Ventilatory response to severe acute hypoxia in guinea-pigs and rats with high hemoglobin-oxygen affinity induced by cyanate

M. Rivera-Ch; F. León-Velarde; L. Huicho; C. Monge-C

doi:10.1016/0300-9629(94)90209-7

Ventilatory response to severe acute hypoxia in guinea-pigs and rats with high hemoglobin-oxygen affinity induced by cyanate

Universidad Peruana Cayetano Heredia

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Baseline ventilation, hemoglobin concentration (Hb) and P50 were significantly lower in guinea-pigs than in rats. Chronic sodium cyanate (NaOCN) administration did not significantly increase hemoglobin concentration in either guinea-pigs or rats. It decreased the P50 significantly less in guinea-pigs than in rats. The high Hb-O₂ affinity experimentally induced did not modify the hypoxic ventilatory response (HVR) of guinea-pigs and rats. At the same level of acute hypoxia, HVR was significantly lower in NaOCN guinea-pigs than in NaOCN rats. Guinea-pigs, genotypically adapted animals to high altitude, displayed relatively minor ventilatory and Hb-O₂ affinity changes to NaOCN, and a relatively minor HVR to acute hypoxia. They probably use tissue and biochemical adaptive mechanisms, in addition to their limited extracellular responses to successfully tolerate ambient hypoxia.

Original language	English
Pages (from-to)	675-680
Number of pages	6
Journal	Comparative Biochemistry and Physiology -- Part A: Physiology
Volume	109
Issue number	3
DOIs	https://doi.org/10.1016/0300-9629(94)90209-7
State	Published - Nov 1994

Keywords

Altitude
Cyanate
Genetic adaptation
Guinea-pig
Hemoglobin-oxygen affinity
Hypoxia
Hypoxic ventilatory response
Ventilation

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10.1016/0300-9629(94)90209-7

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title = "Ventilatory response to severe acute hypoxia in guinea-pigs and rats with high hemoglobin-oxygen affinity induced by cyanate",

abstract = "Baseline ventilation, hemoglobin concentration (Hb) and P50 were significantly lower in guinea-pigs than in rats. Chronic sodium cyanate (NaOCN) administration did not significantly increase hemoglobin concentration in either guinea-pigs or rats. It decreased the P50 significantly less in guinea-pigs than in rats. The high Hb-O2 affinity experimentally induced did not modify the hypoxic ventilatory response (HVR) of guinea-pigs and rats. At the same level of acute hypoxia, HVR was significantly lower in NaOCN guinea-pigs than in NaOCN rats. Guinea-pigs, genotypically adapted animals to high altitude, displayed relatively minor ventilatory and Hb-O2 affinity changes to NaOCN, and a relatively minor HVR to acute hypoxia. They probably use tissue and biochemical adaptive mechanisms, in addition to their limited extracellular responses to successfully tolerate ambient hypoxia.",

keywords = "Altitude, Cyanate, Genetic adaptation, Guinea-pig, Hemoglobin-oxygen affinity, Hypoxia, Hypoxic ventilatory response, Ventilation",

author = "M. Rivera-Ch and F. Le{\'o}n-Velarde and L. Huicho and C. Monge-C",

year = "1994",

month = nov,

doi = "10.1016/0300-9629(94)90209-7",

language = "Ingl{\'e}s",

volume = "109",

pages = "675--680",

journal = "Comparative Biochemistry and Physiology -- Part A: Physiology",

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TY - JOUR

T1 - Ventilatory response to severe acute hypoxia in guinea-pigs and rats with high hemoglobin-oxygen affinity induced by cyanate

AU - Rivera-Ch, M.

AU - León-Velarde, F.

AU - Huicho, L.

AU - Monge-C, C.

PY - 1994/11

Y1 - 1994/11

N2 - Baseline ventilation, hemoglobin concentration (Hb) and P50 were significantly lower in guinea-pigs than in rats. Chronic sodium cyanate (NaOCN) administration did not significantly increase hemoglobin concentration in either guinea-pigs or rats. It decreased the P50 significantly less in guinea-pigs than in rats. The high Hb-O2 affinity experimentally induced did not modify the hypoxic ventilatory response (HVR) of guinea-pigs and rats. At the same level of acute hypoxia, HVR was significantly lower in NaOCN guinea-pigs than in NaOCN rats. Guinea-pigs, genotypically adapted animals to high altitude, displayed relatively minor ventilatory and Hb-O2 affinity changes to NaOCN, and a relatively minor HVR to acute hypoxia. They probably use tissue and biochemical adaptive mechanisms, in addition to their limited extracellular responses to successfully tolerate ambient hypoxia.

AB - Baseline ventilation, hemoglobin concentration (Hb) and P50 were significantly lower in guinea-pigs than in rats. Chronic sodium cyanate (NaOCN) administration did not significantly increase hemoglobin concentration in either guinea-pigs or rats. It decreased the P50 significantly less in guinea-pigs than in rats. The high Hb-O2 affinity experimentally induced did not modify the hypoxic ventilatory response (HVR) of guinea-pigs and rats. At the same level of acute hypoxia, HVR was significantly lower in NaOCN guinea-pigs than in NaOCN rats. Guinea-pigs, genotypically adapted animals to high altitude, displayed relatively minor ventilatory and Hb-O2 affinity changes to NaOCN, and a relatively minor HVR to acute hypoxia. They probably use tissue and biochemical adaptive mechanisms, in addition to their limited extracellular responses to successfully tolerate ambient hypoxia.

KW - Altitude

KW - Cyanate

KW - Genetic adaptation

KW - Guinea-pig

KW - Hemoglobin-oxygen affinity

KW - Hypoxia

KW - Hypoxic ventilatory response

KW - Ventilation

UR - https://www.scopus.com/pages/publications/0027972161

U2 - 10.1016/0300-9629(94)90209-7

DO - 10.1016/0300-9629(94)90209-7

M3 - Artículo

C2 - 8529009

AN - SCOPUS:0027972161

SN - 0300-9629

VL - 109

SP - 675

EP - 680

JO - Comparative Biochemistry and Physiology -- Part A: Physiology

JF - Comparative Biochemistry and Physiology -- Part A: Physiology

IS - 3

ER -

Ventilatory response to severe acute hypoxia in guinea-pigs and rats with high hemoglobin-oxygen affinity induced by cyanate

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Keywords

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