Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana

Ilhem Zebiri; Mohamed Haddad; Laurent Duca; Dominique Harakat; Billy Cabanillas; Lucie Paloque; Amandine Scandolera; Michel Sauvain; Elsa Rengifo; Laurence Voutquenne-Nazabadioko

doi:10.1016/j.phytochem.2016.06.006

Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana

Ilhem Zebiri
, Mohamed Haddad
, Laurent Duca
, Dominique Harakat
, Billy Cabanillas
, Lucie Paloque
, Amandine Scandolera
, Michel Sauvain
, Elsa Rengifo
, Laurence Voutquenne-Nazabadioko

Université
Université de Toulouse
Université de Reims Champagne-Ardenne
Instituto de Investigaciones de la Amazonía Peruana
LCC (Laboratoire de Chimie de Coordination) UPR8241
Université de Toulouse
Givandan ACI

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Twelve oleanane saponins, zebiriosides A-L, were isolated from the roots of Dendrobangia boliviana Rusby, together with two known saponins, talunùmoside I and 3-O-β-D-glucuronopyranosyl serjanic acid. These saponins are glycosides of serjanic or phytolaccinic acid. Their structures were established on two basis: first, their spectral data, mainly HR-TOFESIMS, 1D-NMR (¹H, ¹³C, DEPT) and 2D-NMR (¹H[sbnd]¹H COSY, TOCSY, HSQC, HMBC, and ROESY), and second by comparison with literature data. These compounds were evaluated for their cytotoxic, antileishmanial and hemolytic activities. No antileishmanial or hemolytic activities were revealed, however zebirioside C and zebirioside I showed cytotoxicity against fibroblasts with IC₅₀ of 6.4 and 5.6 μM, respectively.

Original language	English
Pages (from-to)	262-272
Number of pages	11
Journal	Phytochemistry
Volume	130
DOIs	https://doi.org/10.1016/j.phytochem.2016.06.006
State	Published - 1 Oct 2016
Externally published	Yes

Keywords

Cardiopteridaceae
Cytotoxic activity
Dendrobangia boliviana
Triterpenoid saponins

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10.1016/j.phytochem.2016.06.006

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title = "Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana",

abstract = "Twelve oleanane saponins, zebiriosides A-L, were isolated from the roots of Dendrobangia boliviana Rusby, together with two known saponins, talun{\`u}moside I and 3-O-β-D-glucuronopyranosyl serjanic acid. These saponins are glycosides of serjanic or phytolaccinic acid. Their structures were established on two basis: first, their spectral data, mainly HR-TOFESIMS, 1D-NMR (1H, 13C, DEPT) and 2D-NMR (1H[sbnd]1H COSY, TOCSY, HSQC, HMBC, and ROESY), and second by comparison with literature data. These compounds were evaluated for their cytotoxic, antileishmanial and hemolytic activities. No antileishmanial or hemolytic activities were revealed, however zebirioside C and zebirioside I showed cytotoxicity against fibroblasts with IC50 of 6.4 and 5.6 μM, respectively.",

keywords = "Cardiopteridaceae, Cytotoxic activity, Dendrobangia boliviana, Triterpenoid saponins",

author = "Ilhem Zebiri and Mohamed Haddad and Laurent Duca and Dominique Harakat and Billy Cabanillas and Lucie Paloque and Amandine Scandolera and Michel Sauvain and Elsa Rengifo and Laurence Voutquenne-Nazabadioko",

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year = "2016",

month = oct,

day = "1",

doi = "10.1016/j.phytochem.2016.06.006",

language = "Ingl{\'e}s",

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TY - JOUR

T1 - Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana

AU - Zebiri, Ilhem

AU - Haddad, Mohamed

AU - Duca, Laurent

AU - Harakat, Dominique

AU - Cabanillas, Billy

AU - Paloque, Lucie

AU - Scandolera, Amandine

AU - Sauvain, Michel

AU - Rengifo, Elsa

AU - Voutquenne-Nazabadioko, Laurence

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Twelve oleanane saponins, zebiriosides A-L, were isolated from the roots of Dendrobangia boliviana Rusby, together with two known saponins, talunùmoside I and 3-O-β-D-glucuronopyranosyl serjanic acid. These saponins are glycosides of serjanic or phytolaccinic acid. Their structures were established on two basis: first, their spectral data, mainly HR-TOFESIMS, 1D-NMR (1H, 13C, DEPT) and 2D-NMR (1H[sbnd]1H COSY, TOCSY, HSQC, HMBC, and ROESY), and second by comparison with literature data. These compounds were evaluated for their cytotoxic, antileishmanial and hemolytic activities. No antileishmanial or hemolytic activities were revealed, however zebirioside C and zebirioside I showed cytotoxicity against fibroblasts with IC50 of 6.4 and 5.6 μM, respectively.

AB - Twelve oleanane saponins, zebiriosides A-L, were isolated from the roots of Dendrobangia boliviana Rusby, together with two known saponins, talunùmoside I and 3-O-β-D-glucuronopyranosyl serjanic acid. These saponins are glycosides of serjanic or phytolaccinic acid. Their structures were established on two basis: first, their spectral data, mainly HR-TOFESIMS, 1D-NMR (1H, 13C, DEPT) and 2D-NMR (1H[sbnd]1H COSY, TOCSY, HSQC, HMBC, and ROESY), and second by comparison with literature data. These compounds were evaluated for their cytotoxic, antileishmanial and hemolytic activities. No antileishmanial or hemolytic activities were revealed, however zebirioside C and zebirioside I showed cytotoxicity against fibroblasts with IC50 of 6.4 and 5.6 μM, respectively.

KW - Cardiopteridaceae

KW - Cytotoxic activity

KW - Dendrobangia boliviana

KW - Triterpenoid saponins

UR - https://www.scopus.com/pages/publications/84992458937

U2 - 10.1016/j.phytochem.2016.06.006

DO - 10.1016/j.phytochem.2016.06.006

M3 - Artículo

C2 - 27358036

AN - SCOPUS:84992458937

SN - 0031-9422

VL - 130

SP - 262

EP - 272

JO - Phytochemistry

JF - Phytochemistry

ER -

Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana

Abstract

Keywords

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