, LG & Grant, RM 2015, 'Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: Implications for pre-exposure prophylaxis adherence monitoring', Journal of Infectious Diseases, vol. 212, no. 9, pp. 1402-1406. https://doi.org/10.1093/infdis/jiv239

Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: Implications for pre-exposure prophylaxis adherence monitoring. / Gandhi, Monica; Glidden, David V.; Liu, Albert et al.
In: Journal of Infectious Diseases, Vol. 212, No. 9, 01.11.2015, p. 1402-1406.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension

T2 - Implications for pre-exposure prophylaxis adherence monitoring

AU - Gandhi, Monica

AU - Glidden, David V.

AU - Liu, Albert

AU - Anderson, Peter L.

AU - Horng, Howard

AU - Defechereux, Patricia

AU - Guanira, Juan V.

AU - Grinsztejn, Beatriz

AU - Chariyalertsak, Suwat

AU - Bekker, Linda Gail

AU - Grant, Robert M.

N1 - Publisher Copyright: © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Self-reported adherence to pre-exposure prophylaxis (PrEP) has limitations, raising interest in pharmacologic monitoring. Drug concentrations in hair and dried blood spots (DBS) are used to assess long-term-exposure; hair shipment/storage occurs at room temperature. The iPrEx Open Label Extension collected DBS routinely, with opt-in hair collection; concentrations were measured with liquid chromatography/tandem mass spectrometry. In 806 hair-DBS pairs, tenofovir (TFV) hair levels and TFV diphosphate (DP) in DBS were strongly correlated (Spearman coefficient r = 0.734; P <. 001), as were hair TFV/DBS emtricitabine (FTC) triphosphate (TP) (r = 0.781; P <. 001); hair FTC/DBS TFV-DP (r = 0.74; P <. 001); hair FTC/DBS FTC-TP (r = 0.587; P <. 001). Drug detectability was generally concordant by matrix. Hair TFV/FTC concentrations correlate strongly with DBS levels, which are predictive of PrEP outcomes.

AB - Self-reported adherence to pre-exposure prophylaxis (PrEP) has limitations, raising interest in pharmacologic monitoring. Drug concentrations in hair and dried blood spots (DBS) are used to assess long-term-exposure; hair shipment/storage occurs at room temperature. The iPrEx Open Label Extension collected DBS routinely, with opt-in hair collection; concentrations were measured with liquid chromatography/tandem mass spectrometry. In 806 hair-DBS pairs, tenofovir (TFV) hair levels and TFV diphosphate (DP) in DBS were strongly correlated (Spearman coefficient r = 0.734; P <. 001), as were hair TFV/DBS emtricitabine (FTC) triphosphate (TP) (r = 0.781; P <. 001); hair FTC/DBS TFV-DP (r = 0.74; P <. 001); hair FTC/DBS FTC-TP (r = 0.587; P <. 001). Drug detectability was generally concordant by matrix. Hair TFV/FTC concentrations correlate strongly with DBS levels, which are predictive of PrEP outcomes.

KW - HIV prevention

KW - PrEP

KW - adherence

KW - dried blood spot (DBS) concentrations

KW - hair concentrations

KW - iPrEx Open Label Extension (OLE)

KW - pharmacologic monitoring

KW - pre-exposure prophylaxis

KW - tenofovir/emtricitabine

UR - https://www.scopus.com/pages/publications/84946126981

U2 - 10.1093/infdis/jiv239

DO - 10.1093/infdis/jiv239

M3 - Artículo

C2 - 25895984

AN - SCOPUS:84946126981

SN - 0022-1899

VL - 212

SP - 1402

EP - 1406

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 9

ER -

Gandhi M, Glidden DV, Liu A, Anderson PL, Horng H, Defechereux P et al. Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: Implications for pre-exposure prophylaxis adherence monitoring. Journal of Infectious Diseases. 2015 Nov 1;212(9):1402-1406. doi: 10.1093/infdis/jiv239

Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: Implications for pre-exposure prophylaxis adherence monitoring

Abstract

UN SDGs

Keywords

Access to Document

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