The effect of inositol hexaphosphate in the high-affinity hemoglobin of the Andean chicken (Gallus gallus)

O. Mejía; F. León-Velarde; C. Monge-C.

doi:10.1016/0305-0491(94)90026-4

The effect of inositol hexaphosphate in the high-affinity hemoglobin of the Andean chicken (Gallus gallus)

O. Mejía
, F. León-Velarde
, C. Monge-C.

Graduate School

Universidad Peruana Cayetano Heredia

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A strain of high-altitude chickens (Gallus gallus) with a high hemoglobin-oxygen affinity has been found in the Peruvian Andes. The purpose in this work was to investigate the relation of this high affinity with the allosteric regulation of the inositol hexaphosphate effector (IHP). The hemoglobin-oxygen affinity has been determined in phosphate-free hemoglobin solutions before and after the addition of IHP. The results showed that the addition of IHP to the phosphate-free hemoglobin solutions increased the affinity significantly less in the high-altitude chicken (26.3 Torr) than in the sea-level chicken (42.2 Torr) (P < 0.001). It was concluded that the high-affinity hemoglobin is probably dependent on a molecular change affecting the allosteric regulation, although a change in the intrinsic properties of the hemoglobin cannot be discarded.

Original language	English
Pages (from-to)	437-441
Number of pages	5
Journal	Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Volume	109
Issue number	2-3
DOIs	https://doi.org/10.1016/0305-0491(94)90026-4
State	Published - 1994

Keywords

Adaptation
Chicken
Hemoglobin affinity
High altitude
Hypoxia
Inositol hexaphosphate
Inositol pentaphosphate
P50

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10.1016/0305-0491(94)90026-4

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title = "The effect of inositol hexaphosphate in the high-affinity hemoglobin of the Andean chicken (Gallus gallus)",

abstract = "A strain of high-altitude chickens (Gallus gallus) with a high hemoglobin-oxygen affinity has been found in the Peruvian Andes. The purpose in this work was to investigate the relation of this high affinity with the allosteric regulation of the inositol hexaphosphate effector (IHP). The hemoglobin-oxygen affinity has been determined in phosphate-free hemoglobin solutions before and after the addition of IHP. The results showed that the addition of IHP to the phosphate-free hemoglobin solutions increased the affinity significantly less in the high-altitude chicken (26.3 Torr) than in the sea-level chicken (42.2 Torr) (P < 0.001). It was concluded that the high-affinity hemoglobin is probably dependent on a molecular change affecting the allosteric regulation, although a change in the intrinsic properties of the hemoglobin cannot be discarded.",

keywords = "Adaptation, Chicken, Hemoglobin affinity, High altitude, Hypoxia, Inositol hexaphosphate, Inositol pentaphosphate, P50",

author = "O. Mej{\'i}a and F. Le{\'o}n-Velarde and C. Monge-C.",

year = "1994",

doi = "10.1016/0305-0491(94)90026-4",

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journal = "Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology",

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TY - JOUR

T1 - The effect of inositol hexaphosphate in the high-affinity hemoglobin of the Andean chicken (Gallus gallus)

AU - Mejía, O.

AU - León-Velarde, F.

AU - Monge-C., C.

PY - 1994

Y1 - 1994

N2 - A strain of high-altitude chickens (Gallus gallus) with a high hemoglobin-oxygen affinity has been found in the Peruvian Andes. The purpose in this work was to investigate the relation of this high affinity with the allosteric regulation of the inositol hexaphosphate effector (IHP). The hemoglobin-oxygen affinity has been determined in phosphate-free hemoglobin solutions before and after the addition of IHP. The results showed that the addition of IHP to the phosphate-free hemoglobin solutions increased the affinity significantly less in the high-altitude chicken (26.3 Torr) than in the sea-level chicken (42.2 Torr) (P < 0.001). It was concluded that the high-affinity hemoglobin is probably dependent on a molecular change affecting the allosteric regulation, although a change in the intrinsic properties of the hemoglobin cannot be discarded.

AB - A strain of high-altitude chickens (Gallus gallus) with a high hemoglobin-oxygen affinity has been found in the Peruvian Andes. The purpose in this work was to investigate the relation of this high affinity with the allosteric regulation of the inositol hexaphosphate effector (IHP). The hemoglobin-oxygen affinity has been determined in phosphate-free hemoglobin solutions before and after the addition of IHP. The results showed that the addition of IHP to the phosphate-free hemoglobin solutions increased the affinity significantly less in the high-altitude chicken (26.3 Torr) than in the sea-level chicken (42.2 Torr) (P < 0.001). It was concluded that the high-affinity hemoglobin is probably dependent on a molecular change affecting the allosteric regulation, although a change in the intrinsic properties of the hemoglobin cannot be discarded.

KW - Adaptation

KW - Chicken

KW - Hemoglobin affinity

KW - High altitude

KW - Hypoxia

KW - Inositol hexaphosphate

KW - Inositol pentaphosphate

KW - P50

UR - https://www.scopus.com/pages/publications/0028081486

U2 - 10.1016/0305-0491(94)90026-4

DO - 10.1016/0305-0491(94)90026-4

M3 - Artículo

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AN - SCOPUS:0028081486

SN - 0305-0491

VL - 109

SP - 437

EP - 441

JO - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

JF - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

IS - 2-3

ER -

The effect of inositol hexaphosphate in the high-affinity hemoglobin of the Andean chicken (Gallus gallus)

Abstract

Keywords

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