Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera

Rosario Rojas; Luz Caviedes; José C. Aponte; Abraham J. Vaisberg; Walter H. Lewis; Gerardo Lamas; César Sarasara; Robert H. Gilman; Gerald B. Hammond

doi:10.1021/np050554l

Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera

Rosario Rojas
, Luz Caviedes
, José C. Aponte
, Abraham J. Vaisberg
, Walter H. Lewis
, Gerardo Lamas
, César Sarasara
, Robert H. Gilman
, Gerald B. Hammond

Facultad de Ciencias e Ingeniería

Universidad Peruana Cayetano Heredia
University of Louisville
Washington University in St. Louis
Museo de Historia Natural, Lima
Confederacion de Nacionalidades Amazónicas Del Perú
Johns Hopkins Bloomberg School of Public Health

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

55 Citas (Scopus)

Resumen

An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).

Idioma original	Inglés
Páginas (desde-hasta)	845-846
Número de páginas	2
Publicación	Journal of Natural Products
Volumen	69
N.º	5
DOI	https://doi.org/10.1021/np050554l
Estado	Publicada - may. 2006

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title = "Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera",

abstract = "An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).",

author = "Rosario Rojas and Luz Caviedes and Aponte, \{Jos{\'e} C.\} and Vaisberg, \{Abraham J.\} and Lewis, \{Walter H.\} and Gerardo Lamas and C{\'e}sar Sarasara and Gilman, \{Robert H.\} and Hammond, \{Gerald B.\}",

year = "2006",

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doi = "10.1021/np050554l",

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AU - Rojas, Rosario

AU - Caviedes, Luz

AU - Aponte, José C.

AU - Vaisberg, Abraham J.

AU - Lewis, Walter H.

AU - Lamas, Gerardo

AU - Sarasara, César

AU - Gilman, Robert H.

AU - Hammond, Gerald B.

PY - 2006/5

Y1 - 2006/5

N2 - An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).

AB - An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).

UR - https://www.scopus.com/pages/publications/33745785031

U2 - 10.1021/np050554l

DO - 10.1021/np050554l

M3 - Artículo

C2 - 16724857

AN - SCOPUS:33745785031

SN - 0163-3864

VL - 69

SP - 845

EP - 846

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera

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