Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera

P. Orejuela; A. Zavaleta; M. Salas; N. Marsh

doi:10.1016/0041-0101(91)90212-A

Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera

P. Orejuela
, A. Zavaleta
, M. Salas
, N. Marsh

Universidad Peruana Cayetano Heredia
Instituto Nacional de Salud del Perú
King’s College London

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

P. Orejuela, A. Zavaleta, M. Salas and N. Marsh. Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera. Toxicon 29, 1151-1154, 1991.-Venoms from Lachesis muta muta, Bothrops pictus, B. barnetti, B. atrox and B. hyoprorus coagulate in vitro canine fibrinogen, and both bovine fibrinogen and bovine plasma. B. barnetti and L. muta muta venoms have greater activity on canine fibrinogen and B. atrox and B. hyoprorus venoms, a greater activity on bovine fibrinogen. Gel filtration showed one peak of coagulant activity in all venoms except B. atrox venom which possessed two peaks. The apparent mol. wt of these enzymes ranged from 45,000 to 69,000.

Original language	English
Pages (from-to)	1151-1154
Number of pages	4
Journal	Toxicon
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/0041-0101(91)90212-A
State	Published - 1991

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title = "Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera",

abstract = "P. Orejuela, A. Zavaleta, M. Salas and N. Marsh. Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera. Toxicon 29, 1151-1154, 1991.-Venoms from Lachesis muta muta, Bothrops pictus, B. barnetti, B. atrox and B. hyoprorus coagulate in vitro canine fibrinogen, and both bovine fibrinogen and bovine plasma. B. barnetti and L. muta muta venoms have greater activity on canine fibrinogen and B. atrox and B. hyoprorus venoms, a greater activity on bovine fibrinogen. Gel filtration showed one peak of coagulant activity in all venoms except B. atrox venom which possessed two peaks. The apparent mol. wt of these enzymes ranged from 45,000 to 69,000.",

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AU - Salas, M.

AU - Marsh, N.

PY - 1991

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N2 - P. Orejuela, A. Zavaleta, M. Salas and N. Marsh. Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera. Toxicon 29, 1151-1154, 1991.-Venoms from Lachesis muta muta, Bothrops pictus, B. barnetti, B. atrox and B. hyoprorus coagulate in vitro canine fibrinogen, and both bovine fibrinogen and bovine plasma. B. barnetti and L. muta muta venoms have greater activity on canine fibrinogen and B. atrox and B. hyoprorus venoms, a greater activity on bovine fibrinogen. Gel filtration showed one peak of coagulant activity in all venoms except B. atrox venom which possessed two peaks. The apparent mol. wt of these enzymes ranged from 45,000 to 69,000.

AB - P. Orejuela, A. Zavaleta, M. Salas and N. Marsh. Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera. Toxicon 29, 1151-1154, 1991.-Venoms from Lachesis muta muta, Bothrops pictus, B. barnetti, B. atrox and B. hyoprorus coagulate in vitro canine fibrinogen, and both bovine fibrinogen and bovine plasma. B. barnetti and L. muta muta venoms have greater activity on canine fibrinogen and B. atrox and B. hyoprorus venoms, a greater activity on bovine fibrinogen. Gel filtration showed one peak of coagulant activity in all venoms except B. atrox venom which possessed two peaks. The apparent mol. wt of these enzymes ranged from 45,000 to 69,000.

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Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera

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