A novel antiprotozoal aminosteroid from Saracha punctata

C. Moretti; M. Sauvain; C. Lavaud; G. Massiot; J. A. Bravo; V. Muñoz

doi:10.1021/np9800654

A novel antiprotozoal aminosteroid from Saracha punctata

C. Moretti
, M. Sauvain
, C. Lavaud
, G. Massiot
, J. A. Bravo
, V. Muñoz

Unité de Recherche No. 45
Université de Reims Champagne-Ardenne
Universidad Nacional Mayor de San Andrés
Inst. Boliviano de Biol. de Altura

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

66 Citas (Scopus)

Resumen

A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC₅₀ of 25 nM.

Idioma original	Inglés
Páginas (desde-hasta)	1390-1393
Número de páginas	4
Publicación	Journal of Natural Products
Volumen	61
N.º	11
DOI	https://doi.org/10.1021/np9800654
Estado	Publicada - nov. 1998
Publicado de forma externa	Sí

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title = "A novel antiprotozoal aminosteroid from Saracha punctata",

abstract = "A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100\% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50\% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.",

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T1 - A novel antiprotozoal aminosteroid from Saracha punctata

AU - Moretti, C.

AU - Sauvain, M.

AU - Lavaud, C.

AU - Massiot, G.

AU - Bravo, J. A.

AU - Muñoz, V.

PY - 1998/11

Y1 - 1998/11

N2 - A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.

AB - A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.

UR - https://www.scopus.com/pages/publications/0031791054

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DO - 10.1021/np9800654

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EP - 1393

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